J Leukoc Biol. 2024 Oct 25:qiae227. doi: 10.1093/jleuko/qiae227. Online ahead of print. ABSTRACT Natural Killer (NK) cells are critical innate immune cells involved in the clearance of virally infected and malignant cells. Human NK cells are distinguished by their surface expression of CD56 and a lack of CD3. While CD56 expression and cell surface density … Read more

J Leukoc Biol. 2024 Oct 24:qiae232. doi: 10.1093/jleuko/qiae232. Online ahead of print. ABSTRACT Blood and airway eosinophilia represent markers for the endotype-driven treatment of allergic asthma. Little is known on mechanisms that link eosinophils and airway epithelial cells before and after these cells are infiltrated by eosinophils during allergic response. Given that innate immune mechanisms, … Read more

J Leukoc Biol. 2024 Oct 24:qiae237. doi: 10.1093/jleuko/qiae237. Online ahead of print. ABSTRACT The role of MIR654 in Burkitt’s lymphoma (BL) and whether it impacts expression of MYC, and its downstream activated MIR9 is not known. Expression of MYC, MYCN, MYCL, MIR9/3P, MIR654/5P, and MIR654/3P were assessed by qRT-PCR in biopsy samples from Epstein-Barr virus … Read more

J Leukoc Biol. 2024 Oct 24:qiae236. doi: 10.1093/jleuko/qiae236. Online ahead of print. ABSTRACT Rheumatoid arthritis is a common autoimmune disease, but little is known about the characteristics of the B cell repertoires in the peripheral blood. In this study, the peripheral IgM repertoires of early rheumatoid arthritis (ERA) patients were analyzed by high-throughput sequencing and … Read more

J Leukoc Biol. 2024 Oct 22:qiae231. doi: 10.1093/jleuko/qiae231. Online ahead of print. ABSTRACT The impact of aging on T cell subsets, specifically CD4+ and CD8+ T cells, leading to immune system dysfunction, has been the focus of scientific investigation due to its potential to reverse age-associated deterioration. Transcriptomic and epigenomic studies have identified the primary … Read more

J Leukoc Biol. 2024 Oct 21:qiae223. doi: 10.1093/jleuko/qiae223. Online ahead of print. ABSTRACT Although the SARS-CoV-2 infection has established risk groups, identifying biomarkers for disease outcomes is still crucial to stratify patient risk and enhance clinical management. Optimal efficacy of COVID-19 antiviral medications relies on early administration within the initial five days of symptoms, assisting … Read more

J Leukoc Biol. 2024 Oct 21:qiae233. doi: 10.1093/jleuko/qiae233. Online ahead of print. ABSTRACT Galectin-3 (Gal-3) is implicated in innate immune cell activation in a host of diseases/conditions. We identified a unique response whereby human basophils secrete IL-4/IL-13 when co-cultured with A549 cells -a lung adenocarcinoma. While displaying parameters consistent with standard IgE-dependent activation, these Galectin-3-dependent … Read more

J Leukoc Biol. 2024 Oct 21:qiae229. doi: 10.1093/jleuko/qiae229. Online ahead of print. ABSTRACT Acute graft-versus-host disease (aGVHD) represents the rejection of the recipient’s skin, gut, and liver tissues of an allogeneic hematopoietic stem cell transplantation (HSCT) by the donor T-cells. The onset of aGVHD is often rapid and its evolution is unpredictable. We undertook the … Read more

J Leukoc Biol. 2024 Oct 18:qiae226. doi: 10.1093/jleuko/qiae226. Online ahead of print. ABSTRACT Immune therapy using checkpoint inhibitors or adoptive cell transfer has revolutionized the treatment of several types of cancers. However, response to treatment is currently limited to a fraction of patients. Elucidation of immune modulatory mechanisms might optimize patient selection and present ways … Read more

J Leukoc Biol. 2024 Oct 18:qiae230. doi: 10.1093/jleuko/qiae230. Online ahead of print. ABSTRACT Historically, the nervous and immune systems were studied as separate entities. The nervous system relays signals between the body and the brain by processing sensory inputs and executing motor outputs, whereas the immune system provides protection against injury and infection through inflammation. … Read more