European Journal of Immunology

Natural Killer Cells Are Dispensable for Virus Control in Rag2−/− Mice During Primary RSV Infection. [[{“value”:”Joy Nakawesi, Tammie Sow Tao Min, Cecilia Johansson”}]]

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Rag2−/− mice are unable to clear respiratory syncytial virus (RSV) infection, despite an earlier recruitment of natural killer (NK) cells to the lungs compared with wild-type controls. Furthermore, depletion of NK cells does not affect viral load, indicating that alternative innate anti-viral mechanisms may compensate in the absence of adaptive immunity. ABSTRACT Respiratory syncytial virus … Read more

Cover Story: Eur. J. Immunol. 9’25.

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Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more

Baseline Single‐Cell Differences in Polyfunctionality Between Systemic Autoinflammatory Diseases Patients and Healthy Controls. [[{“value”:”Aline Linder, Farah Diab, Loïc de Pontual, Irina Giurgea, Klaus Eyer”}]]

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Dysregulated cytokine secretion and signaling underlie systemic autoinflammatory diseases (SAIDs). Here, we characterized immune dysregulation in SAID patients by profiling cytokine secretion at the single-cell level, establishing measurements for secretion dynamics and cellular polyfunctionality, compared with healthy controls, revealing natural variability within immune responses between donors.

Sustained Lung Inflammation Post‐SARS‐CoV‐2 Infection in Mice Is Associated with Increased Pulmonary T Cells. [[{“value”:”Sophie Y. Guan, Patricia P. Ogger, Ana Farias, Minerva Garcia Martín, Joy Nakawesi, Olivia Bedard, Candice Baker, Nadia Rosenthal, Cecilia Johansson”}]]

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Low-dose SARS-CoV-2 infection in 129 × C57BL/6-K18-hACE2 mice induces sustained lung inflammation. Despite complete viral clearance and full recovery of body weight by day 8 post-infection, both CD4+ and CD8+ T cells remained detectable in the lungs up to day 28 post infection, indicating ongoing immune activity. ABSTRACT Many SARS-CoV-2 patients experience chronic pulmonary symptoms … Read more

SOCS Proteins: Key Players in Immune Regulation During SARS‐CoV‐2 Infection. [[{“value”:”Juber Herrera‐Uribe, Nigel J. Stevenson”}]]

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SOCS proteins are key modulators of cytokine signaling during SARS-CoV-2 infection, balancing antiviral responses and inflammation. The virus differentially regulates SOCS expression across tissues and disease stages, exploiting SOCS regulatory function to suppress antiviral pathways. This regulatory role positions SOCS proteins as potential targets for stage-specific immunomodulatory therapies. ABSTRACT Suppressor of cytokine signaling (SOCS) proteins … Read more

Mast Cell Phenotypic Heterogeneity Impacts the Interplay with Pathogenic Salmonella Typhimurium Bacteria. [[{“value”:”Christopher von Beek, Grisna I. Prensa, Julia H. M. Andersson, Gunnar Pejler, Mikael E. Sellin”}]]

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Mast cell phenotypic features influence anti-bacterial response. Connective tissue-like mast cells sense Salmonella through combined Toll-like-receptor (TLR) signaling and recognition of Type-III-secretion-system mediated invasion. By contrast, due to low TLR expression, mucosal-like mast cells fail to respond to extracellular Salmonella, but their abundant granules limit intracellular colonization by invasive bacteria. ABSTRACT Mast cells (MCs) lodge … Read more

TLR9‐Driven S‐Palmitoylation in Dendritic Cells Reveals Immune and Metabolic Protein Targets. [[{“value”:”Juan N. Quiroz, Malte Sielaff, Daria Kondrateva, Fatima Boukhallouk, Gloria J. Godoy, Cecilia R. Molina, Brecht Moonen, Claudia C. Motran, Jeroen Bogie, Hugo D. Luján, Stefan Tenzer, Tim Sparwasser, Luciana Berod”}]]

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Click chemistry–based proteomics revealed dynamic remodeling of the S-palmitoylated proteome in dendritic cells upon TLR9 activation. Transcriptomics identified TLR9-driven regulation of ZDHHC genes, including Zdhhc9. Genetic approaches uncovered potential ZDHHC9-dependent targets. Functional studies exposed key methodological limitations in investigating S-palmitoylation in dendritic cells. ABSTRACT Dendritic cells (DCs) rely on Toll-like receptor 9 (TLR9) to detect … Read more

BMP Signaling Alleviates Allergic Airway Inflammation by Controlling Group 2 Innate Lymphoid Cells Homeostasis. [[{“value”:”Shan Yue, Huihui Li, Zhiqiang Yan, Mengying Xie, Mengyuan Dai, Mingying Zhang, Wei Xu”}]]

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BMPR2 deficiency enhances ILC2 proliferation and exacerbates type 2 airway inflammation. BMP4 restrains ILC2 expansion via canonical BMP signaling, alleviating inflammation in a BMPR2-dependent manner. ABSTRACT Recent studies have highlighted the important role of bone morphogenetic proteins (BMPs) in immunoregulation. Our earlier work identified the expression of BMP receptors on lymphoid progenitors and group 2 … Read more

Mast Cells Are Not Essential for Pubertal Mammary Gland Branching. [[{“value”:”Simran Kapoor, Clara M. Munz, Jimmy Marsden, Cyril Carvalho, Holly Tinsley, Marlene Magalhaes Pinto, Bert Malengier‐Devlies, Solvig Becker, Guillaume Seuzaret, Katelyn Patatsos, Ramazan Akyol, Amy B. Pederson, Gillian Wilson, Marc Dalod, Rebecca Gentek”}]]

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Mast cells colonise tissues during development and may be involved in maturation processes. In the mammary gland, they are thought to promote pubertal branching morphogenesis. Using new Kit-independent models that are more mast cell-specific, we demonstrate that neither constitutive deficiency nor induced depletion at puberty impairs mammary gland branching. Mast cells are thus not essential … Read more

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