European Journal of Immunology

A Mouse Model for Generation of Gut Lamina Propria Plasma Cells Specific for a Deamidated Gluten Peptide. [[{“value”:”Runa I. Løberg, Alisa E. Dewan, Liv Kleppa, M. Fleur du Pré, Ludvig M. Sollid”}]]

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The 1E03 immunoglobulin knock-in mouse produces B cells reactive to deamidated gluten peptides (DGP). The transfer of DGP-specific B cells and immunization with a DGP-cholera toxin conjugate led to the formation of DGP-reactive small-intestinal lamina propria plasma cells and serum antibodies. This model enables studies of plasma cells associated with celiac disease. ABSTRACT Celiac disease … Read more

Monogenic Common Variable Immunodeficiency (Mo‐CVID) Score for Optimizing the Genetic Diagnosis in Pediatric CVID Cohort. [[{“value”:”Federica Barbati, Lorenzo Lodi, Silvia Boscia, Martina Cortimiglia, Elisa Calistri, Francesca Quaranta, Laura Maggi, Alessio Mazzoni, Boaz Palterer, Francesco Annunziato, Chiara Azzari, Silvia Ricci”}]]

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A mutation was identified in 47% of the CVID-enrolled patients and, in the majority, it was not related to CVID according to the IUIS classification, leading to a diagnostic metamorphosis of this pathological entity. The Mo-CVID Score could help clinicians prioritize genetic analysis in pediatric CVID patients. The image was created with BioRender.com. ABSTRACT Common … Read more

Duplicated TLRs Possess Sub‐ and Neo‐Functionalization to Broaden Their Ligand Recognition in Crucian Carp (Carassius auratus). [[{“value”:”Yihui Fan, Miaomiao Wu, Caijiao Dai, Lijuan Li, Junfa Yuan”}]]

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In crucian carp (Carassius auratus), TLR3 and TLR5 can cross-sense the dsRNA analogue poly (I: C) and bacterial flagella, activating the associated immune response. It is an evolutionary strategy for fish to tackle various pathogens in aquatic environment. ABSTRACT Toll-like receptors (TLRs) play a crucial role in the immune response to pathogen invasion. The TLR … Read more

Tumor Glycosylation: A Main Player in the Modulation of Immune Responses. Ernesto Rodriguez

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Cancer cells present aberrant glycosylation patterns that contribute to the evasion of antitumor immunity by triggering lectin receptors. Therefore, tumor glycosylation represents an interesting target for novel immunotherapy strategies. This review discusses the different mechanisms by which tumor-derived glycans induce tolerogenic programs in immune cells and their clinical significance. ABSTRACT Tumor immune escape refers to the … Read more

Differences in Phage Recognition and Immunogenicity Contribute to Divergent Human Immune Responses to Escherichia coli and Klebsiella pneumoniae Phages. [[{“value”:”Huu Thanh Le, Carola Venturini, Alicia Fajardo Lubian, Bethany Bowring, Jonathan Iredell, Jacob George, Golo Ahlenstiel, Scott A. Read”}]]

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Clinical grade JIPh_Ec70 phages but not JIPh_Kp127 phages elicit a potent inflammatory response in peripheral immune cells. JIPh_Ec70 phagocytic engulfment is facilitated by complement opsonization, resulting in STING activation by phage DNA, driving an inflammatory signaling cascade. Understanding phage immunogenicity will be a key factor in developing effective phage therapies in the coming years. ABSTRACT … Read more

Interferons and Cytokines Induce Transcriptional Activation of the Long‐Interspersed Element‐1 in Myeloid Cells from Autoimmune Patients. [[{“value”:”Ethan Le, Fatemeh Moadab, Xiaoxing Wang, Rayan Najjar, Sadie J. Van den Bogaerde, Alison Bays, John LaCava, Tomas Mustelin”}]]

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Patients with systemic lupus erythematosus (SLE) frequently have autoantibodies against the ORF1p protein encoded by the retrotransposon “long interspersed element-1” (LINE-1 or L1). Here, we report that type I interferon and other cytokines or toll-like receptor agonists induce a rapid increase in L1 transcripts and ORF1p in myeloid cells. ABSTRACT Approximately 17% of our genome … Read more

Age and Latent Cytomegalovirus Infection Do Not Affect the Magnitude of De Novo SARS‐CoV‐2‐Specific CD8+ T Cell Responses. [[{“value”:”Jet van den Dijssel, Veronique A. L. Konijn, Mariël C Duurland, Rivka de Jongh, Lianne Koets, Barbera Veldhuisen, Hilde Raaphorst, Annelies W. Turksma, Julian J. Freen‐van Heeren, Maurice Steenhuis, Theo Rispens, C Ellen van der Schoot, S. Marieke van Ham, Rene A. W. van Lier, Klaas P. J. M. van Gisbergen, Anja ten Brinke, Carolien E. van de Sandt”}]]

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Immunosenescence and cytomegalovirus infection are suggested to impair protective immunity against novel pathogens. Despite reduced total CD8+ Tnaïve cells in older CMV– and CMV+ individuals, our study found a broad and robust memory SARS-CoV-2-specific CD8+ T cell response in both younger and older convalescent COVID-19 donors regardless of CMV status. ABSTRACT Immunosenescence, age-related immune dysregulation, … Read more

A Critical Oversight in Immunology Research: The Prevalence of Complement Deficiencies in Mouse Models. África González‐Fernández

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Several mouse strains have a genetic deficiency in the fifth component of complement (C5). This defect affects research outcomes in areas such as allergies, autoimmunity, cancer, infectious diseases, and inflammation. ABSTRACT The complement system is a crucial component of the innate immune response, playing a vital role in defending the body against pathogens and maintaining … Read more

Vaginal Prevotella timonensis Bacteria Enhance HIV‐1 Uptake and Differentially Affect Transmission by Distinct Primary Dendritic Cell Subsets. [[{“value”:”Marleen Y. van Smoorenburg, Ester B. M. Remmerswaal, Celia Segui‐Perez, John L. van Hamme, Karin Strijbis, Teunis B. H. Geijtenbeek”}]]

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The bacterium Prevotella timonensis found in vaginal dysbiosis enhances the uptake of HIV-1 by primary dendritic cells. Virus is internalised into tetraspanin-rich compartments, which leads to efficient HIV-1 transmission to target cells. These results provide insight into how microbiota directly affect HIV-1 uptake thereby altering HIV-1 susceptibility. Created in BioRender. Geijtenbeek, T. (2025) https://BioRender.com/i89c292. ABSTRACT … Read more

Maximizing Insights, Minimizing Animal Testing: A Framework for Validating Multiparametric Single‐Cell Cytokine Analysis Panels. [[{“value”:”Johann Aleith, Wendy Bergmann‐Ewert, Brigitte Müller‐Hilke”}]]

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Multicolor spectral flow cytometry panels for cytokine expression analysis were optimized and validated without animal testing. Stimulated co-cultures of helper T cells, splenocytes, and fibroblast-like synoviocytes provided a complex cellular environment suitable for validating intracellular cytokine staining. This approach offers a more ethical alternative to commonly used animal disease models. ABSTRACT Intracellular cytokine labeling combined … Read more

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