European Journal of Immunology

Adapted Live SARS‐CoV‐2 Vaccine Elicits Rapid Mucosal Immunity, Protects From Disease, and Reduces Shedding of XBB.1.5. [[{“value”:”Jana Kochmann, Tobias Britzke, Nico Joël Halwe, Lorenz Ulrich, Angele Breithaupt, G. Tuba Barut, Nadine Ebert, Bettina Salome Trüeb, Volker Thiel, Anca Dorhoi, Martin Beer, Donata Hoffmann, Björn Corleis, Jacob Schön”}]]

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An attenuated live vaccine (OTS-300) expressing the XBB.1.5 Spike provided rapid and complete protection against homologous challenge in the hamster model, accompanied by fast systemic and mucosal antibody responses and markedly reduced transmission compared with XBB.1.5 mRNA vaccination. Therefore, vaccination with the OTS LAV platform may help to disrupt transmission chains. ABSTRACT The emergence of … Read more

Interferon‐Regulatory Factor 4 Is Required Not Only for Induction but Also for Maintenance of the Th17 Phenotype. [[{“value”:”Janis Patten, Prema Erramsetti, Addi Josua Romero Olmedo, Olaf Pinkenburg, Magdalena Huber, Michael Lohoff”}]]

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We previously showed that primary differentiation of naïve T cells is dependent on IRF4. Now we show that maintenance of already differentiated conventional and pathogenic Th17 cells is also dependent on IRF4.

ADAR1 Controls Macrophage Scavenging and Lipid‐Buffering Programs in Metabolic Tissues. [[{“value”:”Achilleas Fardellas, Emelie Barreby, Madara Brice, Sebastian Nock, Jules Russick, Ana Vankova, Charlotte Edberg, Ida Robertsen, Jens K. Hertel, Per Stål, Gunnar Mellgren, Cecilia Karlsson, Jøran S. Hjelmesaeth, Hannes Hagström, Erik Näslund, Volker M. Lauschke, Johan Fernø, Ping Chen, Cecilia Morgantini, Myriam Aouadi, Niklas K. Björkström”}]]

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ADAR1 expression increase during monocyte-to-macrophage differentiation via an alternative transcription start site. Isoform-specific ADAR1 activity governs key macrophage functions, including efferocytosis, endocytosis, lipid metabolism, and proliferation. Moreover, ADAR1 in macrophages responds to different metabolic states and buffers lipotoxicity under high metabolic load. Vectors obtained from https://BioRender.com. ABSTRACT Adenosine deaminase acting on RNA 1 (ADAR1) regulates … Read more

Human Blood IgA+ Memory B Cells Differ From IgG+ B Cells by Expressing Gut‐Homing and Regulatory Markers. [[{“value”:”Louise Le Gal, Léo Boussamet, Alexandra Garcia, Jérémy Morille, Emilie Dugast, Arnaud B. Nicot, David‐Axel Laplaud, Laureline Berthelot”}]]

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Compared with IgG+ and IgM+ memory B cells, IgA+ memory B cells displayed distinct phenotypical markers: PD-L1, GPR183, CCR9, CCR10, α4β7, CD11b. A particular transcriptomic signature, with RUNX2, ARHGEF10L, XYLT1, TRPS1, and CHL1 upregulation, characterized the IgA+ memory B cell population, whereas miR4432HG was a marker of IgG+ memory B cells. ABSTRACT IgA is the … Read more

Accumulation of Siglec10+CX3CR1+ Macrophages in the Tumor Microenvironment of Glioblastomas. [[{“value”:”Nico Andreas, Lucas Gath, Paul Mike Jordan, Saskia Steiner, Oliver Werz, Nazife Dinc, Peter Baumgarten, Christian Senft, The OncoSurgeJena Team, Falko Schwarz, Nazeer Aboud, Ramazan Dalkilic, Sergio A. Calero Martinez, Katharina Klumbies, Aaron Lawson McLean”}]]

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By comparing various brain tumors, we identified a CX3CR1+ Siglec10+ double-positive macrophage subpopulation specifically enriched in highly malignant Glioblastomas (GBMs), wherein they accumulated in metabolically active tumor areas. Thus, they potentially serve as a diagnostic indicator population for GBMs and as targets of future GBM-specific treatment strategies. ABSTRACT Glioblastoma (GBM) is one of the most … Read more

EXPRESSION OF CONCERN: Activation of Epstein‐Barr Virus/C3d Receptor (gp140, CR2, CD21) on Human Cell Surface Triggers pp60src and Akt‐GSK3 Activities Upstream and Downstream to PI 3‐Kinase, Respectively.

