European Journal of Immunology

Minor Splicing Factor RNPC3 Is Essential for the Germinal Center B Cell Response. [[{“value”:”Jing Wang, Gui‐Xin Ruan, Yuxing Li, Xiong Xiao, Zhijian Zhu, Wenjing Chen, Hengjun Huang, Rui Zhang, Ruisi Wang, Meiyuan Chen, Ling Guo, Yan Li, Shengli Xu, Xijun Ou”}]]

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RNPC3, as a unique minor spliceosome component, plays a critical role in T cell-dependent immune response. By facilitating minor intron splicing, RNPC3 promotes the proliferation of activated B cells and prevents their apoptosis, thereby supporting the formation of early germinal center B cells. ABSTRACT Germinal center (GC) response ensures the generation of diverse and high-affinity … Read more

Epigenetic Regulation of CD8+ Effector T Cell Differentiation by PDCD5. [[{“value”:”Lixue Jin, Xin Zhang, Jingyi Wang, Yujia Wang, Ke Wang, Zhuolin Wang, Pingzhang Wang, Xiuyuan Sun, Jie Hao, Rong Jin, Dan Lu, Qing Ge”}]]

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In CD8+ T cells, PDCD5 is an activation-induced molecule that interacts with PRDM9, thereby promoting its nuclear translocation and facilitating the H3K4me3 modification of genes associated with effector differentiation. ABSTRACT Epigenetic modification plays a crucial role in establishing the transcriptional program that governs the differentiation of CD8+ effector T cells. However, the mechanisms by which … Read more

ICAM‐1 Is Overexpressed by Cancers and Negatively Impacts Antibody‐Based Therapies Including Antibody–Drug Conjugates. [[{“value”:”J. Bradford Kline, Luigi Grasso, Nicholas C. Nicolaides”}]]

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Tumor-produced ICAM-1 protein binds to IgG1 antibodies and suppresses their antibody-dependent cellular (ADCC) and complement-dependent (CDC) cytotoxicity against antigen-positive cells via reduced engagement with CD16a receptors on immune effector cells and C1q complement protein. This interaction also reduces antibody internalization that negatively affects antibody–drug conjugate cytotoxicity. ABSTRACT Humoral immunity utilizes antibodies and immune effector cells to … Read more

JAK Inhibitors and B Cell Function: A Comparative Study of Their Impact on Plasma Cell Differentiation, Cytokine Production, and Naïve B Cell Activation. [[{“value”:”Wenqi Huang, Charlotte de Vries, Ravi Kumar Sharma, Kittikorn Wangriatisak, Katerina Chatzidionysiou, Vivianne Malmström, Caroline Grönwall”}]]

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JAK inhibitors (baricitinib, tofacitinib, upadacitinib), except for filgotinib, significantly reduce plasmablast differentiation but only partly inhibit activation of naïve B cells and exert a more modest effect on TNF and IL-8 production. Unlike other JAK inhibitors, filgotinib selectively inhibits STAT5 phosphorylation without affecting STAT3 phosphorylation in response to IL-21. ABSTRACT B cells play a crucial … Read more

A Mouse Model for Generation of Gut Lamina Propria Plasma Cells Specific for a Deamidated Gluten Peptide. [[{“value”:”Runa I. Løberg, Alisa E. Dewan, Liv Kleppa, M. Fleur du Pré, Ludvig M. Sollid”}]]

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The 1E03 immunoglobulin knock-in mouse produces B cells reactive to deamidated gluten peptides (DGP). The transfer of DGP-specific B cells and immunization with a DGP-cholera toxin conjugate led to the formation of DGP-reactive small-intestinal lamina propria plasma cells and serum antibodies. This model enables studies of plasma cells associated with celiac disease. ABSTRACT Celiac disease … Read more

Monogenic Common Variable Immunodeficiency (Mo‐CVID) Score for Optimizing the Genetic Diagnosis in Pediatric CVID Cohort. [[{“value”:”Federica Barbati, Lorenzo Lodi, Silvia Boscia, Martina Cortimiglia, Elisa Calistri, Francesca Quaranta, Laura Maggi, Alessio Mazzoni, Boaz Palterer, Francesco Annunziato, Chiara Azzari, Silvia Ricci”}]]

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A mutation was identified in 47% of the CVID-enrolled patients and, in the majority, it was not related to CVID according to the IUIS classification, leading to a diagnostic metamorphosis of this pathological entity. The Mo-CVID Score could help clinicians prioritize genetic analysis in pediatric CVID patients. The image was created with BioRender.com. ABSTRACT Common … Read more

Duplicated TLRs Possess Sub‐ and Neo‐Functionalization to Broaden Their Ligand Recognition in Crucian Carp (Carassius auratus). [[{“value”:”Yihui Fan, Miaomiao Wu, Caijiao Dai, Lijuan Li, Junfa Yuan”}]]

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In crucian carp (Carassius auratus), TLR3 and TLR5 can cross-sense the dsRNA analogue poly (I: C) and bacterial flagella, activating the associated immune response. It is an evolutionary strategy for fish to tackle various pathogens in aquatic environment. ABSTRACT Toll-like receptors (TLRs) play a crucial role in the immune response to pathogen invasion. The TLR … Read more

Tumor Glycosylation: A Main Player in the Modulation of Immune Responses. Ernesto Rodriguez

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Cancer cells present aberrant glycosylation patterns that contribute to the evasion of antitumor immunity by triggering lectin receptors. Therefore, tumor glycosylation represents an interesting target for novel immunotherapy strategies. This review discusses the different mechanisms by which tumor-derived glycans induce tolerogenic programs in immune cells and their clinical significance. ABSTRACT Tumor immune escape refers to the … Read more

Differences in Phage Recognition and Immunogenicity Contribute to Divergent Human Immune Responses to Escherichia coli and Klebsiella pneumoniae Phages. [[{“value”:”Huu Thanh Le, Carola Venturini, Alicia Fajardo Lubian, Bethany Bowring, Jonathan Iredell, Jacob George, Golo Ahlenstiel, Scott A. Read”}]]

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Clinical grade JIPh_Ec70 phages but not JIPh_Kp127 phages elicit a potent inflammatory response in peripheral immune cells. JIPh_Ec70 phagocytic engulfment is facilitated by complement opsonization, resulting in STING activation by phage DNA, driving an inflammatory signaling cascade. Understanding phage immunogenicity will be a key factor in developing effective phage therapies in the coming years. ABSTRACT … Read more

Interferons and Cytokines Induce Transcriptional Activation of the Long‐Interspersed Element‐1 in Myeloid Cells from Autoimmune Patients. [[{“value”:”Ethan Le, Fatemeh Moadab, Xiaoxing Wang, Rayan Najjar, Sadie J. Van den Bogaerde, Alison Bays, John LaCava, Tomas Mustelin”}]]

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Patients with systemic lupus erythematosus (SLE) frequently have autoantibodies against the ORF1p protein encoded by the retrotransposon “long interspersed element-1” (LINE-1 or L1). Here, we report that type I interferon and other cytokines or toll-like receptor agonists induce a rapid increase in L1 transcripts and ORF1p in myeloid cells. ABSTRACT Approximately 17% of our genome … Read more

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