J Leukoc Biol. 2025 Nov 4;117(11):qiaf149. doi: 10.1093/jleuko/qiaf149. NO ABSTRACT PMID:41296542 | DOI:10.1093/jleuko/qiaf149
J Leukoc Biol. 2025 Nov 4;117(11):qiaf152. doi: 10.1093/jleuko/qiaf152. ABSTRACT Sepsis is a life-threatening condition driven by a dysregulated host response to infection, in which the innate immune axis-particularly the crosstalk between neutrophils and macrophages-plays a central role in dictating disease trajectory. This review delineates the functional, metabolic, and spatial characteristics of these two phagocytic cell … Read more
J Leukoc Biol. 2025 Nov 20:qiaf167. doi: 10.1093/jleuko/qiaf167. Online ahead of print. ABSTRACT IRGM proteins are associated with increased susceptibility to Crohn’s disease, mycobacterial infections, sepsis, and other inflammatory diseases, but the cells in which they function in vivo have not been delineated. To address this, mice with conditional deletions of Irgm1 were created and … Read more
J Leukoc Biol. 2025 Nov 4;117(11):qiaf138. doi: 10.1093/jleuko/qiaf138. ABSTRACT Natural killer (NK) cells are the first line of defense against viral infections and tumors. Their cytotoxic activity relies on the formation of an immune synapse (IS) with target cells. The lymphocyte function-associated antigen (LFA)-1 plays a central role in NK cell cytotoxicity by modulating NK-IS … Read more
J Leukoc Biol. 2025 Nov 17:qiaf165. doi: 10.1093/jleuko/qiaf165. Online ahead of print. ABSTRACT Patients who survive sepsis experience a prolonged period of immunosuppression. This period is accompanied by the expansion of monocytic myeloid-derived suppressor cells (M-MDSCs), a subset of suppressive myeloid cells; however, the impact of M-MDSCs on the innate immune response to infection is … Read more
J Leukoc Biol. 2025 Nov 17:qiaf166. doi: 10.1093/jleuko/qiaf166. Online ahead of print. ABSTRACT Gamma-aminobutyric acid (GABA), a non-protein component amino acid, functions as an inhibitory neurotransmitter. Here, we showed that GABA levels are significantly elevated in the bone marrow (BM) liquid of patients with multiple myeloma (MM) compared to healthy donors (HDs). Moreover, BM GABA … Read more
J Leukoc Biol. 2025 Nov 14:qiaf164. doi: 10.1093/jleuko/qiaf164. Online ahead of print. ABSTRACT Following the 2025 Nobel Prize in Physiology or Medicine for the discovery of regulatory T cells (Tregs), a recent article in Nature Communications reports the creation of allogeneic, genome-edited Tregs engineered to evade immune rejection while retaining suppressive function. Through non-viral CRISPR … Read more
J Leukoc Biol. 2025 Nov 13:qiaf163. doi: 10.1093/jleuko/qiaf163. Online ahead of print. ABSTRACT Mycoplasma pneumoniae (Mp) is a frequent cause of pediatric pneumonia, largely due to the challenges in early detection and the tendency to underestimate the severity of infections. Emerging evidence suggests that ATP-binding cassette transporter G1 (ABCG1) plays a critical role in preventing … Read more
J Leukoc Biol. 2025 Nov 10:qiaf161. doi: 10.1093/jleuko/qiaf161. Online ahead of print. ABSTRACT Neutrophils, our frontline of defense against pathogens, exhibit pronounced sexual dimorphism in ontogeny, phenotype, and effector functions. Throughout the human lifespan, estrogen and androgen signaling, together with sex-linked genetic regulators, orchestrate neutrophil production, maturation, and immune activity, contributing to immunological differences between … Read more
J Leukoc Biol. 2025 Nov 10:qiaf155. doi: 10.1093/jleuko/qiaf155. Online ahead of print. ABSTRACT Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, affects millions worldwide, with a high prevalence in Latin America, representing a significant public health burden. The transition from the asymptomatic acute phase to the chronic stage, where about 30% of individuals develop … Read more
