European Journal of Immunology

CD3xHER2 bsAb‐Mediated Activation of Resting T‐cells at HER2 Positive Tumor Clusters Is Sufficient to Trigger Bystander Eradication of Distant HER2 Negative Clusters Through IFNγ and TNFα. [[{“value”:”Chen‐Yi Liao, Patrick Engelberts, Michiel van Dijk, Annemieke Timmermans, John W. M. Martens, Elsa Neubert, Erik H.J. Danen”}]]

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Spatiotemporal aspects of bystander killing triggered by bispecific antibodies: (1) Resting T-cells recognize HER2+ tumors via CD3xHER2 bsAbs. (2) Local T-cell activation induces direct HER2+ tumor killing and IFNγ/TNFα release. (3) IFNγ/TNFα mediate paracrine killing of HER2− cells. (4) HER2− cells are eliminated in mixed (A) and distant (B) areas. ABSTRACT Bispecific antibodies (bsAbs) bridging … Read more

CST Is Epistatic With Shieldin to Limit DNA Double‐Strand Break End Resection and Promote Repair During Igh Class Switch Recombination. [[{“value”:”Chloé Lescale, Timea Marton, Amaury Vaysse, Guillaume Rode, Estelle Vincendeau, Alice Libri, François Dossin, Ludovic Deriano”}]]

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Here we show that CST and SHLD are required for CSR, while SHLD1-CTC1 interaction via the SHLD1 LDLP motif is dispensable. Mechanistically, we show that CTC1 and SHLD1 are epistatic during CSR, preventing genetic instability, exacerbated DSB end-resection, and microhomology-mediated end-joining at Igh switching sites. Created in Biorender.com. ABSTRACT Downstream of 53BP1-RIF1 lies the Shieldin … Read more

Modulation of Host Immunity by Microbiome‐Derived Indole‐3‐Propionic Acid and Other Bacterial Metabolites. [[{“value”:”Burkhard Schütz, Felix F. Krause, R. Verena Taudte, Mario M. Zaiss, Maik Luu, Alexander Visekruna”}]]

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The gut commensal Clostridium sporogenes metabolizes dietary tryptophan into indole-3-propionic acid (IPA). In this review, we highlight recent findings suggesting that IPA acts as an effective signaling molecule, modulating the function of Th17 lymphocytes and resulting in protection against intestinal inflammation. ABSTRACT In recent years, we have witnessed a rapidly growing interest in the intricate … Read more

Interleukin‐8/Matrix Metalloproteinase‐9 Axis Impairs Wound Healing in Type 2 Diabetes through Neutrophil Extracellular Traps‐Fibroblast Crosstalk. [[{“value”:”Dimitrios Tsilingiris, Anastasia‐Maria Natsi, Efstratios Gavriilidis, Christina Antoniadou, Ioanna Eleftheriadou, Ioanna A. Anastasiou, Anastasios Tentolouris, Evangelos Papadimitriou, Evgenios Eftalitsidis, Panagiotis Kolovos, Victoria Tsironidou, Alexandra Giatromanolaki, Maria Koffa, Nikolaos Tentolouris, Panagiotis Skendros, Konstantinos Ritis”}]]

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Neutrophil extracellular traps (NETs) in type 2 diabetes induce a pro-fibrotic but functionally impaired phenotype in cutaneous fibroblasts, associated with collagen breakdown by NET-bound MMP-9. IL-8 released in NETs promotes its own expression in both neutrophils/fibroblasts and neutrophil MMP-9 production, creating positive feedback loops that hinder wound healing. ABSTRACT Neutrophils interact with and activate fibroblasts … Read more

PLC and PAD2 Regulate Extracellular Calcium‐Triggered Release of Macrophage Extracellular DNA Traps. [[{“value”:”Neha Mishra, Magdalena Mohs, Nico Wittmann, Stefan Gross, Paul R. Thompson, Lukas Bossaller”}]]

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Extracellular calcium induces MET release from human macrophages. Concurrently, extracellular calcium activates the NLRP3 inflammasome. Citrullinated histones, MMP12, MPO and ASC specks are bound to METs and are released by rupture of the plasma membrane, where they exhibit bactericidal properties. ABSTRACT Macrophages can respond to infection or cellular stress by forming inflammasomes or by releasing … Read more

Metabolic Reprogramming in Stromal and Immune Cells in Rheumatoid Arthritis and Osteoarthritis: Therapeutic Possibilities. [[{“value”:”Órlaith C. Henry, Luke A. J. O’Neill”}]]

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Immune cells and stromal cells undergo metabolic reprogramming in both rheumatoid and osteoarthritis. This review summarises current evidence on the metabolic changes within and the crosstalk between immune and stromal cells in these diseases. In addition, we explore the therapeutic potential of targeting metabolic processes for the treatment of arthritis. ABSTRACT Metabolic reprogramming of stromal … Read more

IgA2 ACPA Drives a Hyper‐Inflammatory Phenotype in Macrophages via ATP Synthase and COX2. [[{“value”:”Luís Almeida, Alice Bacon, Mohan Ghorasaini, Alwin J. van der Ham, René E. M. Toes, Martin Giera, Bart Everts”}]]

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IgA autoantibodies have been implicated in promoting inflammation associated with rheumatoid arthritis by engaging Fc receptors on myeloid cells. However, underlying mechanisms are still poorly defined. Here, we identified immune complexed IgA2, but not IgA1, to induce hyper-inflammatory macrophages, and that it is dependent on ATP synthase and COX2 activity. ABSTRACT IgA can form immune … Read more

Expansion of Interleukin‐22‐Producing Type 3 Innate Lymphoid Cells in the Gut of Tristetraprolin‐Deficient Mice. [[{“value”:”Bérengère de de Toeuf, Maxime Melchior, Caroline La, Aresio Villanueva Alcantara, Abdulkader Azouz, Vincent Martens, Céline La, Ingrid Dubois, Sylvie Vande Velde, Lara Meyer, Muriel Nguyen, Séverine Thomas, Frédérick Libert, Laure Dumoutier, Perry J. Blackshear, Stanislas Goriely”}]]

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TTP controls the mRNA stability of multiple inflammatory cytokines. Despite a multiorgan inflammatory phenotype, TTP-deficient mice are protected from experimental colitis, in part, through the expansion of IL-22-producing ILC3 in the gut. ABSTRACT Tristetraprolin (TTP, encoded by Zfp36) is an RNA-binding protein that plays a major role in the control of inflammation. Zfp36−/− mice spontaneously … Read more

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