Journal of Leukocyte Biology

J Leukoc Biol. 2025 Aug 29:qiaf123. doi: 10.1093/jleuko/qiaf123. Online ahead of print. ABSTRACT Trained immunity amplifies innate immune responses in an antigen-independent manner. This study explored the ability of trained human primary macrophages to modulate the phenotype and function of T cells. Macrophages play an important role in antigen presentation, resulting in T-cell activation and … Read more

J Leukoc Biol. 2025 Aug 5;117(8):qiaf115. doi: 10.1093/jleuko/qiaf115. ABSTRACT We present a novel classification system for murine thymic epithelial cells (TECs), identifying 11 distinct types, four in the thymic cortex and seven in the medulla, based on their spatial localization and unique ultrastructural features. As key stromal components of the thymic microenvironment, TECs play indispensable … Read more

J Leukoc Biol. 2025 Aug 5;117(8):qiaf112. doi: 10.1093/jleuko/qiaf112. ABSTRACT Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in preterm infants and is a major health hazard for preterm infants worldwide. Hyperoxia-induced oxidative stress is one of the major risk factors for the development of BPD, and ideas for timely intervention in the development … Read more

J Leukoc Biol. 2025 Aug 5;117(8):qiaf084. doi: 10.1093/jleuko/qiaf084. ABSTRACT Tumor heterogeneity and the complex immune microenvironment make it challenging to identify candidates for immunotherapy using dominant biomarkers. Tumor-infiltrating CD8+T cells, particularly CD103+CD8+ tissue-resident T cells and their specific subsets, are generally linked to better outcomes in many cancers, but their role in renal cancer remains … Read more

J Leukoc Biol. 2025 Aug 21:qiaf122. doi: 10.1093/jleuko/qiaf122. Online ahead of print. ABSTRACT The insulin-like growth factor (IGF) axis is crucial for regulating cell growth, survival, and differentiation. While therapies targeting the IGF-1 receptor (IGF-1R) have shown limited clinical success as single agents, the abnormal expression of its ligands, IGF-I and IGF-II, has been shown … Read more

J Leukoc Biol. 2025 Aug 16:qiaf121. doi: 10.1093/jleuko/qiaf121. Online ahead of print. ABSTRACT Severe trauma releases damage-associated molecular patterns (DAMPs), which activate the immune system via pattern recognition receptors. This triggers inflammatory cascades that can lead to systemic inflammatory response syndrome, immunosuppression, and multiple organ dysfunction syndrome. Pyroptosis is an inflammatory form of cell death … Read more

J Leukoc Biol. 2025 Aug 14:qiaf120. doi: 10.1093/jleuko/qiaf120. Online ahead of print. ABSTRACT Existing studies examining the relationships among immunological cell phenotype, plasma metabolites, and pancreatic cancer susceptibility are limited. More comprehensive research is required to elucidate the complex interactions underlying these associations. Genetic instruments for 731 immune phenotypes (N = 3,757), 1,400 circulating metabolites … Read more

J Leukoc Biol. 2025 Aug 11:qiaf119. doi: 10.1093/jleuko/qiaf119. Online ahead of print. ABSTRACT Platelets release microvesicles (PMVs) into the extracellular milieu upon activation. PMVs retain various platelet components, including functional mitochondria, and actively participate in intercellular communication with immune cells such as polymorphonuclear leukocytes (PMN). PMVs have been known to modulate the inflammatory response of … Read more

J Leukoc Biol. 2025 Aug 12:qiaf116. doi: 10.1093/jleuko/qiaf116. Online ahead of print. ABSTRACT Inflammatory bowel disease (IBD) is a debilitating and symptomatic disorder of the gastrointestinal tract, featuring dysregulated inflammation, intestinal injury and barrier dysfunction. IBD is also a risk factor for colorectal cancer (CRC), which remains a leading cause of cancer-related mortalities worldwide. Matrix … Read more

J Leukoc Biol. 2025 Aug 7:qiaf118. doi: 10.1093/jleuko/qiaf118. Online ahead of print. ABSTRACT Pediatric sepsis has constantly increased over the world, and is now a leading cause of children morbidity and mortality. Due to this alarming trend, intense research has been sparked into the unique characteristics of pediatric sepsis, the mechanisms behind the immune dysfunction, … Read more