European Journal of Immunology

mTOR Modulates NLRP3 Inflammasome Activation via Nuclear Translocation and STAT1 Inhibition. [[{“value”:”Alvaro González‐Dominguez, Shuling Zhang, Daniel Boy‐Ruiz, Daniel Connors, Raquel de la Varga‐Martínez, Beverly A. Mock, Mario D. Cordero”}]]

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mTOR is binding to NLRP3 until a NLRP3-inflammasome stimulus. After activation, mTOR is translocated to the nucleus to inhibit STAT1 and support the NLRP3 inflammasome assembly and activation. mTOR inhibition with rapamycin reduces mTOR presence in the nucleus and increases STAT1 which represses NLRP3 inhibiting the activation. ABSTRACT The NLRP3 inflammasome has emerged as an … Read more

Butyrate Selectively Targets Super‐Enhancers and Transcriptional Networks Associated with Human Mast Cell Function. [[{“value”:”Jelle Folkerts, Marjolein J. W. de Bruijn, Wilfred F. J. van IJcken, Rudi W. Hendriks, Ralph Stadhouders”}]]

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Butyrate, a short-chain fatty acid (SCFA) derived from dietary fibers, selectively inhibits human mast cell activation by targeting transcription start sites (TSS) and super-enhancers regulating key mast cell genes. Local histone hypoacetylation induced by butyrate likely drives transcriptional suppression and reduced degranulation, providing new insights into how SCFA modulates inflammation. ABSTRACT Mast cells are key … Read more

Cover Story: Eur. J. Immunol. 6’25.

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Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more

Inhibition of Melanoma Growth by Ex Vivo Expanded Tumor‐Specific CD8+ T Cells Is Dependent on the Configuration of Nanoscale Artificial APCs. [[{“value”:”Antara Mondal, Faisal Jamal, Arpita Das, Arnab Kumar Sahoo, Khushboo Chaudhary, Sarmili Chowdhury, Aakriti Jha, Santiswarup Singha”}]]

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A critical configuration of nanoscale a-APCs displaying high valency of tumor-specific peptide-MHCs and co-stimulatory molecules is essential for expanding antigen-specific CD8+ T-cells ex vivo at high yield with profound production of cytolytic molecules, resulting in enhanced therapeutic potential for inhibiting the growth of solid tumors. ABSTRACT Adoptive T-cell therapy is an emerging immunotherapeutic strategy for … Read more

The Inactive X Chromosome: A Genetic Driver of Female‐Biased Rheumatic Autoimmune Disorders?. [[{“value”:”Léa Ferrayé, Mélissa Nieucel, Magali Savignac, Julie Chaumeil, Jean‐Charles Guéry”}]]

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Recent works indicate that several X-linked genetic mechanisms contribute to the female predisposition for autoimmune diseases. Here, we review the recent findings that underscore the significance of the alteration of X chromosome inactivation (XCI) maintenance and the putative role of the long noncoding XIST/Xist RNA in this process but also as a sex-biased source of … Read more

Advances in Regulatory Cell Therapy for Type 1 Diabetes: Emerging Strategies and Future Directions. [[{“value”:”Laura Passerini, Aurora Forlani, Silvia Gregori”}]]

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Regulatory cell-based therapies, encompassing stem-like cells, T regulatory cells, and tolerogenic dendritic cells, have already been tested in clinical trials for reversing autoimmunity in type 1 diabetes. These early successes opened new perspectives for next-generation antigen-specific strategies to achieve durable and self-sustaining immune tolerance. ABSTRACT Type 1 diabetes (T1D) is an autoimmune disorder characterized by … Read more

RSV‐Induced Regulation of DC via H3K4 Demethylase KDM5b. [[{“value”:”Mohamed M. Mire, Llilian A. Martinez, Ashley M. Cortes, Susan Morris, Andrew Rasky, Catherine Ptaschinski, Nicholas W. Lukacs”}]]

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Summary of findings showing proposed effects of RSV-induced Kdm5b in the DC resulting in the exasperated lung pathology seen with RSV related to modified type 1 responses. ABSTRACT We previously observed an upregulation of Kdm5b, an H3K4 demethylase, following RSV infection of DCs that regulates key innate cytokines, including Type I IFN and TNF. As … Read more

Adaptive NKG2C+ NK cells in cytomegalovirus seropositive individuals predominantly lack NKR‐P1A receptor expression. [[{“value”:”Mohamad Basem Alkassab, Fareeha Ajmal Shaikh, Caroline Hamm, Mir Munir A. Rahim”}]]

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Expansion of the adaptive NKG2C+ NK cells during cytomegalovirus (CMV) infection is restricted to the subset lacking NKR-P1A receptor. This is associated with increased proliferation of NKR-P1A‒, but not NKR-P1A+, NK cells in CMV-infected individuals. ABSTRACT The impact of cytomegalovirus (CMV) infection in shaping natural killer (NK) cell receptor (NKR) repertoire highlights the importance of … Read more

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