European Journal of Immunology

Perturbances in Both Circulating B and CD4+ T Cells Discriminate Multiple Sclerosis from Other Central Nervous System Autoimmune Diseases. [[{“value”:”Laurens Bogers, Jasper Rip, Suzanne C. Franken, Kirsten L. Kuiper, Ana M. Marques, Annet F. Wierenga‐Wolf, Marie‐José Melief, Cato E. A. Corsten, Romy A. M. Klein Kranenbarg, Janet de Beukelaar, Ide Smets, Beatrijs H. Wokke, Maarten J. Titulaer, Joost Smolders, Marvin M. van Luijn”}]]

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Using spectral flow cytometry, we analyzed circulating lymphocyte subsets in treatment-naive individuals with multiple sclerosis (MS) and other central nervous system autoimmune diseases (CNS AIDs). Elevated B-cell and CD4+ T-cell frequencies were a disease-specific feature of MS, while reduced T-bet+ and CXCR3+ B-cell levels were associated with progressive disease.

Cellular Cosmetics: How Innate Lymphoid Cells Can Recontour the Tumour Microenvironment. [[{“value”:”Nabina Pun, David R. Withers”}]]

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Innate lymphoid cells (ILCs) orchestrate tissue homeostasis and inflammation. Here, we review current understanding of how different subsets of ILCs can contribute to both pro- and anti-tumour immunity depending on the local context. ABSTRACT The innate lymphoid cell (ILC) family includes natural killer (NK) cells, recognised for over 50 years, as well as several more … Read more

Bacterial Vaginosis‐Associated Prevotella timonensis Enhances Dendritic Cell–T Cell Clustering and Subsequent T Cell Proliferation. [[{“value”:”Marleen Y. van Smoorenburg, Julia L. Nerwinska, John L. van Hamme, Ester B. M. Remmerswaal, Celia Segui‐Perez, Karin Strijbis, Teunis B. H. Geijtenbeek”}]]

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Prevotella timonensis, a bacterium present during vaginal dysbiosis, increases cell–cell clustering between primary DCs and CD4 T cells and subsequently enhances CD4 T cell proliferation. These results provide insight into how microbiota directly affect the immunological function of DCs, thereby modulating inflammation. Created in BioRender. Geijtenbeek, T. (2025) https://BioRender.com/t02mfss. ABSTRACT Dysbiosis of the vaginal microbiome … Read more

STING and Nonnecroptotic MLKL‐Mediated Mechanisms Improve Dendritic Cell Maturation and Killing of Cancer Cells. [[{“value”:”Trine S. Jensen, Marlene F. Laursen, Lea Schort, Agnieszka J. Banasik, Ralf Agger, Martin R. Jakobsen, Emil Kofod‐Olsen”}]]

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In this study, we show that caspase-8 inhibition induce maturation in DCs through a synergistic crosstalk between the STING signaling pathway and RIPK1-RIPK3-MLKL pathway, without induction of cell death in the DCs. The mature DCs secrete TNF-α that induces cancer cell death in DC/cancer cell co-cultures upon concomitant caspase-8 inhibition. ABSTRACT Activation of the cGAS-STING … Read more

Natural Killer Cells Are Dispensable for Virus Control in Rag2−/− Mice During Primary RSV Infection. [[{“value”:”Joy Nakawesi, Tammie Sow Tao Min, Cecilia Johansson”}]]

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Rag2−/− mice are unable to clear respiratory syncytial virus (RSV) infection, despite an earlier recruitment of natural killer (NK) cells to the lungs compared with wild-type controls. Furthermore, depletion of NK cells does not affect viral load, indicating that alternative innate anti-viral mechanisms may compensate in the absence of adaptive immunity. ABSTRACT Respiratory syncytial virus … Read more

Cover Story: Eur. J. Immunol. 9’25.

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Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more

Baseline Single‐Cell Differences in Polyfunctionality Between Systemic Autoinflammatory Diseases Patients and Healthy Controls. [[{“value”:”Aline Linder, Farah Diab, Loïc de Pontual, Irina Giurgea, Klaus Eyer”}]]

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Dysregulated cytokine secretion and signaling underlie systemic autoinflammatory diseases (SAIDs). Here, we characterized immune dysregulation in SAID patients by profiling cytokine secretion at the single-cell level, establishing measurements for secretion dynamics and cellular polyfunctionality, compared with healthy controls, revealing natural variability within immune responses between donors.

Sustained Lung Inflammation Post‐SARS‐CoV‐2 Infection in Mice Is Associated with Increased Pulmonary T Cells. [[{“value”:”Sophie Y. Guan, Patricia P. Ogger, Ana Farias, Minerva Garcia Martín, Joy Nakawesi, Olivia Bedard, Candice Baker, Nadia Rosenthal, Cecilia Johansson”}]]

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Low-dose SARS-CoV-2 infection in 129 × C57BL/6-K18-hACE2 mice induces sustained lung inflammation. Despite complete viral clearance and full recovery of body weight by day 8 post-infection, both CD4+ and CD8+ T cells remained detectable in the lungs up to day 28 post infection, indicating ongoing immune activity. ABSTRACT Many SARS-CoV-2 patients experience chronic pulmonary symptoms … Read more

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