Photodynamic priming (PDP), a fallout of photodynamic therapy, transiently modulates the tumor microenvironment (TME), enhances therapeutic susceptibility, and promotes immunogenic cell death through the release of damage-associated molecular patterns …
IntroductionPsoriasis is a chronic immune-mediated inflammatory skin disease characterized by spatially organized epithelial, stromal, vascular, and immune interactions. Although aging is associated with inflammatory activation and tissue remodeling in…
IntroductionType I interferon responses are critical determinants of organ-specific antiviral control and metabolic adaptation during Coxsackievirus B3 (CVB3) infection. The interferon-stimulated gene ISG15 integrates antiviral defense with immunometab…
BackgroundLipids serve as both metabolic substrates and signaling mediators that critically regulate immune cell fate, function, tolerance, and intercellular communication. In hepatocellular carcinoma (HCC), it remains unclear how intratumoral linoleic…
BackgroundIschemic brain injury is a major contributor to global mortality and disability. Despite extensive pathological characterization, systematic integration of rodent transcriptomic data remains limited. This study investigates orthologous transc…
BackgroundChronic renal allograft dysfunction (CRAD) continues to limit the long-term survival of transplanted kidneys. Inflammatory cell accumulation during the early phase of CRAD may accelerate fibrotic remodeling and graft dysfunction, although the…
In acute pancreatitis (AP), sudden epigastric pain is accompanied by intense release of inflammatory mediators that rapidly recruit and activate innate immune cells. Pro-inflammatory cytokines (e.g., IL-6, IL-1β, TNF-α) play a key role in amplifying in…
BackgroundHepatocellular carcinoma (HCC) arises in the liver, an organ with active lipid metabolism, and is accompanied by marked myeloid-cell remodeling. Whether lipid-handling macrophage states are enriched in HCC and how they relate to candidate lig…
IntroductionPatients with idiopathic inflammatory myopathies (IIM) are at increased risk of malignancy, particularly around disease onset, but practical tools for risk stratification of cancer-associated myositis (CAM) remain limited. We aimed to chara…
IntroductionGranulocyte colony-stimulating factor (G-CSF) is routinely used to manage chemotherapy-induced neutropenia in patients receiving chemoimmunotherapy for advanced non-small cell lung cancer (NSCLC). However, its potential to promote immunosup…
