Journal of Leukocyte Biology

J Leukoc Biol. 2026 Jan 14:qiag009. doi: 10.1093/jleuko/qiag009. Online ahead of print. ABSTRACT Eosinophils are a type of white blood cell belonging to the granulocyte family. Their cytoplasm contains eosinophilic granules that hold various biologically active substances. They perform diverse functions, participating in inflammatory responses, immune defense, and tissue repair. Eosinophils are implicated in the … Read more

J Leukoc Biol. 2026 Jan 10:qiag005. doi: 10.1093/jleuko/qiag005. Online ahead of print. ABSTRACT Emerging evidence demonstrates that innate immune cells can maintain a non-specific memory, not only in response to microbe-associated ligands such as β-glucan, but also synthetic biomaterials and nano- and microparticles. This creates an opportunity to leverage biomaterials which can establish favourable innate … Read more

J Leukoc Biol. 2026 Jan 8:qiag003. doi: 10.1093/jleuko/qiag003. Online ahead of print. ABSTRACT Prior studies have demonstrated associations between eosinophil activation products and incident stroke. We investigated whether circulating eosinophil concentration is associated with imaging markers of atherosclerotic cardiovascular disease (ASCVD), analyzing two arterial beds (carotid artery plaque [CAP] and coronary artery calcium [CAC]) in … Read more

J Leukoc Biol. 2026 Jan 8:qiag007. doi: 10.1093/jleuko/qiag007. Online ahead of print. ABSTRACT Bazedoxifene is a selective estrogen receptor modulator that is prescribed to menopausal women to treat symptoms of estrogen deficiency. Furthermore, bazedoxifene is being considered for cancer therapeutics due to its ability to block IL-6 signaling. However, various selective estrogen receptor modulators have … Read more

J Leukoc Biol. 2026 Jan 5:qiaf189. doi: 10.1093/jleuko/qiaf189. Online ahead of print. ABSTRACT CD101 is a disulfide-linked immunoglobulin-like glycoprotein with a unique glutamine-tryptophan-isoleucine (EWI) sequence motif. Allelic variations within the Cd101 gene can influence CD101 expression and function of different myeloid cell and T lymphocyte populations. CD101 serves also as maturation marker for neutrophils and … Read more

J Leukoc Biol. 2026 Jan 5:qiag001. doi: 10.1093/jleuko/qiag001. Online ahead of print. ABSTRACT IKZF3/Aiolos is a zinc-finger transcriptional transcription factor that functions as a transcriptional repressor in B cell development. IKZF3 mutations are associated with human diseases including immunodeficiency, leukemia and lymphoma. H195Y IKZF3 mutation was discovered in a mouse model of precursor B cell … Read more

J Leukoc Biol. 2026 Jan 5:qiag002. doi: 10.1093/jleuko/qiag002. Online ahead of print. ABSTRACT Tumor necrosis factor-α (TNF) and its receptors have emerged as key players in autoimmunity but also influence tumor development and the tumor microenvironment in many ways. TNF-inhibiting biologics are used very successfully in the clinic to treat autoimmune diseases. However, in some … Read more

J Leukoc Biol. 2026 Jan 2:qiaf188. doi: 10.1093/jleuko/qiaf188. Online ahead of print. ABSTRACT Changes in specific immune cell lineages, such as T and B cells, play a central role in the pathogenesis of rheumatoid arthritis (RA). However, a comprehensive evaluation of systemic immune cell changes in RA remains limited. Immune cell proportions of 104 subsets … Read more

J Leukoc Biol. 2025 Dec 26;118(1):qiaf169. doi: 10.1093/jleuko/qiaf169. ABSTRACT Severe burns complicated by acute lung injury are critical causes of respiratory failure and multiple organ dysfunction syndrome. Neutrophils extensively infiltrate lung tissues early postburn to mediate pulmonary damage, but the underlying mechanisms remain unclear. We analyzed gut microbiota of severe burn patients via metagenomics and … Read more

J Leukoc Biol. 2025 Dec 30:qiaf187. doi: 10.1093/jleuko/qiaf187. Online ahead of print. ABSTRACT Cholesterol metabolism plays a pivotal role in gastrointestinal (GI) cancers, from fuelling tumor growth, facilitating metastatic niche formation, shaping tumor immunosuppressive microenvironment to promoting immunotherapy resistance. Paradoxically, cholesterol may also exert context-dependent protective effects. Statins, the most widely prescribed cholesterol-lowering drugs, function … Read more