Journal of Leukocyte Biology

Eonisophil to Lymphocyte ratio and early variation as Predictors of Severity and in-hospital mortality in Patients Admitted to the Emergency Department for SARS-CoV-2 Infection​Pierre Godfrin on 18 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 18:qiaf105. doi: 10.1093/jleuko/qiaf105. Online ahead of print. ABSTRACT Since its emergence in 2019, the study of biomarkers in COVID-19 has focused on predicting the course of this potentially fatal disease. The eosinophil/lymphocyte ratio (ELR) appears to be a new indicator of systemic inflammation, morbidity, and mortality in inflammatory, allergic and … Read more

Adaptation of the living therapeutic materials concept to the immune sensing of neutrophil granulocytes​Islam Mohamed on 15 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 9;117(7):qiaf086. doi: 10.1093/jleuko/qiaf086. ABSTRACT Neutrophils are innate immune cells that perpetually patrol the circulation and tissues. They sense and migrate toward invading microbes to initiate and orchestrate a robust immune response. Their highly reactive nature, driven by multiple and redundant receptor families recognizing bacterial components, makes them particularly sensitive to … Read more

Human Neutrophils are a Cellular Source of Apolipoprotein A-I​Xianglan Yao on 14 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 14:qiaf104. doi: 10.1093/jleuko/qiaf104. Online ahead of print. ABSTRACT Apolipoprotein A-I (APOA1), the major protein of high-density lipoproteins, has anti-inflammatory functions. APOA1 is primarily produced in the liver, however, it is not known whether neutrophils are a cellular source. Here, we assessed whether human neutrophils express APOA1. Peripheral blood and bronchoalveolar … Read more

The role of tumor-associated neutrophils in the pathogenesis of recurrent respiratory papillomatosis​Yang Xiao on 14 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 9;117(7):qiaf055. doi: 10.1093/jleuko/qiaf055. ABSTRACT Neutrophils are known to infiltrate various tumor tissues extensively and contribute to disease progression. However, the role of tumor-associated neutrophils in the pathogenesis of recurrent respiratory papillomatosis remains unclear. This study aimed to explore the prognostic significance of tumor-associated neutrophils and examine their role in the … Read more

FAP on human NK cells: insights from NK cell activation and crosstalk with cancer-associated fibroblasts​Yentl Van Rymenant on 10 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 10:qiaf103. doi: 10.1093/jleuko/qiaf103. Online ahead of print. ABSTRACT Fibroblast activation protein alpha (FAP) is a post-prolyl proteolytic enzyme highly expressed in the tumor microenvironment (TME), particularly in cancer-associated fibroblasts (CAFs). Although previously thought to be restricted to CAFs, malignant cells and pathological fibroblasts, recent studies have identified FAP expression in … Read more

Potential functions of TRPM2 and TRPM7 channels in the tumor microenvironment​Irma Yadira Izaguirre-Hernández on 9 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 9:qiaf098. doi: 10.1093/jleuko/qiaf098. Online ahead of print. ABSTRACT The tumor microenvironment (TME) is a complex and dynamic ecosystem consisting of both cellular and non-cellular components that collectively modulate the anti-tumor immune response, as well as cancer growth, invasion, metastasis, immune evasion, and resistance to therapy. Calcium (Ca2+) and magnesium (Mg2+) … Read more

Macrophage IL-4 polarization is restricted by soluble CD40 agonists and antigen-induced CD154 but not by constitutive CD154 expressed by CD4+ T cells​Mariana Suárez-Martins on 9 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 9;117(7):qiaf069. doi: 10.1093/jleuko/qiaf069. ABSTRACT Stimulation of macrophages via CD40 promotes their classical activation. Therefore, CD154 (CD40 ligand) can be expected to oppose macrophage polarization and proliferation induced by IL-4. However, there are limited experimental data to support this, which is additionally complicated by the possibility of differential effects of CD40 … Read more

Transcriptional programs underlying human monocyte differentiation and diversity​Ravi K Komaravolu on 9 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 9;117(7):qiaf058. doi: 10.1093/jleuko/qiaf058. ABSTRACT Classical monocytes (CD14hiCD16-) differentiate into intermediate monocytes (CD14+CD16+), which in turn yield nonclassical monocytes (CD14-CD16hi). To investigate the transcriptional regulation underlying this differentiation or conversion, we analyzed 3 single-cell RNA-sequencing datasets of peripheral mononuclear blood cells from healthy individuals using the single-cell regulatory network inference and … Read more

Myeloid-specific deficiency of ribosomal protein L13a alters macrophage polarity and diversity during differentiation from bone marrow​Antara Roy on 9 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 9:qiaf102. doi: 10.1093/jleuko/qiaf102. Online ahead of print. ABSTRACT Macrophages show substantial plasticity, leading to a diverse population of these cells with different states of polarization during differentiation from bone marrow. However, the mechanisms underlying this process are not well understood. Here, we identified a novel role of ribosomal protein L13a … Read more

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