The role of CD4+ T cells in promoting cellular and humoral immunity induced by novel mRNA–LNP and adenovirus vector vaccine technologies is incompletely understood. Surprisingly, we identified a discordant need for CD4+ T cell help based on both vaccine platform and arm of adaptive immunity examined. These data provide further evidence of the unique biology … Read more

For each patient in the NSCLC cohort, TCR sequences were converted into numerical vectors using the TCR2Vec model and projected onto a 2D landscape. The aggregated fractions of anti-LAA TEGs per patient were calculated. ICB responders had over-represented anti-LAA TEGs compared to non-responders.

European Journal of Immunology, EarlyView.

In the steady state, naïve CD4 T cells can develop into memory phenotype (MP) cells. We discovered that MP T cells include a subpopulation of Tfh cells. MP Tfh cells share key markers with pathogen-induced memory Tfh cells and can support germinal center formation and antibody responses to infection. ABSTRACT Pathogen-induced memory Tfh cells are … Read more

This review addresses how fibroblastic reticular cells (FRCs) undergo metabolic reprogramming in response to infections, autoimmune diseases, and cancer, adjusting their glycolysis, oxidative phosphorylation, and fatty acid metabolism to modulate immune functions. These metabolic shifts in FRCs highlight potential therapeutic strategies to improve immune regulation across various disease contexts. ABSTRACT Fibroblastic reticular cells (FRCs) are … Read more

Working on the 1000-donor Milieu Interieur cohort with ex vivo whole blood stimulation, we demonstrate that naturally occurring cytokine autoantibodies (c-aAb) in healthy donors can neutralize cytokine availability and regulate proinflammatory gene expression. ABSTRACT Autoantibodies against cytokines (c-aAb) have been implicated in the pathophysiology of autoimmune diseases, and a variety of infections. In addition, several … Read more

This study investigates the microbiome as a potential factor underlying the apparent differences in immune stimulation required for HLH induction in perforin-deficient mice compared to FHL-2 patients. Using PKO-Wildlings, we show that while immune activation by natural microbiota is not sufficient to induce HLH, it can influence manifestations of LCMV-induced disease. ABSTRACT Primary hemophagocytic lymphohistiocytosis … Read more

Thymic NC-derived mesenchymal cells produce factors, including Flt3L and Periostin, after irradiation. Depletion of NC-derived mesenchyme reduces these factors, decreases the abundance of ETPs, and impairs thymic reconstitution postirradiation. The addition of Flt3L and Periostin after NC-derived mesenchyme depletion restores reconstitution, highlighting the importance of NC-derived mesenchyme in thymus regeneration. ABSTRACT Reconstitution of the thymus … Read more

Multimodal single-cell RNA sequencing identified a population of CD8+ T cells elevated in tumor tissue enriched for interferon-stimulated genes (ISG). These ISG cells are clonally related to a population of Granzyme K (GZMK)-expressing CD8+ T cells. However, unlike GZMK-expressing T cells, ISG cells were transcriptionally inert in response to in vitro stimulation. Created in BioRender.com … Read more

Depending on whether the interactions occur in vitro or in vivo, physical binding between two B cells with complementary BCRs leads to distinct outcomes for the participating cells. In vitro, both the Id+ B cell and the complementary anti-idiotypic B cell undergo apoptosis. In vivo, follicular αId B cells expand, whereas marginal zone Id+ B … Read more