Journal of Leukocyte Biology

J Leukoc Biol. 2025 Apr 23;117(4):qiaf014. doi: 10.1093/jleuko/qiaf014. ABSTRACT The NOD-like receptor family, particularly the protein 3 that contains the pyrin domain (NLRP3), is an intracellular sensing protein complex responsible for detecting patterns associated with pathogens and injuries. NLRP3 plays a crucial role in the innate immune response. Currently, a wide range of research has … Read more

J Leukoc Biol. 2025 Apr 25:qiaf053. doi: 10.1093/jleuko/qiaf053. Online ahead of print. ABSTRACT Severe fever with thrombocytopenia syndrome is a life-threatening condition that has been the focus of attention in recent years. It is primarily caused by uncontrolled replication of a novel Bunyavirus and an intense pro-inflammatory response. NETosis is a form of cell death … Read more

J Leukoc Biol. 2025 Apr 25:qiaf052. doi: 10.1093/jleuko/qiaf052. Online ahead of print. ABSTRACT Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4), an emerging immune checkpoint molecule, exhibits therapeutic potential in acute myeloid leukemia (AML). While single nucleotide polymorphisms (SNPs) of immune checkpoint genes have been extensively investigated in AML, the association between LILRB4 genetic polymorphisms … Read more

J Leukoc Biol. 2025 Apr 24:qiaf048. doi: 10.1093/jleuko/qiaf048. Online ahead of print. ABSTRACT Atypical B cells or age-associated B cells (ABCs) represent an alternative lineage of memory B cells. Emerging evidence suggests that context influences the apparent functional heterogeneity of ABCs. While data support a protective role for ABCs in the setting of infection, multiple … Read more

J Leukoc Biol. 2025 Apr 23:qiaf050. doi: 10.1093/jleuko/qiaf050. Online ahead of print. ABSTRACT Neutrophils are vital immune cells involved in immunity via their effector roles and death. While their rapid response to the environment is crucial for immune function, it also makes them difficult to study. Here, we provide a no-lyse no-wash (NLNW) flow cytometry … Read more

J Leukoc Biol. 2025 Apr 17:qiaf049. doi: 10.1093/jleuko/qiaf049. Online ahead of print. ABSTRACT Neutrophils are the most abundant leukocytes in the circulation and critical players in host defense and inflammation. They respond rapidly to numerous biological, chemical, and physical stimuli, making it challenging to characterize their steady-state phenotypes, activation states, and subsets in an unbiased … Read more

J Leukoc Biol. 2025 Apr 17:qiaf047. doi: 10.1093/jleuko/qiaf047. Online ahead of print. ABSTRACT Bone marrow-derived dendritic cell (BMDC) activation is associated with rewiring of cellular metabolism and concurrent large-scale changes in gene expression promoting a pro-inflammatory program characterized by expression of inducible nitric oxide synthase (iNOS) and the production of nitric oxide (NO). NO inhibits … Read more

J Leukoc Biol. 2025 Apr 16:qiaf045. doi: 10.1093/jleuko/qiaf045. Online ahead of print. ABSTRACT Dendritic cells (DCs) are rare innate immune cells that are essential regulators of anti-tumour, anti-viral and vaccine responses by the adaptive immune system. Conventional dendritic cells, particularly the cDC1 subset, are most desired for DC-based immunotherapies, however, it can be difficult to … Read more

J Leukoc Biol. 2025 Apr 16:qiaf044. doi: 10.1093/jleuko/qiaf044. Online ahead of print. ABSTRACT Natural Killer (NK cells) are known for their killing function in infection- and tumor-related responses, but also can shape immune responses involved in physiological processes such as wound healing. We recently reported that NK cells accumulate in skin wounds and express pro-inflammatory … Read more

J Leukoc Biol. 2025 Apr 15:qiaf043. doi: 10.1093/jleuko/qiaf043. Online ahead of print. ABSTRACT Recent studies have challenged the traditional view of innate immunity as non-specific and transient by demonstrating that innate immune cells can develop immune memory in response to various activating factors, a phenomenon known as trained immunity. This process involves epigenetic modifications, such … Read more