Journal of Leukocyte Biology

J Leukoc Biol. 2025 Aug 5:qiaf117. doi: 10.1093/jleuko/qiaf117. Online ahead of print. ABSTRACT Immune function alters as we age, and is often accompanied by chronic, low-grade inflammation termed inflammageing. This leads cells to develop a senescence-associated secretory phenotype (SASP) and release a range of pro-inflammatory cytokines and proteolytic enzymes. In individuals with frailty, inflammaging and … Read more

J Leukoc Biol. 2025 Aug 5;117(8):qiaf089. doi: 10.1093/jleuko/qiaf089. ABSTRACT Cyclophilin A (CypA) is a member of the isomerase family; in the secreted form, it acts as a chemoattractant and pro-inflammatory factor, orchestrating the development of the local inflammatory response. In this work, we studied the role of secreted CypA in regulating an adaptive immune response. … Read more

J Leukoc Biol. 2025 Aug 7:qiaf114. doi: 10.1093/jleuko/qiaf114. Online ahead of print. ABSTRACT Macrophages have a dual role in tissue healing after injury as they perform tissue repair functions but can also precipitate tissue damage or promote fibrosis. Platelets, beyond their role in thrombosis and hemostasis, are crucial mediators of inflammation and interact with macrophages. … Read more

J Leukoc Biol. 2025 Aug 7:qiaf109. doi: 10.1093/jleuko/qiaf109. Online ahead of print. ABSTRACT The ejection of neutrophil extracellular trap (NET) is one of the characteristic features of neutrophils. Rapid release of NET-containing extracellular vesicles (NET-EVs) to the extracellular space has been reported as a novel NET-release mechanism in response to Staphylococcus aureus. An increased number … Read more

J Leukoc Biol. 2025 Aug 1:qiaf113. doi: 10.1093/jleuko/qiaf113. Online ahead of print. ABSTRACT Neutrophils are essential components of the innate immune system, playing a critical role in responding to infections and inflammation. Their recruitment from blood circulation to affected tissues follows a well-coordinated multistep adhesion and activation cascade. Recent studies highlight the importance of posttranslational … Read more

J Leukoc Biol. 2025 Jul 31:qiaf111. doi: 10.1093/jleuko/qiaf111. Online ahead of print. ABSTRACT Morphologic studies show increased mast cell activation during T cell-mediated inflammation. Previous research demonstrated that microvesicles from activated T cells (MVT*), but not resting T cells (MVT), stimulate human mast cells via the MAPK pathway, leading to degranulation and cytokine release. This … Read more

J Leukoc Biol. 2025 Jul 31:qiaf110. doi: 10.1093/jleuko/qiaf110. Online ahead of print. ABSTRACT Psoriasis is a systemic inflammatory skin disorder with a prevalence of 2 % in adults. Up to 30 % of affected individuals further develop psoriatic arthritis (PsA), which is characterized by additional joint inflammation. Myeloperoxidase (MPO) is strongly expressed by neutrophils and, … Read more

J Leukoc Biol. 2025 Jul 24:qiaf108. doi: 10.1093/jleuko/qiaf108. Online ahead of print. ABSTRACT When I think about scientific/professional “legacy”, for me there are at least 3 areas to consider: 1) the actual scientific legacy you (and your lab members) have contributed to; 2) the people you have touched and how they touch you in this … Read more

J Leukoc Biol. 2025 Jul 22:qiaf107. doi: 10.1093/jleuko/qiaf107. Online ahead of print. ABSTRACT Natural killer (NK) cells represent a promising effector population for tumor immunotherapy. Conventional NK cell engagers (NKCEs), primarily targeting CD16a, show efficacy but face limitations due to receptor polymorphisms and off-target toxicity. Here, we report the development and characterization of a novel … Read more

J Leukoc Biol. 2025 Jul 22:qiaf106. doi: 10.1093/jleuko/qiaf106. Online ahead of print. ABSTRACT Chronic Graft versus Host Disease (cGvHD) is a major late determinant of transplant related mortality (TRM) after allogeneic stem cell transplantation (HSCT). We investigated the predictive value of peripheral blood activated HLA-DR+CD3+ T cells as a novel biomarker. In total, 107 patients … Read more