Journal of Leukocyte Biology

J Leukoc Biol. 2025 Aug 11:qiaf119. doi: 10.1093/jleuko/qiaf119. Online ahead of print. ABSTRACT Platelets release microvesicles (PMVs) into the extracellular milieu upon activation. PMVs retain various platelet components, including functional mitochondria, and actively participate in intercellular communication with immune cells such as polymorphonuclear leukocytes (PMN). PMVs have been known to modulate the inflammatory response of … Read more

J Leukoc Biol. 2025 Aug 12:qiaf116. doi: 10.1093/jleuko/qiaf116. Online ahead of print. ABSTRACT Inflammatory bowel disease (IBD) is a debilitating and symptomatic disorder of the gastrointestinal tract, featuring dysregulated inflammation, intestinal injury and barrier dysfunction. IBD is also a risk factor for colorectal cancer (CRC), which remains a leading cause of cancer-related mortalities worldwide. Matrix … Read more

J Leukoc Biol. 2025 Aug 7:qiaf118. doi: 10.1093/jleuko/qiaf118. Online ahead of print. ABSTRACT Pediatric sepsis has constantly increased over the world, and is now a leading cause of children morbidity and mortality. Due to this alarming trend, intense research has been sparked into the unique characteristics of pediatric sepsis, the mechanisms behind the immune dysfunction, … Read more

J Leukoc Biol. 2025 Aug 5:qiaf117. doi: 10.1093/jleuko/qiaf117. Online ahead of print. ABSTRACT Immune function alters as we age, and is often accompanied by chronic, low-grade inflammation termed inflammageing. This leads cells to develop a senescence-associated secretory phenotype (SASP) and release a range of pro-inflammatory cytokines and proteolytic enzymes. In individuals with frailty, inflammaging and … Read more

J Leukoc Biol. 2025 Aug 5;117(8):qiaf089. doi: 10.1093/jleuko/qiaf089. ABSTRACT Cyclophilin A (CypA) is a member of the isomerase family; in the secreted form, it acts as a chemoattractant and pro-inflammatory factor, orchestrating the development of the local inflammatory response. In this work, we studied the role of secreted CypA in regulating an adaptive immune response. … Read more

J Leukoc Biol. 2025 Aug 7:qiaf114. doi: 10.1093/jleuko/qiaf114. Online ahead of print. ABSTRACT Macrophages have a dual role in tissue healing after injury as they perform tissue repair functions but can also precipitate tissue damage or promote fibrosis. Platelets, beyond their role in thrombosis and hemostasis, are crucial mediators of inflammation and interact with macrophages. … Read more

J Leukoc Biol. 2025 Aug 7:qiaf109. doi: 10.1093/jleuko/qiaf109. Online ahead of print. ABSTRACT The ejection of neutrophil extracellular trap (NET) is one of the characteristic features of neutrophils. Rapid release of NET-containing extracellular vesicles (NET-EVs) to the extracellular space has been reported as a novel NET-release mechanism in response to Staphylococcus aureus. An increased number … Read more

J Leukoc Biol. 2025 Aug 1:qiaf113. doi: 10.1093/jleuko/qiaf113. Online ahead of print. ABSTRACT Neutrophils are essential components of the innate immune system, playing a critical role in responding to infections and inflammation. Their recruitment from blood circulation to affected tissues follows a well-coordinated multistep adhesion and activation cascade. Recent studies highlight the importance of posttranslational … Read more

J Leukoc Biol. 2025 Jul 31:qiaf111. doi: 10.1093/jleuko/qiaf111. Online ahead of print. ABSTRACT Morphologic studies show increased mast cell activation during T cell-mediated inflammation. Previous research demonstrated that microvesicles from activated T cells (MVT*), but not resting T cells (MVT), stimulate human mast cells via the MAPK pathway, leading to degranulation and cytokine release. This … Read more

J Leukoc Biol. 2025 Jul 31:qiaf110. doi: 10.1093/jleuko/qiaf110. Online ahead of print. ABSTRACT Psoriasis is a systemic inflammatory skin disorder with a prevalence of 2 % in adults. Up to 30 % of affected individuals further develop psoriatic arthritis (PsA), which is characterized by additional joint inflammation. Myeloperoxidase (MPO) is strongly expressed by neutrophils and, … Read more