J Leukoc Biol. 2026 Jan 8:qiag007. doi: 10.1093/jleuko/qiag007. Online ahead of print. ABSTRACT Bazedoxifene is a selective estrogen receptor modulator that is prescribed to menopausal women to treat symptoms of estrogen deficiency. Furthermore, bazedoxifene is being considered for cancer therapeutics due to its ability to block IL-6 signaling. However, various selective estrogen receptor modulators have … Read more

J Leukoc Biol. 2026 Jan 5:qiaf189. doi: 10.1093/jleuko/qiaf189. Online ahead of print. ABSTRACT CD101 is a disulfide-linked immunoglobulin-like glycoprotein with a unique glutamine-tryptophan-isoleucine (EWI) sequence motif. Allelic variations within the Cd101 gene can influence CD101 expression and function of different myeloid cell and T lymphocyte populations. CD101 serves also as maturation marker for neutrophils and … Read more

J Leukoc Biol. 2026 Jan 5:qiag001. doi: 10.1093/jleuko/qiag001. Online ahead of print. ABSTRACT IKZF3/Aiolos is a zinc-finger transcriptional transcription factor that functions as a transcriptional repressor in B cell development. IKZF3 mutations are associated with human diseases including immunodeficiency, leukemia and lymphoma. H195Y IKZF3 mutation was discovered in a mouse model of precursor B cell … Read more

J Leukoc Biol. 2026 Jan 5:qiag002. doi: 10.1093/jleuko/qiag002. Online ahead of print. ABSTRACT Tumor necrosis factor-α (TNF) and its receptors have emerged as key players in autoimmunity but also influence tumor development and the tumor microenvironment in many ways. TNF-inhibiting biologics are used very successfully in the clinic to treat autoimmune diseases. However, in some … Read more

J Leukoc Biol. 2026 Jan 2:qiaf188. doi: 10.1093/jleuko/qiaf188. Online ahead of print. ABSTRACT Changes in specific immune cell lineages, such as T and B cells, play a central role in the pathogenesis of rheumatoid arthritis (RA). However, a comprehensive evaluation of systemic immune cell changes in RA remains limited. Immune cell proportions of 104 subsets … Read more

J Leukoc Biol. 2025 Dec 26;118(1):qiaf169. doi: 10.1093/jleuko/qiaf169. ABSTRACT Severe burns complicated by acute lung injury are critical causes of respiratory failure and multiple organ dysfunction syndrome. Neutrophils extensively infiltrate lung tissues early postburn to mediate pulmonary damage, but the underlying mechanisms remain unclear. We analyzed gut microbiota of severe burn patients via metagenomics and … Read more

J Leukoc Biol. 2025 Dec 30:qiaf187. doi: 10.1093/jleuko/qiaf187. Online ahead of print. ABSTRACT Cholesterol metabolism plays a pivotal role in gastrointestinal (GI) cancers, from fuelling tumor growth, facilitating metastatic niche formation, shaping tumor immunosuppressive microenvironment to promoting immunotherapy resistance. Paradoxically, cholesterol may also exert context-dependent protective effects. Statins, the most widely prescribed cholesterol-lowering drugs, function … Read more

J Leukoc Biol. 2025 Dec 24:qiaf182. doi: 10.1093/jleuko/qiaf182. Online ahead of print. ABSTRACT Neutrophil extracellular traps (NETs) have been increasingly recognized as important modulators of tumor immunity. In this study, we investigated the prognostic significance of NETs-related genes expression and their impact on tertiary lymphoid structures (TLSs) in lung adenocarcinoma (LUAD). Using transcriptomic data from … Read more

J Leukoc Biol. 2025 Dec 24:qiaf184. doi: 10.1093/jleuko/qiaf184. Online ahead of print. ABSTRACT Relapse and therapy resistance remain major barriers to improving clinical outcomes in acute myeloid leukemia (AML), underscoring the need for actionable therapeutic targets. In this study, we identify calcium/calmodulin-dependent protein kinase II delta (CaMKIIδ) as a novel vulnerability in AML. CaMKIIδ is … Read more

J Leukoc Biol. 2025 Dec 22:qiaf183. doi: 10.1093/jleuko/qiaf183. Online ahead of print. ABSTRACT Sjögren’s disease (SjD) is a systemic autoimmune disease. The underlying disease mechanisms remain poorly understood and there are no curative therapies. MyD88-mediated signaling is essential for SjD, although the pathways that rely on MyD88 are not well characterized. Our objective was to … Read more