IntroductionNon-classical neoantigens at the fusion junctions of chimeric RNAs are tumor- specific with a low risk of autoimmunity and therefore represent ideal targets for personalized vaccines. We present a platform to discover immunogenic neoantigen…
IntroductionAortic dissection (AD) is a lethal disease with increasing incidence and limited preventive options, characterized by aortic media degeneration and inflammatory cell infiltration. Dysregulation of lipid metabolism is increasingly recognized…
BackgroundKidney transplantation (KT) is the preferred treatment for patients with end-stage renal disease (ESRD); however, postoperative hyperamylasemia (HA) remains common and has been associated with acute rejection (AR), infection, and impaired gra…
ObjectiveThis study aimed to systematically identify key differentially expressed genes (DEGs) associated with lysine lactylation in osteoporosis and to explore their potential roles in disease pathogenesis from a dual perspective of metabolic and immu…
BackgroundEarly detection of hepatocellular carcinoma (HCC) enhances survival outcomes. Tumor-associated autoantibodies demonstrate early emergence during carcinogenesis, offering potential as non-invasive diagnostic biomarkers. This multicenter study …
IntroductionCochlear implant outcomes can be limited due to immunologically mediated intracochlear foreign body responses, resulting in new bone growth and fibrosis. Minimal consideration has been given to the possible role of immunological memory in m…
BackgroundBreast cancer persists as a principal contributor to global cancer mortality, driven by heterogeneous molecular pathways. Necrosis by sodium overload, a recently characterized form of regulated cell death, remains underexplored in oncogenesis…
Background/IntroductionThe utility of measuring real-time cellular bioenergetics of peripheral blood mononuclear cells (PBMCs) as biomarkers in disease monitoring, such as the bioenergetic health index, is of emerging interest. However, various experim…
ObjectiveTo investigate whether patients with ACPA-negative (ACPA–) and ACPA-positive (ACPA+) rheumatoid arthritis (RA) exhibit distinct immune and metabolic profiles in blood, using integrative proteomic and metabolomic analyses. By uncovering subgrou…
BackgroundIn acute respiratory distress syndrome (ARDS), neutrophils, as the primary effector immune cells, undergo profound transcriptional and phenotypic reprogramming in response to complex inflammatory stimuli, modulating signal transduction and im…
