Journal of Leukocyte Biology

J Leukoc Biol. 2025 Apr 15:qiaf043. doi: 10.1093/jleuko/qiaf043. Online ahead of print. ABSTRACT Recent studies have challenged the traditional view of innate immunity as non-specific and transient by demonstrating that innate immune cells can develop immune memory in response to various activating factors, a phenomenon known as trained immunity. This process involves epigenetic modifications, such … Read more

J Leukoc Biol. 2025 Apr 11:qiaf042. doi: 10.1093/jleuko/qiaf042. Online ahead of print. ABSTRACT Inhibiting the metabolic activity of CD4+ T cells can effectively reduce HIV infection. Mitochondria, as critical organelles in eukaryotic metabolism, play a significant role in the progression of many diseases. The change of mitochondrial dynamics is an important process of mitochondrial regulation … Read more

J Leukoc Biol. 2025 Apr 9:qiaf041. doi: 10.1093/jleuko/qiaf041. Online ahead of print. NO ABSTRACT PMID:40203078 | DOI:10.1093/jleuko/qiaf041

J Leukoc Biol. 2025 Apr 5:qiaf039. doi: 10.1093/jleuko/qiaf039. Online ahead of print. ABSTRACT Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation. The ferroptosis mechanism involves complex interactions between fatty acid metabolism, iron metabolism, lipid peroxidation, and antioxidative defense mechanisms. Fatty acids, especially polyunsaturated fatty acids (PUFAs), are susceptible to … Read more

J Leukoc Biol. 2025 Apr 2:qiaf040. doi: 10.1093/jleuko/qiaf040. Online ahead of print. ABSTRACT Preterm neonates die at a significantly higher rate from sepsis than full-term neonates, attributable to their dysregulated immune response. In addition to tissue destruction caused directly by bacterial invasion, an overwhelming cytokine response by the immune cells to bacterial antigens also results … Read more

J Leukoc Biol. 2025 Mar 28:qiaf038. doi: 10.1093/jleuko/qiaf038. Online ahead of print. ABSTRACT BACKGROUND: Delayed cerebral ischemia (DCI) is a significant complication of aneurysmal subarachnoid hemorrhage (aSAH). This study profiled immune responses after aSAH and evaluated their association with DCI onset. METHODS: Twelve aSAH patients were enrolled. Leukocyte populations and cytokine levels were analyzed in … Read more

J Leukoc Biol. 2025 Mar 26:qiaf037. doi: 10.1093/jleuko/qiaf037. Online ahead of print. ABSTRACT Immune memory is a hallmark of the adaptive immune system. However, recent research reveals that innate immune cells also retain memory of prior pathogen exposure that prompts enhanced responses to subsequent infections. This phenomenon is termed “innate immune memory” or “trained immunity.” … Read more

J Leukoc Biol. 2025 Mar 21:qiaf034. doi: 10.1093/jleuko/qiaf034. Online ahead of print. ABSTRACT Dendritic cells (DCs) play a pivotal role in orchestrating adaptive immunity in response to environmental cues such as prostaglandin E2 (PGE2). Tumors are known to establish a microenvironment rich in PGE2. Tumor-derived PGE2 is regarded as mediator of regulatory features in DCs, … Read more

J Leukoc Biol. 2025 Mar 20:qiaf035. doi: 10.1093/jleuko/qiaf035. Online ahead of print. ABSTRACT In the early COVID-19 pandemic, the strain on healthcare facilities highlighted the need for reliable biomarkers to predict progression to severe COVID-19. Neutrophils, the most abundant leukocytes in circulation, are early defenders against pathogens. In a Singaporean adult cohort, early neutrophil mediators … Read more

J Leukoc Biol. 2025 Mar 18:qiaf030. doi: 10.1093/jleuko/qiaf030. Online ahead of print. NO ABSTRACT PMID:40098482 | DOI:10.1093/jleuko/qiaf030