IntroductionChikungunya virus (CHIKV) is primarily transmitted to humans through bites of infected Aedes mosquitoes, causing febrile illness as well as acute or chronic arthritis. With increasing reports in previously non-endemic regions, it poses an e…
BackgroundBrucellar arthritis is the most common complication of brucellosis, and its chronic progression is closely associated with immune cell dysfunction. Natural killer (NK) cells play a central role in anti-infective immunity; however, their funct…
IntroductionOsimertinib and cisplatin are widely used as standard treatments for non-small cell lung cancer (NSCLC); however, their effects on tumor microenvironment remodeling remain poorly understood. This study investigated whether TREM2-positive tu…
BackgroundNeuromyelitis optica spectrum disorder (NMOSD) is a neuroimmunological astrocytopathy mediated by anti-aquaporin-4 (AQP4-IgG) antibodies that trigger complement-dependent cytotoxicity and activation of the terminal complement cascade in the c…
The tyrosine kinase ZAP-70 is essential for T-cell activation and development, but the mechanisms regulating its activity remain unclear. Previous studies showed that the Src-family kinase LCK binds phosphorylated tyrosine 319 of ZAP-70 via its SH2 dom…
BackgroundPersistent pediatric lower urinary tract dysfunction (LUTD) may be associated with occult sacral neural impairment, a clinically challenging condition characterized by subtle sacral pathway dysfunction without overt spinal dysraphism.Objectiv…
PurposeTo investigate genetically supported molecular factors associated with uveitis and to evaluate the clinical, transcriptomic, and retinal relevance of intercellular adhesion molecule 5 (ICAM-5) across major immune-mediated non-infectious uveitis …
ObjectivesDespite promising advances in metabolomics for biomarker discovery in systemic lupus erythematosus (SLE), studies examining associations with detailed disease phenotypes, including organ damage and validated outcome measures, remain limited. …
IntroductionCancer genotypes influence transcriptional programs, spatial organization, histopathology, and treatment-response states, yet these molecular and tissue-level features are often analyzed separately in public-data studies. VISTA was develope…
BackgroundANCA-associated vasculitis (AAV) is characterized by pauci-immune small-vessel inflammation driven predominantly by neutrophil activation, in contrast to immune-complex–mediated glomerulopathies in which complement consumption tracks disease …
