European Journal of Immunology, Volume 55, Issue 8, August 2025.
European Journal of Immunology, Volume 55, Issue 8, August 2025.
• Dysregulated HLA-DR expression on γδ T cells and impaired functionality of αβ T cells were found in the bone marrows of AML patients. • The ex vivo-expanded donor γδ T cells with high expression of HLA-DR facilitated the cytotoxic effect of αβ T cells. ABSTRACT In addition to exhibiting significant cytotoxic capabilities, γδ T … Read more
Exploiting a high-dimensional mass cytometry approach, we demonstrate that CD56+ lymphocytes promote Mycobacterium tuberculosis dormancy by delivering granulysin, a cytotoxic effector molecule with known antimicrobial activity. ABSTRACT Human tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) remains a global public health threat. Granulomas constitute a hallmark of TB pathogenesis that can clear, contain, or exacerbate an … Read more
SOCS mimetics target dysregulated cytokine signaling, offering promising immunomodulatory therapy for autoimmune encephalitis by suppressing cytokine signaling, reducing neuroinflammation, and preserving blood–brain barrier integrity. ABSTRACT Autoimmune encephalitis (AE) is a debilitating neurological condition characterized by the immune system’s attack on neuronal cells, often leading to significant cognitive and neurological impairments. Autoantibodies, particularly those targeting N-methyl-D-aspartate … Read more
T cell receptor engagement induces coordinated actin and microtubule cytoskeletal remodeling at the immunological synapse. This dynamic reorganization generates mechanical forces that sustain TCR signaling and promote effective T cell activation. The SSH1–cofilin–LIMK1 signaling pathway plays a pivotal role in regulating cytoskeletal dynamics during this process. ABSTRACT During T cell immune responses, actin dynamics facilitates … Read more
This study discovered the small molecule 9-methoxy-6-methylindolo[3,2-b] quinoxaline (IFA005) as a potent immunomodulator capable of converting human memory CD4⁺ T cells into functional Foxp3⁺ regulatory T cells. IFA005 suppresses Th2 cytokines (IL-4, IL-5, and IL-13) and promotes the iTreg phenotype by inhibiting Wnt/β-catenin signaling through NKD2 upregulation. These findings support small-molecule-mediated Wnt/β-catenin blockade as a … Read more
Autoantibodies in ulcerative colitis target neutrophil and mucosal components, including NETs, goblet cells, and integrins-offering insight into disease pathophysiology. Understanding these interactions may support biomarker development, enable earlier diagnosis, aid patient stratification, and drive future therapeutic innovation. ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by immune dysregulation and epithelial barrier dysfunction. … Read more
We investigated neutrophil heterogeneity in patients with systemic lupus erythematosus and identified increased surface levels of LAMP1 (CD107a). Stimulation of healthy donor neutrophils led to increased surface LAMP1. Urine and serum soluble LAMP1 levels were increased in patients, especially those with proliferative lupus nephritis. ABSTRACT Lupus nephritis (LN) is a severe manifestation of systemic lupus … Read more
Testosterone suppresses Th17 cell differentiation and alleviates Th17-driven skin inflammation in an experimental psoriasis model. Mechanistically, testosterone binds to the ligand-binding domain (LBD) of RORγt, inhibiting its transcriptional activity required for IL-17 production and other Th17-cell-associated proinflammatory gene expression. These findings provide a mechanistic explanation for testosterone’s immunosuppressive effects and offer insights into the gender … Read more
