European Journal of Immunology

CD4+ T‐Cell‐Intrinsic IL‐6 Is Critical for Th17 Differentiation and Dampened Responsiveness to CD8+ T Cell‐Mediated Suppression. [[{“value”:”Chakrapani Vemulawada, Kshitija Kale, Michael P. Crawford, Nitin J. Karandikar”}]]

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1. Normal state: T-cell-endogenous IL-6 stabilizes IL6R and promotes STAT3 activation, functional Th17 differentiation with resistance to immune suppression. 2. Il6-KO: Loss of T-cell endogenous IL-6 destabilizes IL6R expression, leading to suboptimal Th17 and greater susceptibility to suppression, despite availability of exogenous IL-6. 3. IL-21 bypasses the requirement for endogenous IL-6 by restoring STAT3 signaling … Read more

Latent, Lytic, and Linked to Multiple Sclerosis—How EBV Drives Autoimmunity. [[{“value”:”Fabienne Läderach, Elena Bremer, Christian Münz”}]]

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EBV latent and lytic genes uniquely contribute to Multiple Sclerosis development by various immunopathogenic mechanisms in susceptible hosts. Briefly, EBV infection shapes the B-cell repertoire and promotes the oligoclonal expansion and subsequent CNS infiltration of T-bet+CXCR3+ B cells, resulting in a cascade of immune dysregulation, CNS inflammation, and autoreactive T cell stimulation. Created in BioRender. … Read more

Discovery of Lomitapide as a Novel Mast Cell Regulatory Agent Through Chemical Library Screening. [[{“value”:”Shiori Mamorita, Atsushi Furukawa, Yuka Nagata, Ryo Suzuki”}]]

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Chemical library screening identified lomitapide as a novel mast cell (MC) regulatory agent. Lomitapide selectively inhibits IgE/Ag- or phorbol 12-myristate 13-acetate (PMA)/ionomycin-mediated MC degranulation by altering plasma membrane dynamics, including endocytosis and membrane fusion. ABSTRACT Allergic diseases are a global health concern, and new molecular insights and therapeutic agents are necessary to support future research … Read more

IL‐21 Selectively Augments Cytotoxic Potential of Antigen‐Activated MAIT Cells. [[{“value”:”Laura E. Wedlock, Rajesh Lamichhane, Meg C. Webley, Selena C. L. Gilmer, Andrea J. Vernall, James E. Ussher”}]]

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Using an in vitro PBMC assay, we found that the addition of exogenous IL-21 enhances the cytotoxic potential of MAIT cells activated by 5-OP-RU. IL-21 induces STAT phosphorylation and provides co-stimulation to TCR-activated MAIT cells, selectively augmenting granzyme B and perforin expression without enhancing interferon-gamma or TNF production at 6 h. ABSTRACT Mucosal-associated invariant T (MAIT) … Read more

Charting Bird Tregs. [[{“value”:”Lingling Wu, Jingxia Wu, Guoliang Cui”}]]

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FoxP3, a lineage-defining transcription factor, defines mammalian Tregs together with antibodies against CD25, GITR, and CTLA-4. No valid chicken anti-FoxP3 or surface CTLA-4 antibodies are available to date. Given current experimental tools, the study proposes CD4+CD25+GITR+ as a practical panel for phenotypic characterization and sorting of viable chicken Tregs. ABSTRACT Regulatory T cells (Tregs) are … Read more

Distinguishing Features of ILC2s During Type 2 Immune Responses. [[{“value”:”Manuel O. Jakob, Patrycja M. Forster, Christoph S. N. Klose”}]]

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Group 2 innate lymphoid cells (ILC2s) are tissue-resident cells regulated by diverse signals often emanating from surrounding nonhematopoietic cells at barrier surfaces. Their effector cytokines determine tissue homeostasis at steady state and during type 2 immunity in allergies or worm infections. Redundant and unique functions of ILC2s and T cells are assessed in this context. … Read more

Multi‐Omics Analysis Reveals Sex‐Specific Signatures for BCG Vaccine Efficacy. [[{“value”:”Qiuyao Zhan, Liang Zhou, Jianbo Fu, Xun Jiang, Xuan Liu, Wenchao Li, Simone J.C.F.M. Moorlag, Valerie A.C.M. Koeken, L. Charlotte J. de Bree, Vera P. Mourits, Leo A.B. Joosten, Yang Li, Mihai G. Netea, Cheng‐Jian Xu”}]]

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Sex-specific pre-vaccination immune landscapes associated with effective BCG vaccine responses. Male high responders exhibit a monocyte-enriched, pro-inflammatory innate immune profile, whereas female high responders display immune signatures associated with enhanced adaptive immune responses. ABSTRACT Vaccines are a cornerstone of global public health, but their efficacy can vary significantly among individuals. Bacille Calmette-Guérin (BCG) vaccine against … Read more

Meningococcal Serogroup Y Meningitis Reveals Inborn Factor B Deficiency. [[{“value”:”Camille Bougeard, Eléonore Eskander, Paula Vieira Martins, Joan Bitan, Julia Roquigny, Christèle Kyheng, Tamazoust Guiddir, Véronique Frémeaux‐Bacchi, Cécile Gonnin, Carine ElSissy”}]]

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We report a novel case of complete complement Factor B deficiency revealed by invasive meningococcal disease. Using combined functional and genetic analyses, we demonstrate that loss of Factor B abolishes alternative pathway activity despite detectable protein levels. These findings provide a mechanistic framework relevant to complement diagnostics and to the clinical use of Factor B … Read more

Cytomegalovirus‐Based Viral Vectors Elicit Robust Systemic and Tissue‐Resident Immune Response Against SARS‐CoV‐2 Antigens. [[{“value”:”Maja Cokarić Brdovčak, Jelena Materljan Franki, Marko Šustić, Karmela Miklić, Magdalena Medved, Lydia Gaćina, Tina Ružić, Stipan Jonjić, Ilija Brizić, Astrid Krmpotić”}]]

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We developed murine CMV-based viral vectors expressing SARS-CoV-2 spike antigen and compared immune response following intraperitoneal and intranasal delivery. Route of vaccine administration shaped antibody and CD8+ T cell response magnitude, kinetics, and tissue residency, highlighting the potential of CMV vectors for induction of protective lung immunity. Created in https://BioRender.com. ABSTRACT Current COVID-19 vaccines face … Read more

Isolation of Pure Stable Human Treg Cells Based on Expression of GPA33. [[{“value”:”Florencia Morgana, Edith Slot, Derk Amsen”}]]

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GPA33 identifies stable human regulatory T cells suitable for therapeutic use. GPA33+ Treg subsets expand efficiently, maintain high FOXP3+Helios+ expression, and lack production of IL-2, IFNγ, and IL-17A. GPA33, alone or combined with TIGIT, also enables robust post-expansion isolation of pure, stable Treg cells for adoptive cell therapy. ABSTRACT Adoptive cell therapy (ACT) with regulatory … Read more

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