Background and aimsDefinitions of acute-on-chronic liver failure (ACLF) differ, with a focus on extrahepatic organ failures on the basis of previously compensated or decompensated cirrhosis in EASL-CLIF-ACLF versus hepatic failure in patients without p…
BackgroundVentilator-induced lung injury (VILI) is a major iatrogenic complication of mechanical ventilation, in which dysregulated inflammation, particularly macrophage-driven response, amplifies pulmonary damage. Although bone morphogenetic protein (…
BackgroundPulmonary arterial hypertension (PAH) involves vascular remodeling and altered mechanical signaling. The immune-associated transcriptomic changes accompanying this environment remain incompletely characterized.MethodsWe integrated bulk lung (…
ObjectiveTo develop and internally evaluate a model that uses maternal blood markers obtained before delivery to differentiate neonatal acute respiratory distress syndrome (ARDS) from other causes of respiratory distress in late-preterm and term neonat…
BackgroundElevated levels of interferons (IFN) are a hallmark of Systemic Lupus Erythematosus (SLE) and are linked to disease flares, but the precise mechanisms underlying this remain unclear. We examined the association between IFN-stimulated proteins…
IntroductionFabry disease (FD) is an X-linked lysosomal storage disorder in which chronic inflammation contributes to disease progression beyond substrate accumulation. Although nuclear factor kappa B (NF-κB) signaling has been implicated in FD pathoge…
Background and aimsAscites marks advanced cirrhosis and increases the risk of complications including SBP. Systemic inflammation in liver disease is well characterized, but the immunometabolic properties of the peritoneal compartment remain undefined. …
BackgroundFamilial Mediterranean Fever (FMF) and Celiac Disease (CD) are two distinct inflammatory disorders that arise through different immunological pathways, yet they show a notable tendency to coexist, particularly in Mediterranean populations. Th…
BackgroundTo evaluate podoplanin (PDPN) as a circulating biomarker for early necrotizing enterocolitis (NEC) risk stratification and to determine whether an interpretable machine-learning framework integrating PDPN with prediagnostic clinical and infla…
ObjectiveTo describe pulmonary involvement in childhood-onset primary Sjögren’s syndrome (cSS).MethodsThis retrospective study included 17 children with cSS diagnosed at Jiangxi Provincial Children’s Hospital between August 2021 and August 2025. Patien…
