European Journal of Immunology

Signal Transducer and Activator of Transcription 3 (STAT3) Variant p.K709N Causes Hyper‐IgE Syndrome Likely by Impaired STAT3‐Dimer Formation. [[{“value”:”Beate Hagl, Benedikt D. Spielberger, Betina Neumann, Simon J. Pelham, Dharmendra Pandey, Andreas Schlundt, Camille Barro, Anica Lechner, Christine Wolf, Elissa K. Deenick, Michael Sattler, Stuart G. Tangye, Simon Rothenfusser, Ellen D. Renner”}]]

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In a patient with the classical clinical phenotype of STAT3-hyper-IgE syndrome, we identified the previously unreported STAT3 variant p.K709N to be disease-causing. Molecular analyses revealed that STAT3 p.K709N exerts a dominant-negative effect, leading to impaired STAT3 dimerization and reduced STAT3 target gene expression. Source: Created in BioRender. Hagl B. (2025) https://BioRender.com/80tycxp. ABSTRACT STAT3-hyper-IgE syndrome (STAT3-HIES) … Read more

Aging and Viral Evolution Impair Immunity Against Dominant Pan‐Coronavirus‐Reactive T Cell Epitope. [[{“value”:”Lucie Loyal, Karsten Jürchott, Ulf Reimer, Lil Meyer‐Arndt, Larissa Henze, Norbert Mages, Jak Kostrzanowski, Bernhard Reus, Maike Mangold, Beate Kruse, Manuela Dingeldey, Birgit Sawitzki, Janine Michel, Marica Grossegesse, Karsten Schnatbaum, Holger Wenschuh, Andreas Nitsche, Nils Lachmann, Bernd Timmermann, Claudia Giesecke‐Thiel, Julian Braun, Florian Kern, Andreas Thiel”}]]

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The immunodominant pan-coronavirus epitope iCope spans amino acids 816–830 within the fusion domain of the SARS-CoV-2 spike glycoprotein. This region exhibits a comparatively low mutation rate, especially when contrasted with the receptor-binding domain (RBD). Antigen-specific T cell responses against iCope are detectable even in unexposed individuals, are modestly enhanced following SARS-CoV-2 infection, and are robustly … Read more

Immunogenicity‐Guided Design of an Acinetobacter baumanii Vaccine. [[{“value”:”Chenghua Zhu, Shuaiyuan Liang, Ning Yang, Shan Li, Jianpeng Xue, Runlu Zhou, Xiuwen Hong, Sixi Chen, Nan Gao, Qiang Du, Jianling Huang, Ganzhu Feng, Xingran Du”}]]

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Schematic diagram of DCpep-NM-PLGA-rOmpW preparation and its immunoprotective effects on acute lethal pneumonia. This study developed a biomimetic nanovaccine (DCpep-NM-PLGA-rOmpW) against A. baumannii. The nanoparticle-delivered multiepitope vaccine induced robust Th1/Th17 and antibody responses, demonstrating significant protection in a lethal pneumonia model. ABSTRACT The development of vaccines represents a promising and safe strategy to combat multidrug-resistant … Read more

Machine Learning Reassessment of Serum Immune Factors Shows No Unique Immune Profiles Linked to Disease Outcomes in SARS‐CoV‐2‐infected Patients at Hospital Admittance. [[{“value”:”Stefania Rossi, Imerio Capone, Enrico Cabri, Anna Giabelli, Ilaria Rossoni, Giulia Romagnoli, Stefano M. Santini, Cinzia Marcantonio, Roberto Giuseppetti, Umbertina Villano, Roberto Bruni, Anna R. Ciccaglione, Federica Frasca, Alessandra d’Auria, Ginevra Bugani, Gabriella d’Ettorre, Guido Antonelli, Carolina Scagnolari, Maddalena Fratelli, Lucia Gabriele”}]]

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Machine learning analysis of serum immune factors clustered SARS-CoV-2 patients into moderate (balanced-immune-modulation [BIM]) and severe groups; the latter composed of two distinct and opposite immune patterns (down-immune-modulation [DIM] and up-immune-modulation [UIM]). DIM/UIM and BIM clusters show different clinical, laboratory and immune parameters including T and B lymphocytes. ABSTRACT The complex pathophysiology of severe acute … Read more

