Journal of Leukocyte Biology

J Leukoc Biol. 2025 Dec 6:qiaf177. doi: 10.1093/jleuko/qiaf177. Online ahead of print. ABSTRACT Mucosal-associated invariant T (MAIT) cells are unique unconventional T cells with diverse roles in immunity, yet how their context informs their function is not well known. This contextual regulation is particularly relevant in cancer, where MAIT cells have an enigmatic role. We … Read more

J Leukoc Biol. 2025 Dec 5:qiaf171. doi: 10.1093/jleuko/qiaf171. Online ahead of print. ABSTRACT Eosinophils (EOS), named after the Greek dawn goddess Eos, are multifunctional granulocytes with roles surpassing their well-established involvement in allergic diseases and parasitic infections. Herein, we highlighted the recent advancements in understanding the cellular structure, lineage development, surface receptors, and diverse phenotypes … Read more

J Leukoc Biol. 2025 Dec 5:qiaf176. doi: 10.1093/jleuko/qiaf176. Online ahead of print. ABSTRACT Tumor-associated macrophages (TAM) exert both pro- and anti-tumoral functions that influence cancer progression and patient prognosis. However, single-cell RNA sequencing (scRNA-seq) studies have revealed that TAM heterogeneity remains incompletely characterized. By performing an unbiased, integrated in silico analyses of publicly available scRNA-seq … Read more

J Leukoc Biol. 2025 Dec 3:qiaf173. doi: 10.1093/jleuko/qiaf173. Online ahead of print. ABSTRACT Extracellular vesicles (EVs) are essential components for intercellular communication, bioactive cargo trafficking, and homeostasis maintenance. The knowledge regarding the diverse functions and applications of EVs has continually expanded over the recent decade. The classification of eukaryotic EVs based on their biophysical or … Read more

J Leukoc Biol. 2025 Nov 29:qiaf170. doi: 10.1093/jleuko/qiaf170. Online ahead of print. ABSTRACT Macrophage migration inhibitory factor (MIF) is broadly produced by various cell types, particularly immune cells, and functions as a key modulator of innate and adaptive immunity. Increasing evidence has linked MIF to the pathogenesis of both solid tumors and hematologic malignancies, including … Read more

J Leukoc Biol. 2025 Nov 28:qiaf168. doi: 10.1093/jleuko/qiaf168. Online ahead of print. ABSTRACT Monocytes play a fundamental role in the inflammatory response to diverse stimuli. A critical early step in the initiation of this response is the recruitment of monocytes from the bloodstream to sites of tissue injury. This migration is tightly regulated at the … Read more

J Leukoc Biol. 2025 Nov 4;117(11):qiaf149. doi: 10.1093/jleuko/qiaf149. NO ABSTRACT PMID:41296542 | DOI:10.1093/jleuko/qiaf149

J Leukoc Biol. 2025 Nov 4;117(11):qiaf152. doi: 10.1093/jleuko/qiaf152. ABSTRACT Sepsis is a life-threatening condition driven by a dysregulated host response to infection, in which the innate immune axis-particularly the crosstalk between neutrophils and macrophages-plays a central role in dictating disease trajectory. This review delineates the functional, metabolic, and spatial characteristics of these two phagocytic cell … Read more

J Leukoc Biol. 2025 Nov 20:qiaf167. doi: 10.1093/jleuko/qiaf167. Online ahead of print. ABSTRACT IRGM proteins are associated with increased susceptibility to Crohn’s disease, mycobacterial infections, sepsis, and other inflammatory diseases, but the cells in which they function in vivo have not been delineated. To address this, mice with conditional deletions of Irgm1 were created and … Read more

J Leukoc Biol. 2025 Nov 4;117(11):qiaf138. doi: 10.1093/jleuko/qiaf138. ABSTRACT Natural killer (NK) cells are the first line of defense against viral infections and tumors. Their cytotoxic activity relies on the formation of an immune synapse (IS) with target cells. The lymphocyte function-associated antigen (LFA)-1 plays a central role in NK cell cytotoxicity by modulating NK-IS … Read more