European Journal of Immunology

FAM83H Regulates Postnatal T Cell Development Through Thymic Stroma Organization. [[{“value”:”Betul Melike Ogan, Veronika Forstlova, Laura Jane Dowling, Michaela Simova, Kristina Vicikova, Vendula Novosadova, Frantisek Spoutil, Sylvie Cervenkova, Michaela Procházková, Jolana Tureckova, Olha Fedosieieva, Juraj Labaj, Petr Nickl, Kamila Krizova, Jan Prochazka, Jana Balounova, Radislav Sedlacek”}]]

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Loss of the casein kinase 1 scaffolding protein FAM83H compromises bone marrow lymphopoiesis, reduces Foxn1 expression in cortical thymic epithelial cells (TEC), disrupts thymic architecture and TEC identity, and ultimately impairs double-negative thymocyte proliferation and T-cell production. ABSTRACT Family of Sequence Similarity 83H (FAM83H/SACK1H) is primarily expressed in epithelial cells, where it interacts with casein … Read more

Shared HLA‐E and Mamu‐E Peptide Repertoires With Subtle Peptide Binding Differences Revealed by Combined nDSF‐ and Fluorescence Polarisation‐Based Methods. [[{“value”:”Max N. Quastel, Sashini A. Ranawana, Bas W. A. Peeters, Andy van Hateren, Andrew J. McMichael, Geraldine M. Gillespie”}]]

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The MHC-E peptide binding methods described here—nano-differential scanning fluorimetry and fluorescence polarisation—demonstrate shared peptide binding repertoires with subtle binding hierarchy differences for the tested HLA-E and Mamu-E allotypes. When combined, these methods illustrate how minor MHC-E-peptide thermal stability changes equate to significant binding strength differences. ABSTRACT The primary function of MHC-E—human leukocyte antigen (HLA)-E in … Read more

The Increased Secretion of Lactate Observed in Obesity and Aging Leads to the Generation of Pathogenic B Cells. [[{“value”:”Maria Romero, Amanda Virtue, Kate Miller, Andrew Gelsomini, Dhananjay Suresh, Sophie LaPointe, Suresh Pallikkuth, Daniela Frasca”}]]

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The increased lactate secretion by B cells from people with obesity and aging is a stimulus for pathogenic autoimmune anti-dsDNA antibodies. The effects of lactate are mediated by phosphorylated signal transducer and activator of transcription 3 (p-STAT3) and inhibited by a neutralizing antibody that blocks the lactate transporter SLC5A12, responsible for lactate uptake and activation … Read more

A Transcriptional Map of Human Tonsil Architecture: Beyond the Sum of (Single Cell) Parts. [[{“value”:”Helena L. Crowell, Laura Llaó‐Cid, Gerard Frigola, Samuel Gunz, Irene Ruano, Patricia Lorden, Max Ruiz, Marta Kulis, José Ignacio Martin‐Subero, Holger Heyn, Elias Campo, Anna Pascual‐Reguant”}]]

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Picture-book compartmentalization makes tonsillar tissue an ideal model to study spatial immunology. Using single-molecule imaging (SMI) of whole-tissue sections, we showcase many an alternative view on tissue composition and architecture that these data and concomitant analyses provide—at the level of single cells, cellular neighborhoods, and anatomical units such as germinal centers and epithelial substructures. ABSTRACT The … Read more

SARS‐CoV‐2 mRNA Vaccination Leads to Transient Humoral and B Cell Bystander Responses in Adults. [[{“value”:”Lisan H. Kuijper, Laura Y. L. Kummer, Laura Fernandez Blanco, Karlijn van der Straten, Mathieu A. F. Claireaux, Amélie V. Bos, Miranda C. Dieker‐Meijer, Tineke Jorritsma, Mariël C. Duurland, Maurice Steenhuis, Juan J. Garcia Vallejo, Koos P. J. van Dam, Eileen W. Stalman, Luuk Wieske, Sander W. Tas, Laura Boekel, Gert‐Jan Wolbink, Theo Rispens, Taco W. Kuijpers, Filip Eftimov, Marit J. van Gils, Anja ten Brinke, S. Marieke van Ham, T2B! immunity against SARS‐CoV‐2 study group”}]]

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SARS-CoV-2 mRNA vaccination triggers bystander activation of B cells, transiently increasing antibody levels after the first vaccination against influenza, RSV, and tetanus. Reactivation of B cell responses also occurred, where (CD11c+) MBC and DN3 are expanded after SARS-CoV-2 mRNA vaccination, independent of antigen exposure. ABSTRACT After antigen encounter, long-lived antibody-secreting cells (ASC) secrete high-affinity circulating … Read more

Synovial Tissue Macrophage Heterogeneity in Rheumatoid Arthritis. [[{“value”:”Megan M. Hanlon, Ursula Fearon, Ellen M. Gravallese”}]]

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Synovial tissue macrophages are essential coordinators of joint homeostasis and inflammatory responses in rheumatoid arthritis. Here, we highlight recent advances that have enabled a deeper characterization of synovial tissue macrophages and their distinct phenotypes and functions in health and disease. ABSTRACT Synovial tissue macrophages are critical orchestrators in the pathogenesis of rheumatoid arthritis, comprising a … Read more

Cover Story: Eur. J. Immunol. 1’26.

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Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more

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