ObjectiveRecurrent spontaneous abortion (RSA) affects 0.5%–2.5% of fertile couples and arises from complex, interacting thrombotic, immune, coagulation, endocrine–metabolic, and demographic factors. However, current early risk stratification in routine…
IntroductionMetastatic recurrence drives dismal survival in esophageal squamous cell carcinoma (ESCC), yet epigenetic mechanisms underlying metastasis remain poorly defined. While DNMT1 and DNMT3A contribute to ESCC pathogenesis, DNMT3B’s role is enigm…
IntroductionPregnancy requires coordinated immunometabolic adaptations that allow maternal immune tolerance while preserving tissue remodeling and host defense. Circulating monocytes contribute critically to these processes, yet how gestation shapes th…
BackgroundAtlantic cod lack functional MHC class II and CD4, raising fundamental questions about how vaccination generates protection in this species. MethodsWe combined single-cell transcriptomic profiling of splenic cells with qRT-PCR across compleme…
IntroductionIt is becoming increasingly evident that SARS-CoV-2 infection is here to stay. Therefore, understanding whether genetic variants may impact the response to the virus or vaccination is crucial. Studies on the genetic determinants of immune …
BackgroundDonor-derived infections (DDIs) have become a significant cause of infection in organ transplant recipients. Elaborating on the species, distribution, and resistance of donor-derived pathogens (DDPs) holds important implications.MethodsA retr…
ObjectiveThe objective was to investigate the association between tonsillectomy and subsequent ankylosing spondylitis (AS) risk, with particular emphasis on racial disparities in disease susceptibility.MethodsA retrospective cohort study was conducted …
ObjectiveTo assess the clinical relevance of diagnosing and classifying isolated IgG deficiency and combined IgG/IgM deficiency separately from CVID.MethodsIn a retrospective cohort of patients with primary hypogammaglobulinemia, we evaluated and compa…
BackgroundRheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and gut microbiota dysbiosis. Gnaphalium hypoleucum DC. total flavonoids (GHTFs) exhibit anti-inflammatory and immunomodulatory properties.Methods and re…
Systemic amyloidosis is a protein folding disorder characterized by the extracellular deposition of protein fibrils in tissues and vital organs, leading to dysfunction and mortality. While there are monoclonal antibody-based therapies that promote cell…
