Journal of Leukocyte Biology

Dynamic nucleosome redistribution and increases in nucleosome sensitivity underpin THP-1 macrophage response to LPS​Jane M Benoit on 1 de October de 2025 at 10:00

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J Leukoc Biol. 2025 Oct 1;117(10):qiaf067. doi: 10.1093/jleuko/qiaf067. ABSTRACT Macrophages detect lipopolysaccharide (LPS) through toll-like receptor 4 (TLR-4) on the cell surface which initiates a signaling cascade, resulting in the recruitment of regulatory factors to chromatin and subsequent expression of chemokine and cytokine genes. Primary response genes, marked by poised promoters and enhancers, are rapidly … Read more

Tissue damage, myocardial injury and recruitment of mature and banded neutrophils after high-intensity endurance exercise​Bernard N Jukema on 30 de September de 2025 at 10:00

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J Leukoc Biol. 2025 Sep 30:qiaf137. doi: 10.1093/jleuko/qiaf137. Online ahead of print. ABSTRACT Neutrophils are key players in inflammatory responses that are modulated by cytokines/chemokines and damage associated molecular patterns (DAMPs). Exercise induces acute neutrophilia, but little is known regarding recruitment of neutrophil subsets (banded (CD16dim/CD62Lbright) and hypersegmented (CD16bright/CD62Ldim) cells) and it’s relation with the … Read more

Metformin improves CD8+ T cell responses and parasitemia control via macrophage modulation during Trypanosoma cruzi infection​Ruth Eliana Baigorri on 26 de September de 2025 at 10:00

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J Leukoc Biol. 2025 Sep 26:qiaf134. doi: 10.1093/jleuko/qiaf134. Online ahead of print. ABSTRACT The immune response to Trypanosoma cruzi infection relies on robust inflammatory activation of macrophages and proper CD8+ T cells function to control parasite replication. However, an exacerbated respiratory burst from macrophages can damage tissues where parasites reside, such as the heart and … Read more

Resolved versus uncontrolled inflammation: a mathematical model to decipher the role of innate immunity​Karina García-Martínez on 26 de September de 2025 at 10:00

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J Leukoc Biol. 2025 Sep 26:qiaf132. doi: 10.1093/jleuko/qiaf132. Online ahead of print. ABSTRACT Understanding the impact of Neutrophils and Macrophages in the dynamic outcome of resolution vs uncontrolled response is still an open debate. Here, we develop a mathematical model that describe the dynamic of the innate immune response after an acute damage. Our model … Read more

GATA2 Induces a Stem Cell-Like Transcriptional Program in Macrophages That Promotes an Atherogenic Phenotype​Amena Aktar on 25 de September de 2025 at 10:00

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J Leukoc Biol. 2025 Sep 25:qiaf136. doi: 10.1093/jleuko/qiaf136. Online ahead of print. ABSTRACT Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipid-laden necrotic macrophages within blood vessels walls. GATA2 is a normally hematopoietic transcription factor which in the bone marrow helps maintain the proliferative, non-differentiated phenotype of hematopoietic progenitors. Unexpectedly, GATA2 is … Read more

Low density granulocytes in the pathogenesis of inflammatory disease​Abigail S Nutley on 25 de September de 2025 at 10:00

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J Leukoc Biol. 2025 Sep 25:qiaf133. doi: 10.1093/jleuko/qiaf133. Online ahead of print. ABSTRACT Low density granulocytes (LDG) are a population of predominantly neutrophils that sit within the peripheral blood mononuclear cell layer following density centrifugation. Their presence in various inflammatory conditions raises the question of their role in disease pathogenesis. LDG may be a heterogeneous … Read more

Transcriptome-wide Mendelian randomization exploring dynamic CD4+ T cell gene expression in colorectal cancer development​Benedita Deslandes on 20 de September de 2025 at 10:00

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J Leukoc Biol. 2025 Sep 17:qiaf131. doi: 10.1093/jleuko/qiaf131. Online ahead of print. ABSTRACT Recent research suggests higher circulating lymphocyte counts may protect against colorectal cancer (CRC). However, the role of specific lymphocyte subtypes and activation states remain unclear. CD4+ T cells – a highly dynamic lymphocyte subtype – undergo gene expression changes upon activation that … Read more

Harnessing scRNA-seq and bulk RNA-seq to identify CD39+T cell genes for rheumatoid arthritis diagnosis and therapy​Dandan Yun on 20 de September de 2025 at 10:00

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J Leukoc Biol. 2025 Sep 17:qiaf130. doi: 10.1093/jleuko/qiaf130. Online ahead of print. ABSTRACT Rheumatoid arthritis (RA) is a prevalent autoimmune disorder with an elusive pathogenesis, hindering early detection and therapeutic advancements. This study focuses on CD39+ T cells, which play a significant role in RA, to identify diagnostic and therapeutic biomarkers. We analyzed scRNA-seq data … Read more

S100A9 promotes inflammasome-dependent autoinflammation by blocking the degradation of SYK tyrosine kinase​Jonas Wolf on 18 de September de 2025 at 10:00

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J Leukoc Biol. 2025 Sep 12:qiaf129. doi: 10.1093/jleuko/qiaf129. Online ahead of print. ABSTRACT Autoinflammatory diseases such as CAPS (Cryopyrin-Associated Periodic Fever Syndrome) and FMF (Familial Mediterranean Fever) involve an aberrant secretion of interleukin-1β (IL-1β) due to genetic defects in the NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) or pyrin inflammasomes. The regulatory mechanisms and … Read more

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