Neutrophil CD300ld: A savior of organ failure?Duane Jeansonne on 4 de July de 2025 at 10:00
J Leukoc Biol. 2025 Jul 4:qiaf101. doi: 10.1093/jleuko/qiaf101. Online ahead of print. NO ABSTRACT PMID:40611662 | DOI:10.1093/jleuko/qiaf101
Journal of Leukocyte Biology
Treponema pallidum lipoprotein TpF1 regulates METTL14-mediated NF-κB signaling pathway to promote macrophage M2 polarizationQian Cao on 3 de July de 2025 at 10:00
J Leukoc Biol. 2025 Jul 3:qiaf099. doi: 10.1093/jleuko/qiaf099. Online ahead of print. ABSTRACT During Treponema pallidum(T.pallidum) infection, m6A modification negatively regulates inflammatory responses in macrophages. However, whether m6A modification participates in the regulation of macrophage M2 polarization during T.pallidum infection remains unclear. Using THP-1-derived macrophages as a model, this study investigated the mechanism by which … Read more
Resolution of Innate Immune Cells with Pro-Resolving Lipid Mediators in Idiopathic Pulmonary FibrosisYuet Ang on 3 de July de 2025 at 10:00
J Leukoc Biol. 2025 Jul 3:qiaf100. doi: 10.1093/jleuko/qiaf100. Online ahead of print. ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a progressive incurable lung disease characterized by chronic inflammation and fibrosis, with innate immune cells such as neutrophils and macrophages playing central roles in its pathogenesis. This review explores the involvement of these immune cells in the … Read more
Alpha-1 antitrypsin modulates neutrophil phenotype and function: implications for inflammatory regulationRegina Oshins on 1 de July de 2025 at 10:00
J Leukoc Biol. 2025 Jun 4;117(6):qiaf091. doi: 10.1093/jleuko/qiaf091. ABSTRACT Alpha-1 antitrypsin, the most abundant protease inhibitor within the plasma, plays a crucial role in regulating neutrophils’ function during inflammation. Alpha-1 antitrypsin deficiency is associated with excessive neutrophilic inflammation, yet the mechanisms underlying alpha-1 antitrypsin’s role in neutrophil trafficking remain poorly understood. Here, we demonstrate alpha-1 … Read more
Complexity of the neutrophil transcriptome in early and severe rheumatoid arthritis: a role for microRNAs?Michele Fresneda Alarcon on 1 de July de 2025 at 10:00
J Leukoc Biol. 2025 Jun 4;117(6):qiaf090. doi: 10.1093/jleuko/qiaf090. ABSTRACT Neutrophils are innate immune cells that drive the progression of rheumatoid arthritis through the release of reactive oxygen species, neutrophil extracellular traps, and proteases that damage host tissues. Neutrophil activation is regulated, in part, by dynamic changes in gene expression. In this study, we have used … Read more
Early increased monocyte-to-lymphocyte ratio as a potential biomarker of bacterial sepsis in patients with severe COVID-19Edna Basilio-Gálvez on 1 de July de 2025 at 10:00
J Leukoc Biol. 2025 Jun 4;117(6):qiaf064. doi: 10.1093/jleuko/qiaf064. ABSTRACT Monocytes are pivotal during inflammation. Sepsis added to COVID-19 increases mortality and inflammation. However, the role of monocytes in this condition is unclear. Our aim was to determine monocyte frequencies and HLA-DR expression related to size distribution in patients with severe COVID-19 with or without sepsis. … Read more
Early increased monocyte-to-lymphocyte ratio as a potential biomarker of bacterial sepsis in patients with severe COVID-19Edna Basilio-Gálvez on 1 de July de 2025 at 10:00
J Leukoc Biol. 2025 Jun 4;117(6):qiaf064. doi: 10.1093/jleuko/qiaf064. ABSTRACT Monocytes are pivotal during inflammation. Sepsis added to COVID-19 increases mortality and inflammation. However, the role of monocytes in this condition is unclear. Our aim was to determine monocyte frequencies and HLA-DR expression related to size distribution in patients with severe COVID-19 with or without sepsis. … Read more
Berbamine promotes autophagy and GPX4 expression through inducing abundant ROS to restrict HIV-1 and Mtb coinfection in macrophagesXuefeng Zhou on 28 de June de 2025 at 10:00
J Leukoc Biol. 2025 Jun 23:qiaf095. doi: 10.1093/jleuko/qiaf095. Online ahead of print. ABSTRACT Human immunodeficiency virus type 1 (HIV-1) and Mycobacterium tuberculosis (Mtb) co-infection poses a significant public health threat, characterized by a high mortality rate due to impaired host immune responses. In this study, we investigated the role of autophagy, primarily using macrophage cell … Read more
The Universal Receptive System: A Novel Regulator of Antimicrobial and Anticancer Compound Production by White Blood CellsVictor Tetz on 27 de June de 2025 at 10:00
J Leukoc Biol. 2025 Jun 20:qiaf085. doi: 10.1093/jleuko/qiaf085. Online ahead of print. ABSTRACT Despite recent advances, the regulation of anticancer and antimicrobial bioactive compound (AABC) production by leukocytes remains poorly understood. Here, we demonstrate that inactivation of the DNA- and RNA-based Teazeled receptors of the Universal Receptive System in human leukocytes generated so called “Leukocyte-Tells,” … Read more
KMT2D upregulates SMG1 via histone methylation to antagonize mTOR and reinforce DLBCL ferroptosisYongcheng Sun on 27 de June de 2025 at 10:00
J Leukoc Biol. 2025 Jun 19:qiaf092. doi: 10.1093/jleuko/qiaf092. Online ahead of print. ABSTRACT Diffuse large B-cell lymphoma (DLBCL) is highly heterogeneous and prone to epigenetic mutations. Non-apoptotic cell death pathways, especially ferroptosis, have become an emerging direction for cancer treatment. This project was designed to probe into the potential of histone-lysine N-methyltransferase 2D (KMT2D) in … Read more