European Journal of Immunology

MicroRNA‐146a deficiency enhances host protection against murine cytomegalovirus. [[{“value”:”Pamela Wong, Jeffrey W. Leong, Hyogon Sohn, Lily Chang, Catherine R. Keppel, Carly C. Neal, Celia C. Cubitt, Tony Yao, Molly P. Keppel, Jennifer Tran, Allison Burdi, Kimberly Hwang, Leslie A. Fogel, Timothy Schappe, Lynne Marsala, Melissa M. Berrien‐Elliott, Julia A. Wagner, Stephanie E. Schneider, Ryan P. Sullivan, Jeanette T. Pingel, Megan A. Cooper, Anthony R. French, Todd A. Fehniger”}]]

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MiR-146a−/− mice are protected from lethal MCMV infection. This protection is dependent on miR-146a expression in the hematopoietic compartment and NK cells. miR-146a−/− mice have increased liver mature NK cells, STAT-1 phosphorylation, and Ly49H+ NK cell and T-cell expansion, which can contribute to protecting the host from lethal MCMV. Abstract Natural killer (NK) cells are … Read more

Probing TCR Specificity Using Artificial In Vivo Diversification of CDR3 Regions. [[{“value”:”Orlando B. Giorgetti, Annette Haas‐Assenbaum, Thomas Boehm”}]]

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Diversification of transgenic TCRs by CRISPR/Cas9-mediated mutagenesis of Tcra and Tcrb chain genes in vivo converts monoclonal repertoires of known specificity into an oligoclonal pool of TCRs of altered antigen reactivities. This generally applicable approach helps to identify crucial amino acid residues in the CDR3 regions required for antigen recognition. ABSTRACT The T-cell receptor sequences … Read more

Function and Spatial Organization of Tumor‐Invasive Human γδ T Cells—What Do We Know?. [[{“value”:”Kilian Wistuba‐Hamprecht, Hans‐Heinrich Oberg, Daniela Wesch”}]]

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This review provides deeper insights into the localization of intra-tumoral γδ T lymphocytes in solid tumors. Additionally, a pro- or anti-tumoral influence of the tumor microenvironment and expression of checkpoint inhibitory molecules on γδ T cell functionality is described. To overcome the suppression of tumor-infiltrating γδ T cells, future immunotherapy approaches are summarized. ABSTRACT Human … Read more

IL1R2 Acts as a Negative Regulator of Monocyte Recruitment During Inflammation. [[{“value”:”Adeline Cros, Elodie Segura”}]]

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Il1r2 deficiency in monocytes dysregulates their trafficking to inflamed tissues through increased production of the monocyte chemoattractant CCL2. ABSTRACT IL1-β plays a central role in inflammation but its biological action needs to be tightly controlled. Such negative regulation can be exerted by the decoy receptor IL1R2. However, IL1R2 biology in immune cells remains poorly characterized, … Read more

Distinct Requirements for CD4+ T Cell Help for Immune Responses Induced by mRNA and Adenovirus‐Vector SARS‐CoV‐2 Vaccines. [[{“value”:”Lyn Yong, Claire Hutchings, Eleanor Barnes, Paul Klenerman, Nicholas M. Provine”}]]

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The role of CD4+ T cells in promoting cellular and humoral immunity induced by novel mRNA–LNP and adenovirus vector vaccine technologies is incompletely understood. Surprisingly, we identified a discordant need for CD4+ T cell help based on both vaccine platform and arm of adaptive immunity examined. These data provide further evidence of the unique biology … Read more

Differential Characteristics on TCR Embedding Landscape Among Immune Checkpoint Blockade Responders Versus Non‐Responders Against Non‐Small Cell Lung Carcinoma. [[{“value”:”Peiling Tsou, Chang‐Jiun Wu”}]]

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For each patient in the NSCLC cohort, TCR sequences were converted into numerical vectors using the TCR2Vec model and projected onto a 2D landscape. The aggregated fractions of anti-LAA TEGs per patient were calculated. ICB responders had over-represented anti-LAA TEGs compared to non-responders.

Memory Phenotype Tfh Cells Develop Without Overt Infection and Support Germinal Center Formation and B Cell Responses to Viral Infection. [[{“value”:”Alistair L. J. Symonds, Zabreen Busharat, Mengmeng Du, Tizong Miao, Suling Li, Xiujuan Hou, Ping Wang”}]]

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In the steady state, naïve CD4 T cells can develop into memory phenotype (MP) cells. We discovered that MP T cells include a subpopulation of Tfh cells. MP Tfh cells share key markers with pathogen-induced memory Tfh cells and can support germinal center formation and antibody responses to infection. ABSTRACT Pathogen-induced memory Tfh cells are … Read more

Metabolic Reprogramming of Fibroblastic Reticular Cells in Immunity and Tolerance. [[{“value”:”Dejun Kong, Marina WillsonShirkey, Wenji Piao, Long Wu, Shunqun Luo, Allision Kensiski, Jing Zhao, Young Lee, Reza Abdi, Hong Zheng, Jonathan S. Bromberg”}]]

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This review addresses how fibroblastic reticular cells (FRCs) undergo metabolic reprogramming in response to infections, autoimmune diseases, and cancer, adjusting their glycolysis, oxidative phosphorylation, and fatty acid metabolism to modulate immune functions. These metabolic shifts in FRCs highlight potential therapeutic strategies to improve immune regulation across various disease contexts. ABSTRACT Fibroblastic reticular cells (FRCs) are … Read more

Cytokine Autoantibodies Alter Gene Expression Profiles of Healthy Donors. [[{“value”:”Jakob Hjorth von Stemann, Florian Dubois, Violaine Saint‐André, Vincent Bondet, Celine Posseme, Bruno Charbit, Lluis Quintana‐Murci, Morten Bagge Hansen, Sisse Rye Ostrowski, Darragh Duffy, Milieu Intérieur Consortium”}]]

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Working on the 1000-donor Milieu Interieur cohort with ex vivo whole blood stimulation, we demonstrate that naturally occurring cytokine autoantibodies (c-aAb) in healthy donors can neutralize cytokine availability and regulate proinflammatory gene expression. ABSTRACT Autoantibodies against cytokines (c-aAb) have been implicated in the pathophysiology of autoimmune diseases, and a variety of infections. In addition, several … Read more

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