European Journal of Immunology

CD8 T Cell Hyperfunction and Reduced Tumour Control in Murine Models of Advanced Liver Disease. [[{“value”:”Jood Madani, Jiafeng Li, Ma. Enrica Angela Ching, Agatha Vranjkovic, Katrina Jorritsma, Mohamed S. Hasim, Manijeh Daneshmand, Natasha Campeau, David A. Lawton, Salman Bagheri, Angela C. Cheung, Erin E. Mulvihill, Jennifer E. Bruin, Michele Ardolino, Angela M. Crawley”}]]

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Blood CD8 T cells in mice with advanced liver fibrosis exhibit IFN-γ and granzyme B hyperfunction, and animal responses to ectopic tumour challenge and immunotherapy are impaired. ABSTRACT Immune dysfunction in liver disease contributes to significant morbidities, depending on liver damage severity and aetiology. We previously reported long-lasting generalized CD8 T cell hyperfunction in chronic … Read more

Influence of SLAM Family Receptors in the NK‐Cell‐Mediated Surveillance of Lymphoblastic Acute Leukemia. [[{“value”:”Jacqueline Sánchez‐Herrera, Lucero Valenzuela‐Vázquez, Juan Carlos Nuñez‐Enriquez, Fernando Arellano‐Juvera, Elva Jiménez‐Hernandéz, Minerva Mata‐Rocha, Janet Flores‐Lujano, José Gabriel Peñaloza‐Gonzalez, César Alejandro Galván‐Díaz, José Refugio Torres‐Nava, Jorge Alfonso Martín‐Trejo, María de Lourdes Gutiérrez‐Rivera, Rosa Martha Espinosa‐Elizondo, Laura Elizabeth Merino‐Pasaye, Maria Luisa Pérez‐Saldívar, Luz Victoria Flores‐Villegas, Karina Anastacia Solís‐Labastida, María Raquel Miranda‐Madrazo, Gabriela Alicia Hernández‐Echáurregui, Darío Orozco‐Ruíz, Aurora Medina‐Sanson, Omar Alejandro Sepúlveda‐Robles, Haydeé Rosas‐Vargas, Ismael Mancilla‐Herrera, Luis R. Rodríguez‐Villalobos, Juan José Dosta‐Herrera, Javier A. Mondragón‐García, Alejandro Castañeda‐Echevarría, M. Guadalupe López‐Caballero, Sofía I. Martínez‐Silva, Juan Rivera‐González, Norma A. Hernández‐Pineda, Jesús Flores‐Botello, Jessica A. Pérez‐Gómez, M. Adriana Rodríguez‐Vázquez, Delfino Torres‐Valle, Jaime Á. Olvera‐Durán, Annel Martínez‐Ríos, Luis R. García‐Cortés, Carolina Almeida‐Hernández, Vilma Carolina Bekker‐Méndez, Leila Vera‐Ramirez, Oscar Zamudio‐Chávez, Ivan Martínez‐Duncker, Kevin P. Madauss, Jorge Meléndez‐Zajgla, André Veillette, Juan Manuel Mejía‐Arangure, Mario Ernesto Cruz‐Muñoz”}]]

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• SLAM family receptors regulate the susceptibility of hematopoietic stressed cells to NK cell-mediated cytotoxicity. • Leukemia cells might downregulate the expression of SLAM family receptors to avoid being recognized and lysed by NK cells. • NK cell engagers containing SLAM family receptors may be an important resource for the design of therapeutic strategies aiming … Read more

Effect of Aspirin Challenge on Innate Lymphoid Cells in Asthma Patients With Aspirin Hypersensitivity. [[{“value”:”Radosław Kacorzyk, Bogdan Jakiela, Alicja Maciejska, Agnieszka S. Węgrzyn, Adam Ćmiel, Marek Sanak, Lucyna Mastalerz”}]]

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In N-ERD patients, oral aspirin-induced bronchospasm is associated with increased blood group 1 innate lymphoid cells (ILC1s), decreased sputum eicosanoids, and increased urinary leukotriene E4 (LTE4), suggesting a potential role of blood ILC1s in aspirin-induced bronchoconstriction. ABSTRACT Previous studies confirmed increased group 2 innate lymphoid cell (ILC2s) count in nasal scrapings, alongside a reduced blood … Read more

PD‐L2 Inhibits Protective Immunity, Th2 Cell Functional Quality, and GATA‐3 Expression During Filarial Nematode Infection. [[{“value”:”Johanna A. Knipper, Sharon M. Campbell, Judith E. Allen, Matthew D. Taylor”}]]

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During filarial nematode infection with Litomosoides sigmodontis, PD-L2 down-regulates Th2 cell expression of GATA-3 and Th2 cytokines and enables parasite survival. Concurrently, B cells suppress protective immunity through a mechanism that does not involve PD-L2. ABSTRACT Filarial nematodes infect over 200 million people, predominantly stimulating a Type 2 immune response. Protective immunity takes decades to … Read more

Cover Story: Eur. J. Immunol. 8’25.

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Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more

Spatial Organisation of Tumour cDC1 States Correlates with Effector and Stem‐Like CD8+ T Cells Location. [[{“value”:”Cécile Piot, Mariana Pereira da Costa, Adi Biram, Carlos M. Minutti, Kok Haw Jonathan Lim, Mary Green, Ania Mikolajczak, Robert P. Jenkins, Lucy Meader, Michael D. Buck, Ana Cardoso, Neil Rogers, Erik Sahai, Caetano Reis e Sousa”}]]

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Using scRNAseq and spatial analysis, we analyse cDC1 states and spatial distribution in tumours during immune-mediated rejection. We identify two cDC1 activation states, each occupying different regions and associated with distinct CD8+ T cell populations. This reveals the spatial organisation of cDC1 states that may be key to anti-tumour immunity. ABSTRACT CD8+ T cells are … Read more

Immunological Impact of Oncolytic Adenoviruses On Cancer Therapy: Clinical Insights. [[{“value”:”Reza Nadafi, Wenliang Dong, Victor W. van Beusechem”}]]

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Conditionally replicating oncolytic adenoviruses (OAds) mediate cancer cell destruction while triggering robust immune responses. Clinical data reveal their ability to remodel the tumor microenvironment and enhance responsiveness when combined with other therapies. This review highlights immune-modulating effects of OAds in patients, with a focus on therapeutic implications and combination strategies. ABSTRACT Oncolytic immunotherapy, particularly using … Read more

Signal Transducer and Activator of Transcription 3 (STAT3) Variant p.K709N Causes Hyper‐IgE Syndrome Likely by Impaired STAT3‐Dimer Formation. [[{“value”:”Beate Hagl, Benedikt D. Spielberger, Betina Neumann, Simon J. Pelham, Dharmendra Pandey, Andreas Schlundt, Camille Barro, Anica Lechner, Christine Wolf, Elissa K. Deenick, Michael Sattler, Stuart G. Tangye, Simon Rothenfusser, Ellen D. Renner”}]]

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In a patient with the classical clinical phenotype of STAT3-hyper-IgE syndrome, we identified the previously unreported STAT3 variant p.K709N to be disease-causing. Molecular analyses revealed that STAT3 p.K709N exerts a dominant-negative effect, leading to impaired STAT3 dimerization and reduced STAT3 target gene expression. Source: Created in BioRender. Hagl B. (2025) https://BioRender.com/80tycxp. ABSTRACT STAT3-hyper-IgE syndrome (STAT3-HIES) … Read more

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