European Journal of Immunology

Enhanced MHC Class‐II Expression in Fibroblastic Reticular Cells Associates with Maturation. [[{“value”:”Janna E. G. Roet, Catarina Gago da Graça, Michael de Kok, Daphne Panocha, Tanja Konijn, Henk P. Roest, Luc J. W. van der Laan, Lisa G. M. van Baarsen, Charlotte M. de Winde, Reina E. Mebius”}]]

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Fibroblastic reticular cells (FRCs) in lymph nodes contribute to peripheral tolerance via MHC-class-II-mediated antigen presentation. Using scRNAseq and protein analysis, we identify BST1+CD200+ FRCs, including the mature T cell-zone FRCs, as key MHC-class-II expressing subsets in mice and humans, highlighting their potential role in immune regulation. ABSTRACT Autoimmunity can be initiated by autoreactive T cells … Read more

Not Just Passing Through: Bone Marrow as a Home for Diverse Resident T Cells. [[{“value”:”Kyra D. Zens, Klaas P. J. M. van Gisbergen”}]]

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CD8+CD69− memory T cells (Schneider Revueltas et al.) were identified to reside in bone marrow besides canonical CD8+CD69+ tissue-resident memory T cells (TRM). In addition, CD4+CD69+ Tr1-like cells (Pulvirenti et al.) were preferentially found in bone marrow. Together, these findings illustrate diversity in the T cell subsets that reside long-term within the bone marrow. ABSTRACT Recent studies … Read more

Differential Regulation of TCR‐Induced ZFP36 and ZFP36L1 Expression by Cyclosporin A in CD8+ T Cells. [[{“value”:”Marian Jones Evans, Twm J. Mitchell, Magdalena Zaucha, Georg Petkau, Martin Turner”}]]

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Proposed mechanism underlying the repression of ZFP36 and induction of ZFP36L1 by calcineurin. ELK-1 is activated by stimuli and promotes the transcription of Zfp36. Calcineurin dephosphorylates active ELK-1 to inhibit its positive effect on Zfp36 transcription, while promoting NFAT-mediated Zfp36l1 transcription. ABSTRACT CD8+ T cells target infected or malignant cells via the production of pro-inflammatory … Read more

The Phenotypical and Functional Effect of PGE2 on Human Macrophages. [[{“value”:”Maren Pfirrmann, Johanna Bödder, Rowan Wuestenenk, Jesse Tennebroek, Kirti K. lyer, Dennis Poel, Daniele V.F. Tauriello, Martijn Verdoes, I. Jolanda M. de Vries”}]]

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Prostaglandin E2 (PGE2) signaling through E-prostanoid receptors (EP) 2 and 4 induces a distinct human macrophage phenotype and affects their functions. Targeting the PGE2-EP2/4 axis in macrophages with soluble or nanoparticle-encapsulated EP2/4 antagonists counteracts the PGE2-induced effect in a 2D and 3D tumor microenvironment using patient-derived tumor organoids. ABSTRACT Prostaglandin E2 (PGE2) is one important … Read more

Multifaceted Role of ILCs in Metabolic Adaptations: From Adult to Neonate. [[{“value”:”Fabian Guendel, Emelyne Lécuyer”}]]

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Innate lymphoid cells (ILCs) have emerged as critical regulators of immune defense, tissue repair, and metabolic homeostasis. By integrating environmental cues, they orchestrate tissue-specific metabolic adaptation. This review discusses ILC functions in adult energy regulation and proposes that neonatal ILCs play essential roles in postnatal metabolic and tissue maturation. ABSTRACT In the almost two decades … Read more

Cover Story: Eur. J. Immunol. 11’25.

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Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more

Epigenetically Controlled ZEB2 Expression Promotes the Cytotoxic Potential of CMV‐Specific CD8+ T Cells. [[{“value”:”Varun Sasidharan Nair, Zheng Yu, Hosein Ahmadi, Agnes Bonifacius, Beate Pietzsch, Dirk H. Busch, Luka Cicin‐Sain, Fabian Müller, Kilian Schober, Britta Eiz‐Vesper, Stefan Floess, Jochen Huehn”}]]

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Differentially methylated regions (DMRs) within the ZEB2 locus progressively demethylate during CD4+ and CD8+ T cell differentiation into cytotoxic CD4+ and CD8+ TEMRA subsets, respectively. This epigenetic remodeling tightly correlates with elevated ZEB2 expression, and ZEB2 knockout (KO) impairs the effector and cytotoxic function of CD4+ and CD8+ T cells. ABSTRACT Zinc finger E-box binding … Read more

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