Human epidermal growth factor receptor 2 (HER2) is a key oncogenic driver in diverse solid tumors. Although HER2-targeted therapies such as trastuzumab and pertuzumab confer substantial clinical benefits, therapeutic resistance remains a major challeng…
BackgroundObstructive sleep apnea (OSA) is a prevalent disorder characterized by significant metabolic and immune dysregulation. This study aims to uncover exosome-related biomarkers implicated in immune-metabolic disturbances in OSA and explore their …
BackgroundThe lncRNAs associated with protein palmitoylation in breast cancer (BC) remain largely unexplored.MethodsWe retrieved transcriptome, proteome, and mutation data from TCGA-BRCA (BC), identified 592 palmitoylation-related lncRNAs (PRLs), const…
IntroductionSyngeneic mouse tumor models have shown that senescence influences the tumor immune response in multiple ways, including the induction of an immunosuppressive microenvironment or the promotion of immune cell recruitment. Yet, the impact of …
BackgroundDespite the established efficacy of immune checkpoint inhibitors (ICIs) in combination with chemotherapy, with or without anti-angiogenic agents, for extensive-stage small-cell lung cancer (ES-SCLC), a comprehensive comparative assessment of …
ObjectiveBy integrating whole-genome resequencing (WGR) with longitudinal transcriptomic profiling, this study aimed to unravel the genetic–transcriptional regulatory network underlying thyroid immune-related adverse events (irAEs) in non-small cell lu…
Immunotherapy has reshaped the treatment of several cancers, yet patient responses remain highly variable, partly due to differences in immune competence. In soft tissue sarcomas (STS), the immune landscape is poorly characterized, limiting the develop…
IntroductionAmelogenin, used as a periodontal tissue regeneration material, promotes healing after periodontal surgery. A previous study has demonstrated that amelogenin is taken up by macrophages into the nucleus and inhibits major histocompatibility …
IntroductionHemorrhagic disease developed as a consequence of an EEHV infection (EEHV-HD) is the leading cause of death of young Asian elephants in Zoos worldwide and also affects elephants in range countries. Although a cytokine storm has long been su…
BackgroundPatients with Hutchinson-Gilford progeria syndrome (HGPS) typically succumb to cardiovascular diseases in their teens. Although fibroblasts have been implicated in the progression of arteriosclerosis, their roles and mechanisms in progeroid a…
