Striking the Right Chord at EJI: Introducing Editor‐in‐Chief Matteo Iannacone and the Seamless Transfer Policy. [[{“value”:”Matteo Iannacone, Nadja Bakocevic”}]]
European Journal of Immunology, Volume 55, Issue 1, January 2025.
European Journal of Immunology
The Anti‐Human P2X7 Monoclonal Antibody (Clone L4) Can Mediate Complement‐Dependent Cytotoxicity of Human Leukocytes. [[{“value”:”Amal Elhage, Debbie Watson, Ronald Sluyter”}]]
The anti-P2X7 monoclonal antibody (clone L4) mediates complement-dependent cytotoxicity of human leukocytes. This process preferentially targets leukocytes with high cell surface P2X7, such as monocytes and dendritic cells, presenting a new strategy to reduce P2X7 immune functions. ABSTRACT P2X7 is an extracellular adenosine 5′-triphosphate (ATP)-gated cation channel that plays various roles in inflammation and immunity. … Read more
The VEGF‐Mediated Cytoprotective Ability of MIF‐Licensed Mesenchymal Stromal Cells in House Dust Mite‐Induced Epithelial Damage. [[{“value”:”Hazel Dunbar, Ian J. Hawthorne, Courteney Tunstead, Molly Dunlop, Evelina Volkova, Daniel J. Weiss, Claudia C. dos Santos, Michelle E. Armstrong, Seamas C. Donnelly, Karen English”}]]
Licensing of MSCs with MIF requires CXCR4 receptor binding. Enhanced VEGF production by MIF-licensed MSCs promotes wound healing in vitro and can be blocked using the VEGFR2 inhibitor SU-5416. MIF-licensed MSC conditioned medium significantly reduced goblet cell hyperplasia in house dust mite-driven allergic airway inflammation in vivo. ABSTRACT Enhancing mesenchymal stromal cell (MSC) therapeutic efficacy … Read more
Issue Information: Eur. J. Immunol. 1’25.
European Journal of Immunology, Volume 55, Issue 1, January 2025.
Direct Inhibitory Effect of HTLV‐1‐Infected T Cells on the Production of Anti‐Ro/SS‐A Antibody by B Cells from Patients with Sjögren’s Syndrome. [[{“value”:”Kinya Nagata, Masako Tsukamoto, Yosuke Nagasawa, Noboru Kitamura, Hideki Nakamura”}]]
HTLV-1-infected T-cell lines suppress IgG and autoantibody production from B cells of healthy donors and patients with Sjögren’s syndrome through cell-to-cell contact and some humoral factors. ABSTRACT The reasons for the low frequency of anti-Ro/SS-A antibody in patients with HTLV-1-associated myelopathy complicated with Sjögren’s syndrome (SS) are unclear. In this study, we investigated whether HTLV-1-infected … Read more
Cover Story: Eur. J. Immunol. 1’25.
Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more
Survival of Human Bone Marrow Plasma Cells In Vitro Depends on the Support of the Stromal Cells, PI3K, and Canonical NF‐kappaB Signaling. [[{“value”:”Zehra Uyar‐Aydin, Shirin Kadler, Roland Lauster, Sina Bartfeld, Mark Rosowski”}]]
This study established a 21-day in vitro culture system for human long-lived plasma cells (LLPCs), demonstrating their survival and antibody secretion depend on stromal cell contact. PI3K and NF-kappaB pathways were crucial for LLPC survival, aligning with findings in mice. This model advances the understanding of human LLPC biology. ABSTRACT Contrary to short-lived plasma cells, … Read more
Pathogenic and Nonpathogenic Antibody Responses in Allergic Diseases. [[{“value”:”Marc Ehlers, Friederike Jönsson”}]]
Allergen-specific antibodies can be detected in a large proportion of individuals. Still, only a fraction suffer from clinical signs of allergic disease, and of these, some, but not all, will develop more severe forms of the disease over time or respond to allergen-specific immunotherapy. Here, we review the concept of nonpathogenic versus pathogenic antibody responses … Read more
Ubiquitin‐Conjugating Enzyme Ubc13 in Macrophages Suppresses Lung Tumor Progression Through Inhibiting PD‐L1 Expression. [[{“value”:”Siying Sun, Jun Ni, Jiamin Liu, Juofang Tan, Runsen Jin, Hecheng Li, Xuefeng Wu”}]]
Sun et al. demonstrate that deficiency of macrophage-intrinsic Ubc13 increases Akt activation and PD-L1 expression, which triggers macrophage protumoral polarization and lung tumor progression. Ubc13-depletion in macrophage also increases infiltration of myeloid-derived suppressor cells and decreases proliferative and effector function of CD8+ T lymphocytes in the tumor microenvironment. ABSTRACT Tumor cell-intrinsic ubiquitin-conjugating enzyme Ubc13 promotes tumorigenesis, … Read more
Researcher Reflections—Inspiring Paths in Academia. [[{“value”:”Annika Hausmann, Ioana Sandu, Rami Bechara, Liv Eidsmo, Adrian Liston, Shruti Naik, Charlotte L. Scott, Matteo Villa, Eduardo Villablanca, Natalia Muñoz‐Wolf”}]]
ABSTRACT The journey of early-career researchers (ECRs) in immunology is marked by many challenges but also exciting prospects. Here we bring a snapshot of the recent ECR workshop organized by the Young European Federation of Immunology Societies (yEFIS) during the 7th European Congress of Immunology (ECI), which took place in Dublin Ireland from September 1 … Read more