Journal of Leukocyte Biology

J Leukoc Biol. 2025 May 24:qiaf073. doi: 10.1093/jleuko/qiaf073. Online ahead of print. ABSTRACT Immune-mediated bone marrow failure (BMF) entails a complex immune landscape. Myeloid cells, including monocytes, macrophages, and myeloid-derived suppressor cells (MDSCs), are involved in the development and progression of immune aplastic anemia (AA). We used a murine model of BMF to explore the … Read more

J Leukoc Biol. 2025 May 7;117(5):qiaf035. doi: 10.1093/jleuko/qiaf035. ABSTRACT In the early COVID-19 pandemic, the strain on healthcare facilities highlighted the need for reliable biomarkers to predict progression to severe COVID-19. Neutrophils, the most abundant leukocytes in circulation, are early defenders against pathogens. In a Singaporean adult cohort, early neutrophil mediators were assessed for their … Read more

J Leukoc Biol. 2025 May 22:qiaf072. doi: 10.1093/jleuko/qiaf072. Online ahead of print. ABSTRACT Increasing numbers of clinical cohorts have detected CCND2 mutations in acute myeloid leukemia (AML), especially in the subtype of AML with t(8;21) translocation. As known, this AML subtype is characterized by the formation of AML1-ETO fusion gene. However, AML1-ETO fusion gene alone … Read more

J Leukoc Biol. 2025 May 22:qiaf071. doi: 10.1093/jleuko/qiaf071. Online ahead of print. ABSTRACT Macrophages are central to innate immunity and are routinely used in vitro to examine molecular mechanisms contributing to innate immune signaling. However, there is a lack of consensus within the field for optimal in vitro culturing methods, and it is not well … Read more

J Leukoc Biol. 2025 May 7;117(5):qiaf036. doi: 10.1093/jleuko/qiaf036. ABSTRACT Excessive activation of toll-like receptor 7 and 8 (TLR7/8) plays a role in the pathogenesis of autoimmune diseases and is associated with negative outcomes from viral infections. Neutrophil activation is highly inflammatory and mediates tissue damage. We explored the effects of TLR7/8 activation in neutrophils to … Read more

J Leukoc Biol. 2025 May 21:qiaf070. doi: 10.1093/jleuko/qiaf070. Online ahead of print. ABSTRACT Psoriasis is a persistent immune-mediated inflammatory dermatosis. The treatment of psoriasis now features natural medicine as an effective new alternative because of its notable effectiveness and few side effects. Nervonic acid (NA), a long-chain fatty acid mostly sourced from the seed oils … Read more

J Leukoc Biol. 2025 May 7;117(5):qiaf046. doi: 10.1093/jleuko/qiaf046. NO ABSTRACT PMID:40391489 | DOI:10.1093/jleuko/qiaf046

J Leukoc Biol. 2025 May 20:qiaf066. doi: 10.1093/jleuko/qiaf066. Online ahead of print. ABSTRACT The immunosuppressive tumor microenvironment (TME) is a critical determinant of therapeutic resistance in colorectal cancer (CRC). The TME encompasses diverse cellular and stromal elements, including tumor cells, immune cells, extracellular matrix (ECM), and lymphatic vessels. Among these components, tumor-associated macrophages (TAMs) predominate … Read more

J Leukoc Biol. 2025 May 20:qiaf059. doi: 10.1093/jleuko/qiaf059. Online ahead of print. ABSTRACT The micro-RNA miR-125b-5p, recognized as a tumor suppressor, has demonstrated the ability to curb the proliferation of various types of cancer cells. Our latest research has revealed that miR-125b-5p also impedes the proliferation and functionality of CD4+Foxp3+ regulatory T cells (Tregs) by … Read more

J Leukoc Biol. 2025 May 19:qiaf057. doi: 10.1093/jleuko/qiaf057. Online ahead of print. ABSTRACT Optimal antimicrobial action of human neutrophils (PMN) relies on the synergy of oxidants and granule proteins, most notably that between the granule protein myeloperoxidase (MPO) and hydrogen peroxide (H2O2) to oxidize chloride anion to produce the potent microbicide, hypochlorous acid (HOCl). However, … Read more