Journal of Leukocyte Biology

J Leukoc Biol. 2025 Sep 26:qiaf134. doi: 10.1093/jleuko/qiaf134. Online ahead of print. ABSTRACT The immune response to Trypanosoma cruzi infection relies on robust inflammatory activation of macrophages and proper CD8+ T cells function to control parasite replication. However, an exacerbated respiratory burst from macrophages can damage tissues where parasites reside, such as the heart and … Read more

J Leukoc Biol. 2025 Sep 26:qiaf132. doi: 10.1093/jleuko/qiaf132. Online ahead of print. ABSTRACT Understanding the impact of Neutrophils and Macrophages in the dynamic outcome of resolution vs uncontrolled response is still an open debate. Here, we develop a mathematical model that describe the dynamic of the innate immune response after an acute damage. Our model … Read more

J Leukoc Biol. 2025 Sep 25:qiaf136. doi: 10.1093/jleuko/qiaf136. Online ahead of print. ABSTRACT Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipid-laden necrotic macrophages within blood vessels walls. GATA2 is a normally hematopoietic transcription factor which in the bone marrow helps maintain the proliferative, non-differentiated phenotype of hematopoietic progenitors. Unexpectedly, GATA2 is … Read more

J Leukoc Biol. 2025 Sep 25:qiaf133. doi: 10.1093/jleuko/qiaf133. Online ahead of print. ABSTRACT Low density granulocytes (LDG) are a population of predominantly neutrophils that sit within the peripheral blood mononuclear cell layer following density centrifugation. Their presence in various inflammatory conditions raises the question of their role in disease pathogenesis. LDG may be a heterogeneous … Read more

J Leukoc Biol. 2025 Sep 23:qiaf135. doi: 10.1093/jleuko/qiaf135. Online ahead of print. NO ABSTRACT PMID:40986660 | DOI:10.1093/jleuko/qiaf135

J Leukoc Biol. 2025 Sep 17:qiaf131. doi: 10.1093/jleuko/qiaf131. Online ahead of print. ABSTRACT Recent research suggests higher circulating lymphocyte counts may protect against colorectal cancer (CRC). However, the role of specific lymphocyte subtypes and activation states remain unclear. CD4+ T cells – a highly dynamic lymphocyte subtype – undergo gene expression changes upon activation that … Read more

J Leukoc Biol. 2025 Sep 17:qiaf130. doi: 10.1093/jleuko/qiaf130. Online ahead of print. ABSTRACT Rheumatoid arthritis (RA) is a prevalent autoimmune disorder with an elusive pathogenesis, hindering early detection and therapeutic advancements. This study focuses on CD39+ T cells, which play a significant role in RA, to identify diagnostic and therapeutic biomarkers. We analyzed scRNA-seq data … Read more

J Leukoc Biol. 2025 Sep 12:qiaf129. doi: 10.1093/jleuko/qiaf129. Online ahead of print. ABSTRACT Autoinflammatory diseases such as CAPS (Cryopyrin-Associated Periodic Fever Syndrome) and FMF (Familial Mediterranean Fever) involve an aberrant secretion of interleukin-1β (IL-1β) due to genetic defects in the NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) or pyrin inflammasomes. The regulatory mechanisms and … Read more

J Leukoc Biol. 2025 Sep 10:qiaf127. doi: 10.1093/jleuko/qiaf127. Online ahead of print. ABSTRACT Ion channels are integral membrane proteins which facilitate rapid transport of small ions into and out of the cell and between organelles and cytosol. Cytolytic lymphocytes including natural killer (NK) cells principally kill virus-infected and cancer cells by releasing cytolytic granules within … Read more

J Leukoc Biol. 2025 Sep 9:qiaf128. doi: 10.1093/jleuko/qiaf128. Online ahead of print. ABSTRACT There is limited understanding of the impact of anti-IL5 treatment on nasal polyp tissue biology in chronic rhinosinusitis with nasal polyps (CRSwNP). This study examined nasal polyp tissue cellular proteome and transcriptome responses to anti-IL5 treatment in CRSwNP utilising spatial profiling. GeoMx™ … Read more