The complement system plays a crucial role in immune defense, and factor D deficiency is a rare immunodeficiency associated with life-threatening bacterial infections. We report two new cases of complete factor D deficiency, including the first described in a Down syndrome patient, highlighting the need to investigate complement deficiencies in patients with secondary immunosuppression. Given … Read more

Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more

European Journal of Immunology, Volume 55, Issue 3, March 2025.

• We present a model for inducible deletion of Gads (GadsiKO), resulting in chimeric mice. • The relative frequency of Gads-deficient (red) thymocytes decreases at Gads-dependent developmental checkpoints. • Gads promotes death by neglect and suppresses the aberrant progression of unselected thymocytes to the CD4 SP compartment. ABSTRACT Thymocyte β-selection and positive-selection depend on TCR … Read more

VSTM1 is an inhibitory receptor expressed on myeloid cells recognizing endogenous and microbial ligands, classifying it as a pattern recognition receptor. During homeostasis, VSTM1 inhibits Fc-mediated reactive oxygen species (ROS) and neutrophil extracellular trap formation (NET) in granulocytes and monocytes. After activation of the Fc receptor by, for example, an infection, VSTM1 is downregulated and … Read more

Trametinib was originally developed as an anticancer reagent, but recent reports have suggested Trametinib may have potential as an immunosuppressant. Our data suggested that trametinib suppressed T-cell proliferation as well as cancer proliferation through G1 arrest and apoptosis. Trametinib suppressed CD4 and CD8 T cell proliferation by inducing G1 arrest and apoptosis along with suppression … Read more

In pDCs, BTK-inhibition (BTKi) blocks the IFN-α production via TLR-9, but not via TLR-7. Upon TLR-7 stimulation, BTKi enhances the production of IFN-α by blocking the inhibitory BDCA-2 pathway. This might explain partially the failure of BTKi in SLE and is of interest for BTKi trials in multiple sclerosis.

This review explores the technical advances in single-cell multi-omics technologies alongside the parallel development of generative AI tools to uncover biological insights. By integrating these innovative approaches, we highlight the potential to identify diagnostic, prognostic and outcome biomarkers, enhance patient stratification systems and discuss future prospects for advancing precision medicine and personalised therapeutic strategies. ABSTRACT … Read more

Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more

European Journal of Immunology, Volume 55, Issue 2, February 2025.