J Leukoc Biol. 2025 Dec 19:qiaf180. doi: 10.1093/jleuko/qiaf180. Online ahead of print. ABSTRACT Precursor exhausted and terminally exhausted T cells (Tpex and Tex) are associated with immune checkpoints, T-cell checkpoint blockade may improve patient survival. We assessed cytotoxic activity and PD-1/TIM-3 expressions of CD3+CD8+CD56+ T cells (NK-like T) in cytokine-induced killer (CIK) cells across exhaustion … Read more

J Leukoc Biol. 2025 Dec 15:qiaf181. doi: 10.1093/jleuko/qiaf181. Online ahead of print. ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy by enhancing anti-tumor immunity, but their use is frequently complicated by immune-related adverse events (irAEs), particularly ICI-induced diarrhea and colitis. Growing evidence suggests that RNA-binding proteins (RBPs), which are critical post-transcriptional regulators of immune … Read more

J Leukoc Biol. 2025 Dec 12:qiaf179. doi: 10.1093/jleuko/qiaf179. Online ahead of print. ABSTRACT While sex differences in neutrophil metabolism have been documented, whether this metabolic dimorphism extends to specific neutrophil subsets remains unknown.LDNs are characterized by their lower buoyant density compared to normal-density neutrophils(NDNs), are present in low numbers in healthy individuals, and are often … Read more

J Leukoc Biol. 2025 Dec 12:qiaf178. doi: 10.1093/jleuko/qiaf178. Online ahead of print. ABSTRACT Arthritis imposes a substantial global burden and remains without curative therapy. Among the most prevalent forms, rheumatoid arthritis (RA) and osteoarthritis (OA) differ in etiology but converge on pathogenic tumor necrosis factor-α (TNFα) signaling. A key regulatory node is TNFR2, which promotes … Read more

J Leukoc Biol. 2025 Dec 11:qiaf175. doi: 10.1093/jleuko/qiaf175. Online ahead of print. ABSTRACT Pediatric burn injury induces concurrent systemic inflammation and immune dysfunction, which is associated with adverse clinical outcomes (e.g., infections). For that reason, immunomodulating therapies, such as granulocyte macrophage colony-stimulating factor (GM-CSF), have been of great interest to augment the immune response following … Read more

J Leukoc Biol. 2025 Dec 8:qiaf172. doi: 10.1093/jleuko/qiaf172. Online ahead of print. ABSTRACT Ovarian cancer remains the most lethal gynecologic malignancy, due in part to the establishment of a profoundly immunosuppressive tumor microenvironment (TME). While toll-like receptor 5 (TLR5) signaling has previously been implicated in promoting myeloid cell recruitment to the ovarian TME, source(s) of … Read more

J Leukoc Biol. 2025 Dec 6:qiaf177. doi: 10.1093/jleuko/qiaf177. Online ahead of print. ABSTRACT Mucosal-associated invariant T (MAIT) cells are unique unconventional T cells with diverse roles in immunity, yet how their context informs their function is not well known. This contextual regulation is particularly relevant in cancer, where MAIT cells have an enigmatic role. We … Read more

J Leukoc Biol. 2025 Dec 5:qiaf171. doi: 10.1093/jleuko/qiaf171. Online ahead of print. ABSTRACT Eosinophils (EOS), named after the Greek dawn goddess Eos, are multifunctional granulocytes with roles surpassing their well-established involvement in allergic diseases and parasitic infections. Herein, we highlighted the recent advancements in understanding the cellular structure, lineage development, surface receptors, and diverse phenotypes … Read more

J Leukoc Biol. 2025 Dec 5:qiaf176. doi: 10.1093/jleuko/qiaf176. Online ahead of print. ABSTRACT Tumor-associated macrophages (TAM) exert both pro- and anti-tumoral functions that influence cancer progression and patient prognosis. However, single-cell RNA sequencing (scRNA-seq) studies have revealed that TAM heterogeneity remains incompletely characterized. By performing an unbiased, integrated in silico analyses of publicly available scRNA-seq … Read more

J Leukoc Biol. 2025 Dec 3:qiaf173. doi: 10.1093/jleuko/qiaf173. Online ahead of print. ABSTRACT Extracellular vesicles (EVs) are essential components for intercellular communication, bioactive cargo trafficking, and homeostasis maintenance. The knowledge regarding the diverse functions and applications of EVs has continually expanded over the recent decade. The classification of eukaryotic EVs based on their biophysical or … Read more