Journal of Leukocyte Biology

J Leukoc Biol. 2025 Jul 9;117(7):qiaf069. doi: 10.1093/jleuko/qiaf069. ABSTRACT Stimulation of macrophages via CD40 promotes their classical activation. Therefore, CD154 (CD40 ligand) can be expected to oppose macrophage polarization and proliferation induced by IL-4. However, there are limited experimental data to support this, which is additionally complicated by the possibility of differential effects of CD40 … Read more

J Leukoc Biol. 2025 Jul 9;117(7):qiaf058. doi: 10.1093/jleuko/qiaf058. ABSTRACT Classical monocytes (CD14hiCD16-) differentiate into intermediate monocytes (CD14+CD16+), which in turn yield nonclassical monocytes (CD14-CD16hi). To investigate the transcriptional regulation underlying this differentiation or conversion, we analyzed 3 single-cell RNA-sequencing datasets of peripheral mononuclear blood cells from healthy individuals using the single-cell regulatory network inference and … Read more

J Leukoc Biol. 2025 Jul 9:qiaf102. doi: 10.1093/jleuko/qiaf102. Online ahead of print. ABSTRACT Macrophages show substantial plasticity, leading to a diverse population of these cells with different states of polarization during differentiation from bone marrow. However, the mechanisms underlying this process are not well understood. Here, we identified a novel role of ribosomal protein L13a … Read more

J Leukoc Biol. 2025 Jul 4:qiaf101. doi: 10.1093/jleuko/qiaf101. Online ahead of print. NO ABSTRACT PMID:40611662 | DOI:10.1093/jleuko/qiaf101

J Leukoc Biol. 2025 Jul 3:qiaf099. doi: 10.1093/jleuko/qiaf099. Online ahead of print. ABSTRACT During Treponema pallidum(T.pallidum) infection, m6A modification negatively regulates inflammatory responses in macrophages. However, whether m6A modification participates in the regulation of macrophage M2 polarization during T.pallidum infection remains unclear. Using THP-1-derived macrophages as a model, this study investigated the mechanism by which … Read more

J Leukoc Biol. 2025 Jul 3:qiaf100. doi: 10.1093/jleuko/qiaf100. Online ahead of print. ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a progressive incurable lung disease characterized by chronic inflammation and fibrosis, with innate immune cells such as neutrophils and macrophages playing central roles in its pathogenesis. This review explores the involvement of these immune cells in the … Read more

J Leukoc Biol. 2025 Jun 4;117(6):qiaf091. doi: 10.1093/jleuko/qiaf091. ABSTRACT Alpha-1 antitrypsin, the most abundant protease inhibitor within the plasma, plays a crucial role in regulating neutrophils’ function during inflammation. Alpha-1 antitrypsin deficiency is associated with excessive neutrophilic inflammation, yet the mechanisms underlying alpha-1 antitrypsin’s role in neutrophil trafficking remain poorly understood. Here, we demonstrate alpha-1 … Read more

J Leukoc Biol. 2025 Jun 4;117(6):qiaf090. doi: 10.1093/jleuko/qiaf090. ABSTRACT Neutrophils are innate immune cells that drive the progression of rheumatoid arthritis through the release of reactive oxygen species, neutrophil extracellular traps, and proteases that damage host tissues. Neutrophil activation is regulated, in part, by dynamic changes in gene expression. In this study, we have used … Read more

J Leukoc Biol. 2025 Jun 4;117(6):qiaf064. doi: 10.1093/jleuko/qiaf064. ABSTRACT Monocytes are pivotal during inflammation. Sepsis added to COVID-19 increases mortality and inflammation. However, the role of monocytes in this condition is unclear. Our aim was to determine monocyte frequencies and HLA-DR expression related to size distribution in patients with severe COVID-19 with or without sepsis. … Read more

J Leukoc Biol. 2025 Jun 4;117(6):qiaf064. doi: 10.1093/jleuko/qiaf064. ABSTRACT Monocytes are pivotal during inflammation. Sepsis added to COVID-19 increases mortality and inflammation. However, the role of monocytes in this condition is unclear. Our aim was to determine monocyte frequencies and HLA-DR expression related to size distribution in patients with severe COVID-19 with or without sepsis. … Read more