European Journal of Immunology – Page 24

Innate immunity champions: The diverse functions of macrophages. [[{“value”:”Francesca Biscu, Anissa Zouzaf, Donatella Cicia, Clare Pridans, Gianluca Matteoli”}]]

30 de September de 202429 de September de 2024 by inmunoadmin

This review highlights the pivotal role of macrophages in regulating tissue homeostasis and immune response during disease. Advanced omics technologies reveal their adaptability within tissue-specific niches, influenced by their metabolic states. Understanding these dynamics is crucial for developing targeted therapies that modulate macrophage function, offering innovative strategies for managing chronic inflammatory conditions. Abstract Macrophages are … Read more

Reduction in mucosal‐associated invariant T cells (MAIT) in APECED patients is associated with elevated serum IFN‐γ concentration. [[{“value”:”Iivo Hetemäki, Joona Sarkkinen, Huai Hui Wong, Nelli Heikkilä, Saila Laakso, Simo Miettinen, Mikko I. Mäyränpää, Outi Mäkitie, T Petteri Arstila, Eliisa Kekäläinen”}]]

30 de September de 202429 de September de 2024 by inmunoadmin

We found a reduced frequency of circulating mucosal-associated invariant T cells (MAITs) in patients with APECED with a clear negative correlation to inflammatory markers CRP, IL-18, and IFN-γ. These findings suggest that the decrease in MAITs is secondary to type 1 immune dysregulation present in the disease. Abstract Mucosal-associated invariant T cells (MAIT) are innate-like … Read more

γδ T cells in immune‐mediated kidney disease. [[{“value”:”Alex Waterhölter, Christian F. Krebs, Ulf Panzer”}]]

30 de September de 202429 de September de 2024 by inmunoadmin

This review summarizes the current knowledge about γδ T cells in immune-mediated kidney diseases. We highlight that γδ T cells are associated with an aggravation of tissue damage through direct pathways and interactions with other leukocyte subsets . Abstract Immune-mediated kidney diseases, including glomerulonephritis (GN), represent a diverse spectrum of disorders characterized by inflammation within … Read more