Journal of Leukocyte Biology

J Leukoc Biol. 2024 Nov 4:qiae242. doi: 10.1093/jleuko/qiae242. Online ahead of print. ABSTRACT Piezo1 is a mechanosensitive, nonselective Ca2+ channel which is broadly expressed in CD4+ T cells. Using lineage-specific Piezo1 knockout mice (Piezo1cKO), we show that loss of Piezo1 in CD4+ T cells significantly increased IFNγ and IL-17 production in vitro under TH1 and … Read more

J Leukoc Biol. 2024 Oct 29:qiae234. doi: 10.1093/jleuko/qiae234. Online ahead of print. NO ABSTRACT PMID:39471419 | DOI:10.1093/jleuko/qiae234

J Leukoc Biol. 2024 Oct 26:qiae235. doi: 10.1093/jleuko/qiae235. Online ahead of print. ABSTRACT Neutrophil extracellular traps (NETs) are promising promoters in venous thromboembolism (VTE). In the present study, we have investigated the potential thrombogenic role of NETs in colorectal cancer (CRC). A total of 583 patients with gastrointestinal malignancies who were diagnosed with or without … Read more

J Leukoc Biol. 2024 Oct 25:qiae227. doi: 10.1093/jleuko/qiae227. Online ahead of print. ABSTRACT Natural Killer (NK) cells are critical innate immune cells involved in the clearance of virally infected and malignant cells. Human NK cells are distinguished by their surface expression of CD56 and a lack of CD3. While CD56 expression and cell surface density … Read more

J Leukoc Biol. 2024 Oct 24:qiae232. doi: 10.1093/jleuko/qiae232. Online ahead of print. ABSTRACT Blood and airway eosinophilia represent markers for the endotype-driven treatment of allergic asthma. Little is known on mechanisms that link eosinophils and airway epithelial cells before and after these cells are infiltrated by eosinophils during allergic response. Given that innate immune mechanisms, … Read more

J Leukoc Biol. 2024 Oct 24:qiae237. doi: 10.1093/jleuko/qiae237. Online ahead of print. ABSTRACT The role of MIR654 in Burkitt’s lymphoma (BL) and whether it impacts expression of MYC, and its downstream activated MIR9 is not known. Expression of MYC, MYCN, MYCL, MIR9/3P, MIR654/5P, and MIR654/3P were assessed by qRT-PCR in biopsy samples from Epstein-Barr virus … Read more

J Leukoc Biol. 2024 Oct 24:qiae236. doi: 10.1093/jleuko/qiae236. Online ahead of print. ABSTRACT Rheumatoid arthritis is a common autoimmune disease, but little is known about the characteristics of the B cell repertoires in the peripheral blood. In this study, the peripheral IgM repertoires of early rheumatoid arthritis (ERA) patients were analyzed by high-throughput sequencing and … Read more

J Leukoc Biol. 2024 Oct 22:qiae231. doi: 10.1093/jleuko/qiae231. Online ahead of print. ABSTRACT The impact of aging on T cell subsets, specifically CD4+ and CD8+ T cells, leading to immune system dysfunction, has been the focus of scientific investigation due to its potential to reverse age-associated deterioration. Transcriptomic and epigenomic studies have identified the primary … Read more

J Leukoc Biol. 2024 Oct 21:qiae223. doi: 10.1093/jleuko/qiae223. Online ahead of print. ABSTRACT Although the SARS-CoV-2 infection has established risk groups, identifying biomarkers for disease outcomes is still crucial to stratify patient risk and enhance clinical management. Optimal efficacy of COVID-19 antiviral medications relies on early administration within the initial five days of symptoms, assisting … Read more

J Leukoc Biol. 2024 Oct 21:qiae233. doi: 10.1093/jleuko/qiae233. Online ahead of print. ABSTRACT Galectin-3 (Gal-3) is implicated in innate immune cell activation in a host of diseases/conditions. We identified a unique response whereby human basophils secrete IL-4/IL-13 when co-cultured with A549 cells -a lung adenocarcinoma. While displaying parameters consistent with standard IgE-dependent activation, these Galectin-3-dependent … Read more