Journal of Leukocyte Biology

Mechanisms of Immune Suppression in Sepsis/Shock: One investigator’s/lab group’s experience (SLB 2024 Legacy Award Presentation)​Alfred Ayala on 24 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 24:qiaf108. doi: 10.1093/jleuko/qiaf108. Online ahead of print. ABSTRACT When I think about scientific/professional “legacy”, for me there are at least 3 areas to consider: 1) the actual scientific legacy you (and your lab members) have contributed to; 2) the people you have touched and how they touch you in this … Read more

An IL-15-modified NKp30×HER2 trispecific NK cell engager enhances NK cell activation and tumor cell killing​Yaping Cheng on 22 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 22:qiaf107. doi: 10.1093/jleuko/qiaf107. Online ahead of print. ABSTRACT Natural killer (NK) cells represent a promising effector population for tumor immunotherapy. Conventional NK cell engagers (NKCEs), primarily targeting CD16a, show efficacy but face limitations due to receptor polymorphisms and off-target toxicity. Here, we report the development and characterization of a novel … Read more

Decreased HLA-DR+CD3+ T cells three months after allogeneic stem cell transplantation predict severe chronic GvHD and transplant-related mortality​Stefan Koeck on 22 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 22:qiaf106. doi: 10.1093/jleuko/qiaf106. Online ahead of print. ABSTRACT Chronic Graft versus Host Disease (cGvHD) is a major late determinant of transplant related mortality (TRM) after allogeneic stem cell transplantation (HSCT). We investigated the predictive value of peripheral blood activated HLA-DR+CD3+ T cells as a novel biomarker. In total, 107 patients … Read more

Eonisophil to Lymphocyte ratio and early variation as Predictors of Severity and in-hospital mortality in Patients Admitted to the Emergency Department for SARS-CoV-2 Infection​Pierre Godfrin on 18 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 18:qiaf105. doi: 10.1093/jleuko/qiaf105. Online ahead of print. ABSTRACT Since its emergence in 2019, the study of biomarkers in COVID-19 has focused on predicting the course of this potentially fatal disease. The eosinophil/lymphocyte ratio (ELR) appears to be a new indicator of systemic inflammation, morbidity, and mortality in inflammatory, allergic and … Read more

Adaptation of the living therapeutic materials concept to the immune sensing of neutrophil granulocytes​Islam Mohamed on 15 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 9;117(7):qiaf086. doi: 10.1093/jleuko/qiaf086. ABSTRACT Neutrophils are innate immune cells that perpetually patrol the circulation and tissues. They sense and migrate toward invading microbes to initiate and orchestrate a robust immune response. Their highly reactive nature, driven by multiple and redundant receptor families recognizing bacterial components, makes them particularly sensitive to … Read more

Human Neutrophils are a Cellular Source of Apolipoprotein A-I​Xianglan Yao on 14 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 14:qiaf104. doi: 10.1093/jleuko/qiaf104. Online ahead of print. ABSTRACT Apolipoprotein A-I (APOA1), the major protein of high-density lipoproteins, has anti-inflammatory functions. APOA1 is primarily produced in the liver, however, it is not known whether neutrophils are a cellular source. Here, we assessed whether human neutrophils express APOA1. Peripheral blood and bronchoalveolar … Read more

The role of tumor-associated neutrophils in the pathogenesis of recurrent respiratory papillomatosis​Yang Xiao on 14 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 9;117(7):qiaf055. doi: 10.1093/jleuko/qiaf055. ABSTRACT Neutrophils are known to infiltrate various tumor tissues extensively and contribute to disease progression. However, the role of tumor-associated neutrophils in the pathogenesis of recurrent respiratory papillomatosis remains unclear. This study aimed to explore the prognostic significance of tumor-associated neutrophils and examine their role in the … Read more

FAP on human NK cells: insights from NK cell activation and crosstalk with cancer-associated fibroblasts​Yentl Van Rymenant on 10 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 10:qiaf103. doi: 10.1093/jleuko/qiaf103. Online ahead of print. ABSTRACT Fibroblast activation protein alpha (FAP) is a post-prolyl proteolytic enzyme highly expressed in the tumor microenvironment (TME), particularly in cancer-associated fibroblasts (CAFs). Although previously thought to be restricted to CAFs, malignant cells and pathological fibroblasts, recent studies have identified FAP expression in … Read more

Potential functions of TRPM2 and TRPM7 channels in the tumor microenvironment​Irma Yadira Izaguirre-Hernández on 9 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 9:qiaf098. doi: 10.1093/jleuko/qiaf098. Online ahead of print. ABSTRACT The tumor microenvironment (TME) is a complex and dynamic ecosystem consisting of both cellular and non-cellular components that collectively modulate the anti-tumor immune response, as well as cancer growth, invasion, metastasis, immune evasion, and resistance to therapy. Calcium (Ca2+) and magnesium (Mg2+) … Read more

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