Journal of Leukocyte Biology

J Leukoc Biol. 2025 Sep 3:qiaf126. doi: 10.1093/jleuko/qiaf126. Online ahead of print. ABSTRACT As its discovery nears a half century, the widespread use of F4/80 antigen as a differentiation marker of tissue macrophages of the mouse, continues to raise questions in and beyond experimental cellular immunology. Its structure as a 7 transmembrane G Protein Coupled … Read more

J Leukoc Biol. 2025 Sep 2:qiaf125. doi: 10.1093/jleuko/qiaf125. Online ahead of print. ABSTRACT Cellular senescence is a stress-induced program characterized by long-lasting cell cycle arrest and the secretion of bioactive and inflammatory molecules, which are collectively referred to as the senescence-associated secretory phenotype (SASP). Diverse stressors, including oncogene activation, chemotherapy, radiotherapy, and cytokine exposure, can … Read more

J Leukoc Biol. 2025 Sep 1:qiaf124. doi: 10.1093/jleuko/qiaf124. Online ahead of print. ABSTRACT CD57 is one of the biomarkers for immunosenescence, and its expression increases with age. This study aimed to analyze CD4+ T cell phenotypes and cytokine production (interferon-gamma [IFN-γ] and interleukin [IL]-17) and their association with cardiovascular disease (CVD) risk factors. Using multi-color … Read more

J Leukoc Biol. 2025 Aug 29:qiaf123. doi: 10.1093/jleuko/qiaf123. Online ahead of print. ABSTRACT Trained immunity amplifies innate immune responses in an antigen-independent manner. This study explored the ability of trained human primary macrophages to modulate the phenotype and function of T cells. Macrophages play an important role in antigen presentation, resulting in T-cell activation and … Read more

J Leukoc Biol. 2025 Aug 5;117(8):qiaf115. doi: 10.1093/jleuko/qiaf115. ABSTRACT We present a novel classification system for murine thymic epithelial cells (TECs), identifying 11 distinct types, four in the thymic cortex and seven in the medulla, based on their spatial localization and unique ultrastructural features. As key stromal components of the thymic microenvironment, TECs play indispensable … Read more

J Leukoc Biol. 2025 Aug 5;117(8):qiaf112. doi: 10.1093/jleuko/qiaf112. ABSTRACT Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in preterm infants and is a major health hazard for preterm infants worldwide. Hyperoxia-induced oxidative stress is one of the major risk factors for the development of BPD, and ideas for timely intervention in the development … Read more

J Leukoc Biol. 2025 Aug 5;117(8):qiaf084. doi: 10.1093/jleuko/qiaf084. ABSTRACT Tumor heterogeneity and the complex immune microenvironment make it challenging to identify candidates for immunotherapy using dominant biomarkers. Tumor-infiltrating CD8+T cells, particularly CD103+CD8+ tissue-resident T cells and their specific subsets, are generally linked to better outcomes in many cancers, but their role in renal cancer remains … Read more

J Leukoc Biol. 2025 Aug 21:qiaf122. doi: 10.1093/jleuko/qiaf122. Online ahead of print. ABSTRACT The insulin-like growth factor (IGF) axis is crucial for regulating cell growth, survival, and differentiation. While therapies targeting the IGF-1 receptor (IGF-1R) have shown limited clinical success as single agents, the abnormal expression of its ligands, IGF-I and IGF-II, has been shown … Read more

J Leukoc Biol. 2025 Aug 16:qiaf121. doi: 10.1093/jleuko/qiaf121. Online ahead of print. ABSTRACT Severe trauma releases damage-associated molecular patterns (DAMPs), which activate the immune system via pattern recognition receptors. This triggers inflammatory cascades that can lead to systemic inflammatory response syndrome, immunosuppression, and multiple organ dysfunction syndrome. Pyroptosis is an inflammatory form of cell death … Read more

J Leukoc Biol. 2025 Aug 14:qiaf120. doi: 10.1093/jleuko/qiaf120. Online ahead of print. ABSTRACT Existing studies examining the relationships among immunological cell phenotype, plasma metabolites, and pancreatic cancer susceptibility are limited. More comprehensive research is required to elucidate the complex interactions underlying these associations. Genetic instruments for 731 immune phenotypes (N = 3,757), 1,400 circulating metabolites … Read more