Journal for ImmunoTherapy of Cancer – Page 10

Intratumoral TIGIT blockade augments antitumor responses and bypasses increased functionality of peripheral TIGIT+ NK cells in mouse and human models of bone and soft tissue sarcoma

22 de July de 2026 by

Background
TIGIT (T cell immunoreceptor with Ig and ITIM domains) has emerged as a key exhaustion marker of intratumoral natural killer (NK) cells, but results from clinical trials with TIGIT blockade have been largely negative. Recent data have sugge…

Therapy-induced senescence rewires the melanoma secretome to promote antitumor immune response and augment cell therapies

22 de July de 2026 by

Background
Therapy-induced senescence (TIS) is a common outcome of diverse anticancer treatments, including chemotherapy, radiation, and small-molecule inhibitors. Senescence is characterized by stable growth arrest and the senescence-associated secre…

Decoding neoantigen-encoding tumor-specific transcripts unveils a shared target reservoir for immunotherapy in hepatocellular carcinoma

21 de July de 2026 by Lin, P., Wen, Y., Zhao, J., Zhang, F., Su, Y., He, H., Yu, H., Li, Q., Liu, C., Hu, Z., Li, Y., Fang, Z., Liang, L., Huang, S.

Background
Primary liver cancer, predominantly hepatocellular carcinoma (HCC), has limited therapeutic options. While mutation-derived neoantigen vaccine holds promise, its success is hindered by low antigen availability. This study explores transcrip…

Intratumoral Capnocytophaga leadbetteri promotes cancer cells proliferation and recruits neutrophils by activating TLR4/MyD88/NF-{kappa}B axis in oral squamous cell carcinoma

21 de July de 2026 by

Background
Intratumoral bacteria influence the progression and treatment response of solid tumors through multiple mechanisms. Oral squamous cell carcinoma (OSCC) is a common malignant tumor in the head and neck; however, the role of intratumoral bact…

Safety and efficacy of fecal microbiota transplantation in solid cancers resistant to immune checkpoint inhibitors: results of the MITRIC trial

20 de July de 2026 by Ullern, A., Garborg, K. K., Chauhan, S. K., Holm, K., Bang, C., Dunn, C., Johnsen, P. H., Hov, J. E. R., Kyte, J. A.

Background
Fecal microbiota transplantation (FMT) has shown promise in overcoming resistance to immune checkpoint inhibitors (ICIs) in early-phase cancer trials. We investigated the safety, feasibility and efficacy of FMT from ICI responders to patien…

Phase 1/2 study of IMC-C103C, a T cell receptor bispecific (MAGE-A4xCD3) ImmTAC targeting MAGE-A4-expressing malignancies

20 de July de 2026 by

Purpose
IMC-C103C is an ImmTAC bispecific (MAGE-A4xCD3) T cell engager targeting a peptide from the cancer-testis antigen MAGE-A4 presented by HLA-A*02:01. This phase 1/2 study in advanced solid tumors (IMC-C103C-101; NCT03973333) investigated the saf…

Frontline immunotherapy with response-guided subsequent treatment (FIRST) in cutaneous squamous cell carcinoma: a Bayesian causal analysis of dose intensity, early benefit, and treatment de-escalation

20 de July de 2026 by

Background
Programmed death receptor 1 (PD-1) blockade produces high response rates in resectable and locally advanced cutaneous squamous cell carcinoma (CSCC), but how many doses are needed and whether surgery or radiation after immunotherapy (consol…

Spatial architecture of tertiary lymphoid structures represents an independent prognostic dimension in hepatocellular carcinoma

17 de July de 2026 by Liu, W., Zhu, C., Cui, Z., Shi, J., Zhang, B., Xiong, A., Wang, L., Gao, Q., Ding, G., Liu, X.

Background and aims
Tertiary lymphoid structures (TLS) are associated with heterogeneous outcomes in hepatocellular carcinoma (HCC), but whether their anatomical context determines clinical impact remains unknown. We hypothesized that spatial compartm…

RAS signaling at the crossroads of radioresistance and tumor immunity

17 de July de 2026 by

RAS mutations are among the most prevalent oncogenic drivers in solid tumors and are consistently associated with suboptimal responses to radiation therapy (RT). Within this family, KRAS is the dominant isoform and a central regulator of tumor stress …

Blautia coccoides-derived acetate potentiates anti-PD-1 immunotherapy in melanoma by activating cytotoxic CD8+ T cells

16 de July de 2026 by Zhang, Z., Liang, X., Tian, Y., Li, C., Cao, X., Wang, D., Xie, A., Liu, S., Lin, K., Li, Q., Liang, Y.

Background
Gut microbiota can modulate cancer immunotherapy and enhance the efficacy of programmed cell death protein 1 (PD-1) blockade in tumors, yet the responsible microbes and underlying mechanisms remain incompletely understood.

Methods
Publicly…