IntroductionTuberculosis remains a major global health challenge, with many patients expe- riencing unfavourable treatment outcomes despite standard therapy. Host immune biomarkers, including cytokines, chemokines, and matrix metalloproteinases (MMPs),…
BackgroundNeuromyelitis optica spectrum disorders (NMOSD) are severe autoimmune diseases of the central nervous system characterized by autoantibodies against aquaporin 4 (AQP4-IgG). Despite the availability of several molecular targeted therapies, bio…
BackgroundEvidence linking dietary inflammatory potential with gestational diabetes mellitus (GDM) has been inconsistent. We examined this association in a multicenter cross-sectional study.MethodsWomen attending three tertiary hospitals in Suzhou, Chi…
BackgroundAKNA, an AT-hook transcription factor, plays a critical role in cancer development. However, its prognostic value and biological function in endometrial cancer (EC) remain unclear.MethodsTo systematically investigate AKNA in EC, we integrated…
Tuberculosis (TB) remains the leading cause of death from a single infectious agent worldwide, highlighting the need for improved vaccines beyond the limited protection currently provided by the Bacillus Calmette-Guérin (BCG) vaccine. Here we investiga…
BackgroundPsoriasis is a chronic inflammatory skin disease characterized by dysregulated immune responses and keratinocyte (KC) hyperproliferation. Although therapeutic strategies have advanced considerably, achieving durable long-term remission remain…
BackgroundIn adoptive cell therapy with tumor-infiltrating lymphocytes (TILs), TILs are isolated and expanded ex vivo from an autologous tumor lesion. TIL therapy, comprising preparative lymphodepleting chemotherapy, TIL infusion, and post-infusion sup…
ObjectiveTo characterize the epithelial state associated with GART expression in ulcerative colitis (UC) and determine whether this association reflects a GART-specific program or a broader proliferative and purine-metabolic phenotype.MethodsFour indep…
BackgroundThe devastating pandemic of coronavirus disease 2019 (COVID-19) highlighted the importance of early detection and global collaboration in combating infectious diseases. Namibia is one of the countries that bears a high burden of tuberculosis …
BackgroundABO subtypes are characterized by attenuated antigen expression, rendering them susceptible to serological misclassification and posing substantial risks to transfusion safety. Splice-site variants represent one of the mechanisms underlying A…