Ex Vivo Modeling and Pharmacological Modulation of Tissue Immune Responses in Inflammatory Bowel Disease Using Precision‐Cut Intestinal Slices. [[{“value”:”Klaudia Maria Grieger, Valerie Schröder, Susann Dehmel, Vanessa Neuhaus, Dirk Schaudien, Maximillian Fuchs, Helena Linge, Alexander Wagner, Ulf Kulik, Benjamin Gundert, Heiko Aselmann, Armin Braun, Christina Hesse, Katherina Sewald”}]]

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Studying local immune responses in IBD remains challenging. This study demonstrates that precision-cut intestinal slices from IBD patients mimic key immunopathological features ex vivo and respond specifically to immune stimuli. This model allows direct pharmacological modulation of patient tissue ex vivo and offers a powerful platform for translational research. ABSTRACT Inflammatory bowel disease (IBD) affects … Read more

LAG3 Marks Activated but Hyporesponsive NK Cells. [[{“value”:”Valeria Vasilyeva, Olivia Makinson, Cynthia Chan, Maria Park, Colin O’Dwyer, Ayad Ali, Abrar Ul Haq Khan, Christiano Tanese de Souza, Mohamed S. Hasim, Sara Asif, Reem Kurdieh, John Abou‐Hamad, Edward Yakubovich, Jonathan Hodgins, Paul Al Haddad, Giuseppe Pietropaolo, Julija Mazej, Hobin Seo, Qiutong Huang, Sarah Nersesian, Damien Chay, Nicolas Jacquelot, David Cook, Seung‐Hwan Lee, Giuseppe Sciumè, Stephen Waggoner, Michele Ardolino, Marie Marotel”}]]

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NK cells quickly upregulate LAG3 upon activation. LAG3+ NK cells present hallmarks of immune exhaustion. The role of LAG3 in imposing NK cell dysfunction remains to be elucidated. ABSTRACT NK cells are critical for immunosurveillance, yet become dysfunctional when chronically stimulated by virally infected or cancerous cells. This phenomenon is similar to T cell exhaustion … Read more

Platelet‐Based Nanotechnology Improves Cancer Immunotherapy. [[{“value”:”Yanlin Lv, Guanghui Ma”}]]

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This review examines platelet-based nanotechnology in cancer immunotherapy, leveraging platelets’ innate properties via membrane-mimicking systems and engineered platelets to enhance targeting, immune responses, and efficacy, while outlining future directions for its applications in cancer treatment. ABSTRACT Cancer immunotherapy is a cornerstone of precision medicine, yet its efficacy is often hampered by the immunosuppressive and heterogeneous … Read more

Self‐Antigens Select B Cells: A New Perspective on B Cell Selection and Function. [[{“value”:”Mike Aoun, Rikard Holmdahl”}]]

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Positively selected autoreactive B cells (C1-Bsup) specific for collagen type II (COL2) suppress inflammation, while pathogenic COL2-specific plasma cells (CB20 clone) drive it. The balance between suppressive and pathogenic autoreactive responses governs tissue homeostasis. ABSTRACT The adaptive immune system is shaped by self-recognition, creating a paradox where autoreactivity is essential for immune regulation, yet implicated … Read more

Teriflunomide Inhibits Human FOXP3+ Regulatory T Cell Function by Interference With Mitochondrial Respiration. [[{“value”:”Aleksandra Dyczko, Beatriz F. Côrte‐Real, Ibrahim Hamad, Ralf A. Linker, Markus Kleinewietfeld”}]]

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Regulatory T cells rely on mitochondrial respiration to exert their anti-inflammatory functions and maintain immune homeostasis. Our study demonstrates that while teriflunomide inhibits effector T cells, it may also impair Treg metabolism and promote a dysfunctional, proinflammatory phenotype. Created in BioRender. Dyczko, A. (2025) https://BioRender.com/vl0s1vk ABSTRACT Regulatory FOXP3+ T cells (Tregs) have been characterized with … Read more

Homeobox Transcription Factor HOXB4 Distinctly Modulates Th2 and Th9 Cell Differentiation. [[{“value”:”Shagnik Chattopadhyay, Sayantee Hazra, Biswajit Biswas, Ritobrata Goswami”}]]

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Our study delineates the molecular mechanisms employed by HOXB4 in regulating both Th2 and Th9 cell differentiation. We show that HOXB4 differentially regulates the secretion of different signature cytokines like IL-9 in a cell-specific manner, either directly or indirectly influencing their promoters by binding partner proteins like PU.1. ABSTRACT CD4+ T helper cells are involved … Read more

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