European Journal of Immunology

Biomarkers of vascular integrity and inflammatory processes are involved in different types of angioedema, highlighting the potential importance of complement/lectin system interactions with granulocytes in understanding angioedema triggers. The C1s/C1-INHc-to-MASP-1/C1-INHc ratio could be used as a diagnostic tool to distinguish C1-INH-HAE from other HAE subtypes. ABSTRACT The precise molecular mechanisms underlying angioedema attacks in cases … Read more

Mycobacterium tuberculosis infection of human monocyte-derived macrophages during febrile conditions significantly induces heat shock protein-70 (HSP70) expression, which modulates cytokine responses. This highlights that pathophysiological responses, such as fever, regulate tuberculosis immunopathology. ABSTRACT Fever is a common clinical symptom in patients with tuberculosis (TB). During fever, heat-shock proteins (HSPs), such as HSP70, are expressed, which … Read more

The Sialic acid/Siglec axis is emerging as an important target in the TME. We explore the role of sialylation within stromal-rich, immunosuppressive TMEs, focusing on how specific sialic acid/Siglec interactions dictate innate and adaptive immune responses. We propose that targeting glycoimmune checkpoints as a mechanism may overcome stromal-mediated therapy resistance and enhance anti-tumour immunity. ABSTRACT The … Read more

The T cell response induced by SARS-CoV-2 vaccines is an essential component of immune protection against COVID-19. Multiparametric flow cytometry analysis emerges as a valuable tool for in-depth assessment of T cell phenotype nuances that occur after booster vaccination, such as a fifth dose of an inactivated SARS-CoV-2 vaccine. Figure created with BioRender.com.

Innate lymphoid cells contribute to the health of the uterine microenvironment, which is important for global health. Endometriosis affects 10% of women of fertile age. Millions of pregnancies have adverse outcomes every year: miscarriages, pre-eclampsia, fetal growth restriction, preterm labour and stillbirth — all due to defective placentation. Abnormal fetal growth exposes newborns to greater … Read more

Ak2 deficiency leads to impaired development of T and B cells in mice, corresponding to impaired lymphopoiesis of reticular dysgenesis (AK2 deficiency) in humans. In contrast to the human pathophysiology, Ak2 deficiency is lethal in mice due to severe anaemia, and murine myelopoiesis is less affected. ABSTRACT Reticular dysgenesis (RD) is a rare genetic disorder … Read more

Human interferon-ω (IFN-ω) is produced by monocytes and plasmacytoid dendritic cells in response to inflammatory stimuli. It confers antiviral protection to lung epithelial cells against SARS-CoV-2 infection and enhances the effector functions of antigen-specific CD8⁺ T cells. ABSTRACT The type-I interferon family is well known for its critical role in innate immunity. It comprises several … Read more

Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more

nuTCRacker aims to predict unseen αβTCR-peptide-HLA-I affinity. Predictions are successful for only a subset of unseen peptides although they are better than the benchmarked methods. Predictions are tested on both novel and published T cell assays. ABSTRACT The ability to predict which antigenic peptide(s) the αβTCR of a given CD8+ T-cell clone can recognise would … Read more

European Journal of Immunology, Volume 55, Issue 7, July 2025.