Journal of Leukocyte Biology

Distinct roles of PGE2 signaling via EP2 and EP4 in circulating pDCs: implications for immune modulation in the tumor microenvironment​Jorge Cuenca-Escalona on 21 de March de 2025 at 10:00

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J Leukoc Biol. 2025 Mar 21:qiaf034. doi: 10.1093/jleuko/qiaf034. Online ahead of print. ABSTRACT Dendritic cells (DCs) play a pivotal role in orchestrating adaptive immunity in response to environmental cues such as prostaglandin E2 (PGE2). Tumors are known to establish a microenvironment rich in PGE2. Tumor-derived PGE2 is regarded as mediator of regulatory features in DCs, … Read more

Early neutrophil responses are potential biomarkers to predict severe COVID-19 in adults​Ananya Singh on 20 de March de 2025 at 10:00

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J Leukoc Biol. 2025 Mar 20:qiaf035. doi: 10.1093/jleuko/qiaf035. Online ahead of print. ABSTRACT In the early COVID-19 pandemic, the strain on healthcare facilities highlighted the need for reliable biomarkers to predict progression to severe COVID-19. Neutrophils, the most abundant leukocytes in circulation, are early defenders against pathogens. In a Singaporean adult cohort, early neutrophil mediators … Read more

Sex differences in age-related cardiac and splenic S100A9 and NLRP3 expression​Kathleen Pappritz on 14 de March de 2025 at 10:00

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J Leukoc Biol. 2025 Mar 15:qiaf031. doi: 10.1093/jleuko/qiaf031. Online ahead of print. ABSTRACT Age is an important risk factor for cardiovascular diseases (CVD) and associated with a systemic, low-grade inflammation, so called “inflammaging”. We aimed to investigate the impact of age and sex on the inflammatory markers S100A9 and components of the NLRP3 inflammasome at … Read more

Afucosylated broadly neutralising antibodies targeting HIV envelope elicit enhanced NK cell-mediated cytotoxicity against HIV-infected CD4+ T cell and macrophage targets​Olivia Wilhelm on 14 de March de 2025 at 10:00

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J Leukoc Biol. 2025 Mar 15:qiaf033. doi: 10.1093/jleuko/qiaf033. Online ahead of print. ABSTRACT Enhancement of antibody-dependent cellular cytotoxicity (ADCC) is a promising adjunct approach to achieve HIV control in the absence of antiretroviral therapy but requires the development of potent ADCC-eliciting antibodies which can recognise diverse HIV-infected cell types. A panel of broadly neutralising antibodies … Read more

Anti-TNF therapy in the treatment of systemic autoinflammatory diseases: the responses of innate immune cells​Shuyi Wang on 14 de March de 2025 at 10:00

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J Leukoc Biol. 2025 Mar 14:qiaf026. doi: 10.1093/jleuko/qiaf026. Online ahead of print. ABSTRACT Systemic autoinflammatory diseases (SAIDs) are rare conditions resulting from innate immune system dysregulation, culminating in repetitive bouts of systemic inflammation without the presence of external or self-antigens. Most SAIDs are associated with mutations in genes affecting the innate immune response. Tumor necrosis … Read more

Utility of the NLR and the ratio of NLR after and before adverse events for differential diagnosis of irAEs and bacterial infections in cancer patients treated with PD-(L)1 inhibitors​Lu Han on 14 de March de 2025 at 10:00

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J Leukoc Biol. 2025 Mar 14:qiaf029. doi: 10.1093/jleuko/qiaf029. Online ahead of print. ABSTRACT Differential diagnosis of immune-related adverse events (irAEs) or bacterial infections is sometimes very difficulty in cancer patients undergoing treatment with PD-(L)1 inhibitors. This study aimed to assess the effectiveness of the neutrophil-to-lymphocyte ratio (NLR) in distinguishing between irAEs and bacterial infections in … Read more

Characterizing a Low-Density Neutrophil gene signature in acute and chronic infections and its impact on disease severity​Matheus Aparecido de Toledo on 4 de March de 2025 at 11:00

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J Leukoc Biol. 2025 Mar 3:qiaf027. doi: 10.1093/jleuko/qiaf027. Online ahead of print. ABSTRACT Low-density neutrophils (LDNs) or polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) are involved in the pathogenesis of cancer, autoimmune and infectious diseases. They are crucial in the host-response to invading pathogens, especially during acute illness, and are associated with poor prognosis in many infectious … Read more

Suppression of NF-κB/NLRP3 by Nanoligomer Therapy Mitigates Ethanol and Advanced Age-Related Neuroinflammation​Paige E Anton on 4 de March de 2025 at 11:00

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J Leukoc Biol. 2025 Feb 27:qiaf024. doi: 10.1093/jleuko/qiaf024. Online ahead of print. ABSTRACT Binge alcohol use is increasing among aged adults (>65 years). Alcohol-related toxicity in aged adults is associated with neurodegeneration, yet the molecular underpinnings of this age-related sensitivity to alcohol are not well described. Studies utilizing rodent models of neurodegenerative disease reveal heightened … Read more

High-dimensional spectral flow cytometry of activation and phagocytosis by peripheral human polymorphonuclear leukocytes​Evan R Lamb on 4 de March de 2025 at 11:00

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J Leukoc Biol. 2025 Feb 26:qiaf025. doi: 10.1093/jleuko/qiaf025. Online ahead of print. ABSTRACT Polymorphonuclear leukocytes (PMNs) are terminally differentiated phagocytes with pivotal roles in infection, inflammation, tissue injury, and resolution. PMNs display a breadth of responses to diverse endogenous and exogenous stimuli, making understanding of these innate immune responders vital yet challenging to achieve. Here, … Read more

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