Journal of Leukocyte Biology

Depression-like behavior is associated with changes in the meningeal lymphatic vasculature and meningeal B cells in a murine lupus model​Alexandra Olate-Briones on 25 de April de 2025 at 10:00

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J Leukoc Biol. 2025 Apr 23;117(4):qiaf016. doi: 10.1093/jleuko/qiaf016. ABSTRACT Meningeal lymphatic vasculature (mLV) comprises a network of vessels responsible for draining immune cells and fluid from the central nervous system (CNS) into the deep cervical lymph nodes. While changes in mLV function have been implicated in several neurodegenerative disorders, its role in autoimmune diseases is … Read more

Protective function of ex vivo-expanded CD8 T cells in a mouse model of adoptive therapy for cytomegalovirus infection depends on integrin beta 1 but not CXCR3, CTLA4, or PD-1 expression​Xiaokun Liu on 25 de April de 2025 at 10:00

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J Leukoc Biol. 2025 Apr 23;117(4):qiae256. doi: 10.1093/jleuko/qiae256. ABSTRACT The adoptive transfer of virus-specific T cells (VSTs) represents a therapeutic option for viral infection treatment in immunocompromised patients. Before administration, ex vivo culture enables VST expansion. However, it is unclear how ex vivo expansion affects the circulation, homing, and intra-tissue migration of administered VSTs. We … Read more

Different behavior of NK cells isolated from healthy women and women with recurrent spontaneous abortion after treatment with human amniotic epithelial cells​Fatemeh Rezayat on 25 de April de 2025 at 10:00

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J Leukoc Biol. 2025 Apr 23;117(4):qiaf020. doi: 10.1093/jleuko/qiaf020. ABSTRACT Maternal immunotolerance during pregnancy is heavily dependent on the critical properties of human amniotic epithelial cells (hAECs). Recurrent spontaneous abortion (RSA) is one of the most common diseases in women and is caused by feto-maternal immunotolerance disruption. The objective of this study is to investigate how … Read more

Regulation and therapeutic potential of NLRP3 inflammasome in intestinal diseases​Wenxue Li on 25 de April de 2025 at 10:00

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J Leukoc Biol. 2025 Apr 23;117(4):qiaf014. doi: 10.1093/jleuko/qiaf014. ABSTRACT The NOD-like receptor family, particularly the protein 3 that contains the pyrin domain (NLRP3), is an intracellular sensing protein complex responsible for detecting patterns associated with pathogens and injuries. NLRP3 plays a crucial role in the innate immune response. Currently, a wide range of research has … Read more

The release of NETs during SFTSV infection downregulates the specific inflammatory factors that lead to liver and spleen damage​Xuewen Ji on 25 de April de 2025 at 10:00

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J Leukoc Biol. 2025 Apr 25:qiaf053. doi: 10.1093/jleuko/qiaf053. Online ahead of print. ABSTRACT Severe fever with thrombocytopenia syndrome is a life-threatening condition that has been the focus of attention in recent years. It is primarily caused by uncontrolled replication of a novel Bunyavirus and an intense pro-inflammatory response. NETosis is a form of cell death … Read more

Presence of LILRB4 SNP rs1048801 modulates Acute Myeloid Leukemia progression and inhibits CD4+ T cells proliferation​Zhiyong Zhou on 25 de April de 2025 at 10:00

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J Leukoc Biol. 2025 Apr 25:qiaf052. doi: 10.1093/jleuko/qiaf052. Online ahead of print. ABSTRACT Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4), an emerging immune checkpoint molecule, exhibits therapeutic potential in acute myeloid leukemia (AML). While single nucleotide polymorphisms (SNPs) of immune checkpoint genes have been extensively investigated in AML, the association between LILRB4 genetic polymorphisms … Read more

What’s Atypical about Human B cells after Allogeneic Stem Cell Transplantation?​Sonali J Bracken on 24 de April de 2025 at 10:00

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J Leukoc Biol. 2025 Apr 24:qiaf048. doi: 10.1093/jleuko/qiaf048. Online ahead of print. ABSTRACT Atypical B cells or age-associated B cells (ABCs) represent an alternative lineage of memory B cells. Emerging evidence suggests that context influences the apparent functional heterogeneity of ABCs. While data support a protective role for ABCs in the setting of infection, multiple … Read more

No-lyse No-wash flow cytometry method for ex vivo study of human neutrophils​Y-S Tsai on 23 de April de 2025 at 10:00

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J Leukoc Biol. 2025 Apr 23:qiaf050. doi: 10.1093/jleuko/qiaf050. Online ahead of print. ABSTRACT Neutrophils are vital immune cells involved in immunity via their effector roles and death. While their rapid response to the environment is crucial for immune function, it also makes them difficult to study. Here, we provide a no-lyse no-wash (NLNW) flow cytometry … Read more

Deep phenotyping of human neutrophils in whole blood using a 33-color spectral flow cytometry panel​Vanessa Krémer on 17 de April de 2025 at 10:00

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J Leukoc Biol. 2025 Apr 17:qiaf049. doi: 10.1093/jleuko/qiaf049. Online ahead of print. ABSTRACT Neutrophils are the most abundant leukocytes in the circulation and critical players in host defense and inflammation. They respond rapidly to numerous biological, chemical, and physical stimuli, making it challenging to characterize their steady-state phenotypes, activation states, and subsets in an unbiased … Read more

UDP-glucose Regulates Dendritic Cell Mitochondrial Respiration via a Nitric Oxide-Dependent Mechanism​Bay Vagher on 17 de April de 2025 at 10:00

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J Leukoc Biol. 2025 Apr 17:qiaf047. doi: 10.1093/jleuko/qiaf047. Online ahead of print. ABSTRACT Bone marrow-derived dendritic cell (BMDC) activation is associated with rewiring of cellular metabolism and concurrent large-scale changes in gene expression promoting a pro-inflammatory program characterized by expression of inducible nitric oxide synthase (iNOS) and the production of nitric oxide (NO). NO inhibits … Read more

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