European Journal of Immunology

An isolation protocol for plasma cells (PC) from the chicken Harderian gland (HG) was established, and analyses of PCs revealed a FSChigh/CD45med/sIgpos/CD57pos/CXCR4high/TACIlow phenotype. Presence of CXCL12 and BAFF around HG PCs suggests a contribution of CXCL12–CXCR4 and BAFF–TACI to PC localization and survival. ABSTRACT Due to fundamental differences in B cell development between birds and … Read more

We investigated differences in peptide repertoire when β2-microglobulin is fused to the HLA-I heavy chain. We observed: (1) that immunopeptidomes changed in this condition, (2) an overall increased median IC50 of the entire peptide repertoire, and (3) a reduced presentation of cancer-specific epitopes with a strong predicted binding affinity for HLA-I. ABSTRACT β2-Microglobulin (β2m) is … Read more

Our study reveals that STING activation in dendritic cells using cGAMP-VLP enhances CD8+ T cell recognition of live tumor cells by inducing type I interferon-dependent upregulation of MHC-I on tumor cells in vitro. In vivo, cGAMP-VLP boosts antitumor immunity even in cGAS-deficient tumors, thereby improving the efficacy of immune checkpoint blockade. These findings uncover a … Read more

High-dimensional imaging mass cytometry reveals diverse macrophage populations in human dorsal root ganglia (DRG). Microglia-like cells, characterized by markers such as P2RY12, SLC2A5, and TMEM119, localize near neuronal structures, whereas other myeloid subsets are found in interstitial regions. Spatial analysis reveals distinct localization patterns within the DRG. ABSTRACT The human dorsal root ganglia (DRG) are … Read more

This study shows that loss of sialylation in CT26 cells reduces peritoneal tumor burden, correlating with a lower peritoneal cancer index score. These tumors exhibited increased immune infiltration with prominent alterations in the myeloid compartment and immune cell correlations unique to desialylated tumors, indicating profound reshaping of antitumor immunity. ABSTRACT Colorectal cancer (CRC) patients are … Read more

YB-1 is essential for invariant NKT cell development, integrating TCR, co-stimulatory, and IL-15 signaling to control maturation, subset differentiation, and survival. Its loss at the double-positive thymocyte stage causes ∼80% iNKT cell depletion, maturation arrest, impaired cytokine production, and increased apoptosis. ABSTRACT Y-box binding protein 1 (YB-1) is a multifunctional RNA- and DNA-binding protein with … Read more

The A allele of the intronic SNP rs80262450 in the PTPN2 gene favors the expression of the splicing isoform PTPN2.4. This cytoplasmic isoform enhances TNF-α production in myeloid cells, thereby contributing to intestinal inflammation. These findings identify PTPN2.4 as a key pathogenic regulator and potential therapeutic target for inflammatory bowel disease. ABSTRACT Genome-wide association studies … Read more

Hypoxia activates the HIF complex (HIF-1α, HIF-1β, HIF-2α) to induce AID expression in B cells independently of cytokine signaling. However, hypoxia alone is insufficient to trigger class switch recombination (CSR), which additionally requires cytokine-driven chromatin accessibility, highlighting a mechanistic uncoupling between AID induction and functional antibody diversification. ABSTRACT Hypoxia has been shown to shape the … Read more

This study showed dysregulated αβ T cell homeostasis with ongoing T cell activation and low-grade inflammation in 5-12-year-old CHD children who underwent early-life cardiac surgery with thymectomy, characterized by reduced naïve T cells and increased memory/effector and senescent-like T cells. There was also higher expression of inhibitory receptors on effector T cells and elevated suppressive … Read more

Genetic and epidemiological studies have together identified hundreds of risk factors for MS, but we know relatively little about the mechanisms through which these cause disease. In this review, we explore a new generation of studies that are integrating genetics and environment to uncover disease mechanisms. Progress toward novel therapeutics is likely to come from … Read more