Journal of Leukocyte Biology

Enhanced Siglec-8 and HLA-DR and Reduced CRTH2 Surface Expression, Highlight a Distinct Phenotypic Signature of Circulating Eosinophils in Atopic Dermatitis​Frédéric Dezoteux on 25 de February de 2025 at 11:00

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J Leukoc Biol. 2025 Feb 25:qiaf023. doi: 10.1093/jleuko/qiaf023. Online ahead of print. ABSTRACT Atopic dermatitis (AD) as well as other type 2 immune response (T2) diseases are often linked to elevated eosinophil (Eos) levels in the blood. Although the role of Eos in AD pathophysiology is suspected, it remains unclear. The development of new treatments … Read more

Histones HIST1 genes and tumor infiltrating lymphocytes in a child with gamma delta T cell acute lymphoblastic leukemia by single-cell sequencing​Xiao-Hua Luo on 20 de February de 2025 at 11:00

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J Leukoc Biol. 2025 Feb 20:qiaf022. doi: 10.1093/jleuko/qiaf022. Online ahead of print. ABSTRACT Gamma delta T-cell acute lymphoblastic leukemia (γδ T-ALL) represents a rare subset of T-ALL and is correlated with high rates of induction failure, relapse and increased mortality. γδ T-ALL lacks a biologically-informed framework for guiding its classification and treatment strategies. In this … Read more

MiR-340-5p alleviates AECOPD by targeting MAP3K2 via Qingjin Huatan Decoction therapy​Mei Zhao on 20 de February de 2025 at 11:00

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J Leukoc Biol. 2025 Feb 20:qiaf021. doi: 10.1093/jleuko/qiaf021. Online ahead of print. ABSTRACT Chronic obstructive pulmonary disease (COPD) features persistent inflammation and restricted airflow, with acute exacerbations of COPD (AECOPD) significantly worsening patient outcomes. This study aims to explore the role of Qingjin Huatan Decoction (QJHTT) on AECOPD with the syndrome of phlegm-heat obstruction of … Read more

How to focus on autoantigen-specific lymphocytes: a review on diagnosis and treatment of Sjogren’s syndrome​Bingxia Ming on 15 de February de 2025 at 11:00

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J Leukoc Biol. 2025 Feb 13;117(2):qiae247. doi: 10.1093/jleuko/qiae247. ABSTRACT Sjogren’s syndrome (SS) is an autoimmune epithelitis characterized by focal lymphocytic infiltration against self-antigens leading to progressive glandular dysfunction, which can develop to multisystem manifestation. The classification criteria for SS emphasizes glandular lymphocyte infiltrates and anti-SSA/SSB seropositivity, which is usually manifested in advanced patients. Therapeutically, apart … Read more

Risk beyond neutropenia: insights into neutrophil migration from newly diagnosed AML until late after allogeneic stem cell transplantation​Zülal Cibir on 15 de February de 2025 at 11:00

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J Leukoc Biol. 2025 Feb 13;117(2):qiae250. doi: 10.1093/jleuko/qiae250. ABSTRACT Quantification of neutrophil counts is the most relevant assessment of cellular immunity in clinical practice. Patients with neutropenia are considered at risk and are categorized according to its severity. The incidence of febrile neutropenia varies, but patients with acute myeloid leukemia are traditionally considered at high … Read more

Development of 2LTRZFP-expressing induced pluripotent stem cells as a potential anti-HIV-1 gene therapy against viral integration​Kritayaporn Saiprayong on 13 de February de 2025 at 11:00

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J Leukoc Biol. 2025 Feb 13:qiaf018. doi: 10.1093/jleuko/qiaf018. Online ahead of print. ABSTRACT Highly active antiretroviral drug (HAART) is the standard treatment for HIV-1 infection to suppress the viral load. However, this treatment does not completely eradicate the virus; it simply decreases the viral load to undetectable levels. The development of a novel therapy to … Read more

Fc gamma receptors activate different protein kinase C isoforms in human neutrophils​Omar Rafael Alemán on 13 de February de 2025 at 11:00

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J Leukoc Biol. 2025 Feb 13:qiaf019. doi: 10.1093/jleuko/qiaf019. Online ahead of print. ABSTRACT Receptors for the Fc portion of IgG antibodies (FcγR) on human neutrophils constitute an important mechanism for recognition of opsonized microorganisms and for cell activation. Human neutrophils express two FcγR: FcγRIIa and FcγRIIIb. Previously, it has been reported that activation of each … Read more

Multifaceted roles of neutrophils in cardiac disease​Samantha Morrissey on 12 de February de 2025 at 11:00

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J Leukoc Biol. 2025 Feb 12:qiaf017. doi: 10.1093/jleuko/qiaf017. Online ahead of print. ABSTRACT Neutrophils, the most abundant leukocytes in human blood, have long been recognized as critical first responders in the innate immune system’s defense against pathogens. Some of the more notable innate anti-microbial properties of neutrophils include generation of superoxide free radicals like myeloperoxidase … Read more

The role of CD57+γδ T cells in the immune pathogenesis of patients with sepsis​Liman Li on 12 de February de 2025 at 11:00

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J Leukoc Biol. 2025 Feb 12:qiaf015. doi: 10.1093/jleuko/qiaf015. Online ahead of print. ABSTRACT The immune response goes haywire during sepsis. The aim of this study was to explore the role of CD57+γδ T cells in the immune pathogenesis of sepsis. We characterized the transcriptomic profile of peripheral γδ T cells obtained from patients with sepsis … Read more

Extended repertoire of CXC chemokines acting as agonists and antagonists of the human and murine atypical chemokine receptor ACKR2​Rafael Luís on 4 de February de 2025 at 11:00

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J Leukoc Biol. 2025 Feb 4:qiaf013. doi: 10.1093/jleuko/qiaf013. Online ahead of print. ABSTRACT Atypical chemokine receptors (ACKRs) are a subfamily of important regulators of chemokine functions. Among them, ACKR2 has long been considered as a scavenger of multiple inflammatory chemokines exclusively from the CC family. Recently, we demonstrated the ability of ACKR2 to scavenge the … Read more

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