Journal of Leukocyte Biology

J Leukoc Biol. 2025 Oct 22:qiaf148. doi: 10.1093/jleuko/qiaf148. Online ahead of print. ABSTRACT Neutrophils, the most abundant leukocytes in humans, exhibit significant differences from their murine counterparts, shaping immune responses and disease outcomes. Recent studies indicate that fungal exposure in rewilded mice modifies neutrophil development, aligning it more closely with human neutrophil characteristics and emphasizing … Read more

J Leukoc Biol. 2025 Oct 21:qiaf147. doi: 10.1093/jleuko/qiaf147. Online ahead of print. ABSTRACT Assembly of NADPH oxidase 2 (NOX2) proteins in neutrophils plays an essential role in controlling microbial infections by producing high levels of reactive oxygen species (ROS). We reported that neutrophils and NOX2 are required to control P. aeruginosa in a clinically relevant … Read more

J Leukoc Biol. 2025 Oct 17:qiaf145. doi: 10.1093/jleuko/qiaf145. Online ahead of print. ABSTRACT Myeloid cells- including monocytes, macrophages, dendritic cells (DCs), and granulocytes constitute a versatile arm of the immune system, serving as frontline sentinels that detect and react to environmental cues and orchestrate tailored immune responses. Their ability to respond promptly to distinct threats … Read more

J Leukoc Biol. 2025 Oct 14:qiaf144. doi: 10.1093/jleuko/qiaf144. Online ahead of print. ABSTRACT Metabolic remodeling is involved in multiple diseases, including tumors, acute and chronic inflammations, but our understanding of the molecular pathways remains limited. Neutrophils, as pivotal effector cells of the innate immune system, exhibit significant functional heterogeneity influenced by the hypoxic microenvironment, a … Read more

J Leukoc Biol. 2025 Oct 10:qiaf139. doi: 10.1093/jleuko/qiaf139. Online ahead of print. ABSTRACT Acute lymphoblastic leukemia (ALL) is a hematological malignancy characterized by the uncontrolled proliferation of immature lymphoid cells, but the role of circNR3C1 in ALL is not fully elucidated. In this study, expression levels of circNR3C1, RPS3, ENO1, and MSI2 were assessed in … Read more

J Leukoc Biol. 2025 Oct 10:qiaf143. doi: 10.1093/jleuko/qiaf143. Online ahead of print. ABSTRACT Adoptive cell therapy using ex vivo expanded autologous Tregs could be a novel therapeutic approach for cell-based immunotherapy in dogs. This study aimed to expand dog Treg lymphocytes via the use of tregitopes. PBMCs were isolated from healthy beagle dogs and stimulated … Read more

J Leukoc Biol. 2025 Oct 9:qiaf142. doi: 10.1093/jleuko/qiaf142. Online ahead of print. ABSTRACT Neutrophils are central to immune responses in health and disease, and their ability to deform correlates with their functional responses. In health, reorganisation of the neutrophil cytoskeleton allows neutrophils to carry out their effector mechanisms. However, in the disease state, dysregulation of … Read more

J Leukoc Biol. 2025 Oct 7:qiaf141. doi: 10.1093/jleuko/qiaf141. Online ahead of print. ABSTRACT Regulatory B cells (Bregs), specifically the CD24⁺CD38⁺ phenotype, are known for their capacity to reduce inflammation by releasing interleukin 10(IL-10). However, their potential role in regulating inflammation through macrophage differentiation is not well understood. This study investigates how CD24⁺CD38⁺ regulatory B cells … Read more

J Leukoc Biol. 2025 Oct 7:qiaf140. doi: 10.1093/jleuko/qiaf140. Online ahead of print. ABSTRACT Toll-like receptor (TLR) signaling is vital for antimicrobial macrophage function, and its dysregulation is associated with diseases such as lupus, multiple sclerosis, pulmonary fibrosis, and cancer. The Src-family kinase Lyn may have net activating or inhibitory effects on TLR signaling, yet distinct … Read more

J Leukoc Biol. 2025 Oct 1;117(10):qiaf062. doi: 10.1093/jleuko/qiaf062. ABSTRACT The monocyte-to-macrophage transition is marked by alterations to both the structure and function of the genome, including changes in histone posttranslational modifications, DNA methylation, 3D nuclear architecture, and expression of lineage specific genes. The nucleosome is the fundamental organizational unit of the eukaryotic genome and underpins … Read more