Journal of Leukocyte Biology

Immunoregulatory Functions of the ER Stress Sensor IRE1 in Myeloid Cell Biology​Alonso Lira on 18 de October de 2025 at 10:00

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J Leukoc Biol. 2025 Oct 17:qiaf145. doi: 10.1093/jleuko/qiaf145. Online ahead of print. ABSTRACT Myeloid cells- including monocytes, macrophages, dendritic cells (DCs), and granulocytes constitute a versatile arm of the immune system, serving as frontline sentinels that detect and react to environmental cues and orchestrate tailored immune responses. Their ability to respond promptly to distinct threats … Read more

The Regulatory Effects of Hypoxic Environment on Neutrophil Function and the Related Molecular Mechanisms​Yun-Chen Zhu on 15 de October de 2025 at 10:00

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J Leukoc Biol. 2025 Oct 14:qiaf144. doi: 10.1093/jleuko/qiaf144. Online ahead of print. ABSTRACT Metabolic remodeling is involved in multiple diseases, including tumors, acute and chronic inflammations, but our understanding of the molecular pathways remains limited. Neutrophils, as pivotal effector cells of the innate immune system, exhibit significant functional heterogeneity influenced by the hypoxic microenvironment, a … Read more

CircNR3C1 Promotes Acute Lymphoblastic Leukemia Progression via the MSI2/ENO1/RPS3 Axis​Ping Lei on 10 de October de 2025 at 10:00

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J Leukoc Biol. 2025 Oct 10:qiaf139. doi: 10.1093/jleuko/qiaf139. Online ahead of print. ABSTRACT Acute lymphoblastic leukemia (ALL) is a hematological malignancy characterized by the uncontrolled proliferation of immature lymphoid cells, but the role of circNR3C1 in ALL is not fully elucidated. In this study, expression levels of circNR3C1, RPS3, ENO1, and MSI2 were assessed in … Read more

Tregitopes derived from canine proteins can enhance T regulatory lymphocytes frequency in dog PBMC culture in vitro​Paweł Szydłowski on 9 de October de 2025 at 10:00

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J Leukoc Biol. 2025 Oct 10:qiaf143. doi: 10.1093/jleuko/qiaf143. Online ahead of print. ABSTRACT Adoptive cell therapy using ex vivo expanded autologous Tregs could be a novel therapeutic approach for cell-based immunotherapy in dogs. This study aimed to expand dog Treg lymphocytes via the use of tregitopes. PBMCs were isolated from healthy beagle dogs and stimulated … Read more

Actin regulation of neutrophil effector mechanisms in health and disease​Noelle Pisacano on 9 de October de 2025 at 10:00

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J Leukoc Biol. 2025 Oct 9:qiaf142. doi: 10.1093/jleuko/qiaf142. Online ahead of print. ABSTRACT Neutrophils are central to immune responses in health and disease, and their ability to deform correlates with their functional responses. In health, reorganisation of the neutrophil cytoskeleton allows neutrophils to carry out their effector mechanisms. However, in the disease state, dysregulation of … Read more

Human CD24+CD38+ regulatory B cells promote Pro-resolving Macrophage Function through the synergistic effect of IL-10 and PD-L1​Elaheh Dalir Abdolahinia on 8 de October de 2025 at 10:00

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J Leukoc Biol. 2025 Oct 7:qiaf141. doi: 10.1093/jleuko/qiaf141. Online ahead of print. ABSTRACT Regulatory B cells (Bregs), specifically the CD24⁺CD38⁺ phenotype, are known for their capacity to reduce inflammation by releasing interleukin 10(IL-10). However, their potential role in regulating inflammation through macrophage differentiation is not well understood. This study investigates how CD24⁺CD38⁺ regulatory B cells … Read more

Lyn expression in macrophages promotes TLR activation and restricts proliferation in an isoform-independent manner​Anders J Lindstedt on 7 de October de 2025 at 10:00

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J Leukoc Biol. 2025 Oct 7:qiaf140. doi: 10.1093/jleuko/qiaf140. Online ahead of print. ABSTRACT Toll-like receptor (TLR) signaling is vital for antimicrobial macrophage function, and its dysregulation is associated with diseases such as lupus, multiple sclerosis, pulmonary fibrosis, and cancer. The Src-family kinase Lyn may have net activating or inhibitory effects on TLR signaling, yet distinct … Read more

Transient alterations in nucleosome distribution and sensitivity to nuclease define the THP-1 monocyte-to-macrophage transition​Jane M Benoit on 1 de October de 2025 at 10:00

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J Leukoc Biol. 2025 Oct 1;117(10):qiaf062. doi: 10.1093/jleuko/qiaf062. ABSTRACT The monocyte-to-macrophage transition is marked by alterations to both the structure and function of the genome, including changes in histone posttranslational modifications, DNA methylation, 3D nuclear architecture, and expression of lineage specific genes. The nucleosome is the fundamental organizational unit of the eukaryotic genome and underpins … Read more

Dynamic nucleosome redistribution and increases in nucleosome sensitivity underpin THP-1 macrophage response to LPS​Jane M Benoit on 1 de October de 2025 at 10:00

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J Leukoc Biol. 2025 Oct 1;117(10):qiaf067. doi: 10.1093/jleuko/qiaf067. ABSTRACT Macrophages detect lipopolysaccharide (LPS) through toll-like receptor 4 (TLR-4) on the cell surface which initiates a signaling cascade, resulting in the recruitment of regulatory factors to chromatin and subsequent expression of chemokine and cytokine genes. Primary response genes, marked by poised promoters and enhancers, are rapidly … Read more

Tissue damage, myocardial injury and recruitment of mature and banded neutrophils after high-intensity endurance exercise​Bernard N Jukema on 30 de September de 2025 at 10:00

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J Leukoc Biol. 2025 Sep 30:qiaf137. doi: 10.1093/jleuko/qiaf137. Online ahead of print. ABSTRACT Neutrophils are key players in inflammatory responses that are modulated by cytokines/chemokines and damage associated molecular patterns (DAMPs). Exercise induces acute neutrophilia, but little is known regarding recruitment of neutrophil subsets (banded (CD16dim/CD62Lbright) and hypersegmented (CD16bright/CD62Ldim) cells) and it’s relation with the … Read more

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