J Leukoc Biol. 2025 Nov 29:qiaf170. doi: 10.1093/jleuko/qiaf170. Online ahead of print. ABSTRACT Macrophage migration inhibitory factor (MIF) is broadly produced by various cell types, particularly immune cells, and functions as a key modulator of innate and adaptive immunity. Increasing evidence has linked MIF to the pathogenesis of both solid tumors and hematologic malignancies, including … Read more

J Leukoc Biol. 2025 Nov 28:qiaf168. doi: 10.1093/jleuko/qiaf168. Online ahead of print. ABSTRACT Monocytes play a fundamental role in the inflammatory response to diverse stimuli. A critical early step in the initiation of this response is the recruitment of monocytes from the bloodstream to sites of tissue injury. This migration is tightly regulated at the … Read more

J Leukoc Biol. 2025 Nov 4;117(11):qiaf149. doi: 10.1093/jleuko/qiaf149. NO ABSTRACT PMID:41296542 | DOI:10.1093/jleuko/qiaf149

J Leukoc Biol. 2025 Nov 4;117(11):qiaf152. doi: 10.1093/jleuko/qiaf152. ABSTRACT Sepsis is a life-threatening condition driven by a dysregulated host response to infection, in which the innate immune axis-particularly the crosstalk between neutrophils and macrophages-plays a central role in dictating disease trajectory. This review delineates the functional, metabolic, and spatial characteristics of these two phagocytic cell … Read more

J Leukoc Biol. 2025 Nov 20:qiaf167. doi: 10.1093/jleuko/qiaf167. Online ahead of print. ABSTRACT IRGM proteins are associated with increased susceptibility to Crohn’s disease, mycobacterial infections, sepsis, and other inflammatory diseases, but the cells in which they function in vivo have not been delineated. To address this, mice with conditional deletions of Irgm1 were created and … Read more

J Leukoc Biol. 2025 Nov 4;117(11):qiaf138. doi: 10.1093/jleuko/qiaf138. ABSTRACT Natural killer (NK) cells are the first line of defense against viral infections and tumors. Their cytotoxic activity relies on the formation of an immune synapse (IS) with target cells. The lymphocyte function-associated antigen (LFA)-1 plays a central role in NK cell cytotoxicity by modulating NK-IS … Read more

J Leukoc Biol. 2025 Nov 17:qiaf165. doi: 10.1093/jleuko/qiaf165. Online ahead of print. ABSTRACT Patients who survive sepsis experience a prolonged period of immunosuppression. This period is accompanied by the expansion of monocytic myeloid-derived suppressor cells (M-MDSCs), a subset of suppressive myeloid cells; however, the impact of M-MDSCs on the innate immune response to infection is … Read more

J Leukoc Biol. 2025 Nov 17:qiaf166. doi: 10.1093/jleuko/qiaf166. Online ahead of print. ABSTRACT Gamma-aminobutyric acid (GABA), a non-protein component amino acid, functions as an inhibitory neurotransmitter. Here, we showed that GABA levels are significantly elevated in the bone marrow (BM) liquid of patients with multiple myeloma (MM) compared to healthy donors (HDs). Moreover, BM GABA … Read more

J Leukoc Biol. 2025 Nov 14:qiaf164. doi: 10.1093/jleuko/qiaf164. Online ahead of print. ABSTRACT Following the 2025 Nobel Prize in Physiology or Medicine for the discovery of regulatory T cells (Tregs), a recent article in Nature Communications reports the creation of allogeneic, genome-edited Tregs engineered to evade immune rejection while retaining suppressive function. Through non-viral CRISPR … Read more

J Leukoc Biol. 2025 Nov 13:qiaf163. doi: 10.1093/jleuko/qiaf163. Online ahead of print. ABSTRACT Mycoplasma pneumoniae (Mp) is a frequent cause of pediatric pneumonia, largely due to the challenges in early detection and the tendency to underestimate the severity of infections. Emerging evidence suggests that ATP-binding cassette transporter G1 (ABCG1) plays a critical role in preventing … Read more