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ABSTRACT EXPRESSION OF CONCERN: M. Barel, M. Balbo, M. Le Romancer and R. Frade, “Activation of Epstein-Barr Virus/C3d Receptor (gp140, CR2, CD21) on Human Cell Surface Triggers pp60src and Akt-GSK3 Activities Upstream and Downstream to PI 3-Kinase, Respectively,” European Journal of Immunology 33, no. 9 (2003): 2557–2566, https://doi.org/10.1002/eji.200324059. This Expression of Concern is for the … Read more

Increased Constitutive Interferon‐β Levels and Altered CD4 T Cell Homeostasis Induced by Expression of a Viral Glycoprotein. [[{“value”:”Hanspeter Pircher, Oliver S. Thomas, Anne S. Haefke, Annette Oxenius, Thomas Boehm”}]]

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Constitutive interferon (IFN) production is regulated by microbiota and essential for optimal immune responses. Here, we demonstrate that expression of the glycoprotein of LCM virus upregulates constitutive IFN-β levels and IFN-stimulated genes (ISGs) in transgenic mice. Moreover, it increased self-antigen-driven memory-phenotype CD4 T cells and effector regulatory CD4 T cells. ABSTRACT Besides the strong Type … Read more

Uncovering Immune Niches in Health and Disease Using Spatial Transcriptomics. [[{“value”:”Johan Thorsson, Yang Zhao, Eduardo J. Villablanca, Camilla Engblom”}]]

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Through the lens of spatial transcriptomics and associated tools, novel immune niche constituents can now be resolved. Drawing on gut and tumor contexts, we propose a framework to define immune niches and integrate clonal dynamics, aiming to advance niche-directed therapies toward precise, context-specific immune modulation. ABSTRACT Spatial transcriptomics allows for the investigation of complex cellular … Read more

B‐Cell Differentiation of Human Hematopoietic Progenitors Is Efficiently Supported by Wharton Jelly‐Derived Mesenchymal Stem Cells. [[{“value”:”Louison Collet, Hakim Ouled‐Haddou, Hussein Ghamlouch, Walaa Darwiche, Cathy Gomila, Brigitte Gubler, Loïc Garcon, Delphine Lebon, Jean‐Pierre Marolleau”}]]

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Wharton’s jelly-derived mesenchymal stromal cells isolated from umbilical cord were used to recreate a human stromal environment for B-cell development in vitro. In co-culture, CD34+ hematopoietic progenitors from bone marrow or cord blood differentiated into mature IgM-expressing B cells by day 11, while the Nalm-16 B-ALL cell line showed rapid IgM expression as early as … Read more

Nicotine Suppresses Human Memory Th Cell Subsets With Preferential Effects on Central Memory Th Cells in an α7 Nicotinic Acetylcholine Receptor‐Dependent Manner. [[{“value”:”Fatemeh Gholizadeh, Mehri Hajiaghayi, Niloufar Rahbari, Jennifer S. Choi, Samantha Heidt, Alexia Como, Maryam Kazerouni, Melika Kargar, Aude Pinard‐LaRoche, Steve C. C. Shih, Peter J. Darlington”}]]

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Human memory Th cells were separated into Tcm (CD45RO+ CD62L+) and Tem (CD45RO+ CD62L−). Nicotine preferentially suppressed Th1-, Th2-, Th17-, and Tfh-associated programs in Tcm via an α7nAChR-dependent mechanism, with minimal effect in Tem. ABSTRACT Memory T helper (Th) cells sustain protective recall responses but can also drive chronic inflammation, necessitating precise regulation of their … Read more

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