European Journal of Immunology

This review examines platelet-based nanotechnology in cancer immunotherapy, leveraging platelets’ innate properties via membrane-mimicking systems and engineered platelets to enhance targeting, immune responses, and efficacy, while outlining future directions for its applications in cancer treatment. ABSTRACT Cancer immunotherapy is a cornerstone of precision medicine, yet its efficacy is often hampered by the immunosuppressive and heterogeneous … Read more

Positively selected autoreactive B cells (C1-Bsup) specific for collagen type II (COL2) suppress inflammation, while pathogenic COL2-specific plasma cells (CB20 clone) drive it. The balance between suppressive and pathogenic autoreactive responses governs tissue homeostasis. ABSTRACT The adaptive immune system is shaped by self-recognition, creating a paradox where autoreactivity is essential for immune regulation, yet implicated … Read more

Regulatory T cells rely on mitochondrial respiration to exert their anti-inflammatory functions and maintain immune homeostasis. Our study demonstrates that while teriflunomide inhibits effector T cells, it may also impair Treg metabolism and promote a dysfunctional, proinflammatory phenotype. Created in BioRender. Dyczko, A. (2025) https://BioRender.com/vl0s1vk ABSTRACT Regulatory FOXP3+ T cells (Tregs) have been characterized with … Read more

Our study delineates the molecular mechanisms employed by HOXB4 in regulating both Th2 and Th9 cell differentiation. We show that HOXB4 differentially regulates the secretion of different signature cytokines like IL-9 in a cell-specific manner, either directly or indirectly influencing their promoters by binding partner proteins like PU.1. ABSTRACT CD4+ T helper cells are involved … Read more

Chronic mucocutaneous candidiasis can be caused by an Inborn Error of Immunity, especially those affecting TH-17 / IL-17 responses. Through in-depth immunophenotyping and functional assays, we reveal the association between homozygous carriage of the common p.R381Q IL-23R genetic variant and increased candidiasis susceptibility, relying on disrupted IL-23-mediated IL-17 immunity.

Biomarkers of vascular integrity and inflammatory processes are involved in different types of angioedema, highlighting the potential importance of complement/lectin system interactions with granulocytes in understanding angioedema triggers. The C1s/C1-INHc-to-MASP-1/C1-INHc ratio could be used as a diagnostic tool to distinguish C1-INH-HAE from other HAE subtypes. ABSTRACT The precise molecular mechanisms underlying angioedema attacks in cases … Read more

Mycobacterium tuberculosis infection of human monocyte-derived macrophages during febrile conditions significantly induces heat shock protein-70 (HSP70) expression, which modulates cytokine responses. This highlights that pathophysiological responses, such as fever, regulate tuberculosis immunopathology. ABSTRACT Fever is a common clinical symptom in patients with tuberculosis (TB). During fever, heat-shock proteins (HSPs), such as HSP70, are expressed, which … Read more

The Sialic acid/Siglec axis is emerging as an important target in the TME. We explore the role of sialylation within stromal-rich, immunosuppressive TMEs, focusing on how specific sialic acid/Siglec interactions dictate innate and adaptive immune responses. We propose that targeting glycoimmune checkpoints as a mechanism may overcome stromal-mediated therapy resistance and enhance anti-tumour immunity. ABSTRACT The … Read more

The T cell response induced by SARS-CoV-2 vaccines is an essential component of immune protection against COVID-19. Multiparametric flow cytometry analysis emerges as a valuable tool for in-depth assessment of T cell phenotype nuances that occur after booster vaccination, such as a fifth dose of an inactivated SARS-CoV-2 vaccine. Figure created with BioRender.com.

Innate lymphoid cells contribute to the health of the uterine microenvironment, which is important for global health. Endometriosis affects 10% of women of fertile age. Millions of pregnancies have adverse outcomes every year: miscarriages, pre-eclampsia, fetal growth restriction, preterm labour and stillbirth — all due to defective placentation. Abnormal fetal growth exposes newborns to greater … Read more