Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome marked by inflammation, immune dysregulation, and myocardial fibrosis. Whether pyroptosis intersects with fibrotic remodeling in HFpEF remains uncertain. Two murine card…
BackgroundMacrophages sense viral double-stranded RNA (dsRNA) via the innate immune receptors TLR3 and MDA5 whose activation drives a robust inflammatory program, often coupled to cell death. TLR3/TRIF-dependent apoptosis has been described in response…
BackgroundCD20×CD3 bispecific antibodies are associated with acute immune-effector toxicities and infections, but drug-specific postmarketing co-reporting and report-level onset patterns remain incompletely characterized in B-cell lymphoma.MethodsWe pe…
BackgroundThe escalating global incidence of multidrug-resistant Neisseria gonorrhoeae necessitates an effective vaccine. While the meningococcal 4CMenB vaccine offers some cross-protection against gonorrhoea, this protection is limited highlighting th…
BackgroundIn systemic inflammatory diseases, thrombotic complications often cannot be fully explained by traditional risk factors, suggesting that the immune system directly affects hemostasis. The complement system, particularly C1q (the recognition m…
BackgroundIntervertebral disc degeneration (IDD) and osteoporosis (OP) frequently coexist, but their shared inflammatory molecular features remain unclear. We investigated whether the two disorders share an immune-extracellular matrix axis and sought c…
ObjectivesEmerging evidence supports the presence of autoantibodies targeting interleukin-1 receptor antagonist (IL-1Ra), a regulator of IL-1 signaling, in adult-onset Still’s disease (AOSD). However, existing data are limited by small cohorts and pote…
IntroductionRecent evidence has demonstrated that both donor- and recipient-derived immune cell subpopulations play a crucial role in various immune responses following allogeneic hematopoietic stem cell transplantation (HSCT). In this retrospective si…
BackgroundAcute exacerbation (AE) is the most lethal event of idiopathic inflammatory myopathy-associated interstitial lung disease (IIM-ILD). This exploratory study compared clinical, radiomics, and combined predictor strategies across five survival-l…
Helicobacter pylori (H. pylori) infection induces persistent colonization and chronic inflammation, yet the mechanisms by which bacterial exposure establishes sustained inflammatory responses remain incompletely understood. We previously demonstrated t…
