Mucosal Immunology

The neuroendocrine peptide catestatin promotes clearance of cutaneous Staphylococcus aureus through mast cell Mrgpr activation. Colin Guth

6 de March de 2026 by inmunoadmin

Mucosal Immunol. 2026 Mar 3:S1933-0219(26)00027-9. doi: 10.1016/j.mucimm.2026.03.003. Online ahead of print. ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of cutaneous infections, underscoring the need for alternative therapeutic strategies. Catestatin (CST), a neuroendocrine antimicrobial peptide produced by neurons and epithelial cells, has been implicated in skin defense against pathogens such as MRSA, though its … Read more

Inhaled Acinetobacter lwoffii exposure promotes lung PD-L1+ neutrophils and dampens viral-induced type 2 immunity. Kunyuan Tian

2 de March de 2026 by inmunoadmin

Mucosal Immunol. 2026 Feb 27:S1933-0219(26)00024-3. doi: 10.1016/j.mucimm.2026.02.007. Online ahead of print. NO ABSTRACT PMID:41765103 | DOI:10.1016/j.mucimm.2026.02.007

Alveolar macrophages shape tuberculosis susceptibility by delaying protective immunity. Consuelo Micheli

24 de February de 2026 by inmunoadmin

Mucosal Immunol. 2026 Feb 21:S1933-0219(26)00023-1. doi: 10.1016/j.mucimm.2026.02.006. Online ahead of print. ABSTRACT EFFECTIVE control of Mycobacterium tuberculosis (Mtb) infection requires timely activation and accumulation of CD4+ T cells in the lungs, yet the factors delaying this response remain unclear. Here we show that alveolar macrophages (AMs) delay CD4+ T cell priming by retaining Mtb within … Read more

Interaction between airway basal cells, mast cells and type 2 immunity contributes to epithelial barrier dysfunction in allergic rhinitis. Emma Ruysseveldt

24 de February de 2026 by inmunoadmin

Mucosal Immunol. 2026 Feb 21:S1933-0219(26)00021-8. doi: 10.1016/j.mucimm.2026.02.004. Online ahead of print. ABSTRACT Basal cell dysfunction contributes to the pathophysiology of chronic inflammatory airway disorders and is linked to persistent epithelial barrier defects. Epithelial integrity dysfunction, basal cell hyperplasia and metaplasia have been described in allergic rhinitis (AR). However, it remains unclear how basal cell progenitor … Read more

Temporal Dissection of TGF-β signaling reveals differential impact during female reproductive mucosal CD8 resident memory T cell differentiation. Mohammad H Hasan

22 de February de 2026 by inmunoadmin

Mucosal Immunol. 2026 Feb 19:S1933-0219(26)00022-X. doi: 10.1016/j.mucimm.2026.02.005. Online ahead of print. ABSTRACT Resident memory CD8 T cell (TRM) development progresses through distinct stages beginning with activation of naive T cells into effectors in lymphoid organs, trafficking of effectors to target tissue via blood, and final TRM differentiation at the tissue of residence under the influence … Read more

Mucosal IL-36 is a defining feature of severe paediatric bronchiolitis. Megan V C Barnes

12 de February de 2026 by inmunoadmin

Mucosal Immunol. 2026 Feb 9:S1933-0219(26)00012-7. doi: 10.1016/j.mucimm.2026.01.012. Online ahead of print. ABSTRACT RATIONALE: Bronchiolitis is the commonest cause of hospital admission in children under the age of 1 year, most cases being due to respiratory syncytial virus (RSV) infection. The mechanisms causing infantile bronchiolitis are incompletely understood but include a deficient mucosal interferon response, neutrophilic … Read more

Indoor rewilding of laboratory mice recalibrates pulmonary mucosal immunity and mechanics. Mohamed Lala Bouali

9 de February de 2026 by inmunoadmin

Mucosal Immunol. 2026 Feb 6:S1933-0219(26)00016-4. doi: 10.1016/j.mucimm.2026.02.003. Online ahead of print. ABSTRACT Laboratory mice raised under specific-pathogen-free (SPF) conditions experience restricted microbial and antigenic exposure, which favours an immature immune system and limits their translational value for respiratory research. While microbial enrichment in “dirty” mouse models restores immune maturation, its impact on integrated respiratory function … Read more

Fibroblasts sense commensal-derived metabolites and regulate group 2 innate lymphoid cells-dependent defense in the stomach. Naoko Satoh-Takayama

8 de February de 2026 by inmunoadmin

Mucosal Immunol. 2026 Feb 5:S1933-0219(26)00007-3. doi: 10.1016/j.mucimm.2026.01.007. Online ahead of print. ABSTRACT Group 2 innate lymphoid cells (ILC2s) contribute to mucosal homeostasis and initiate immune responses against gastrointestinal pathogens, including those that target the stomach. However, the role of commensal bacteria in promoting stomach immunity is unknown. Here, we report that YL27, a commensal bacterium … Read more

EPICERTIN, an engineered variant of cholera toxin B subunit, promotes survival and a pro-remodeling macrophage phenotype for mucosal healing in colitis. Noel Verjan Garcia

7 de February de 2026 by inmunoadmin

Mucosal Immunol. 2026 Feb 4:S1933-0219(26)00013-9. doi: 10.1016/j.mucimm.2026.01.013. Online ahead of print. ABSTRACT EPICERTIN, a modified cholera toxin B subunit (CTB), facilitates mucosal healing in preclinical colitis models, but its anti-inflammatory mechanisms remain unclear. Here, we investigated EPICERTIN’s effects on macrophages. In a dextran sulfate sodium-induced colitis mouse model, oral administration of EPICERTIN reduced neutrophil infiltration … Read more

Expression of CD103 facilitates localization and activation of CD4+ T cells within Mycobacterium tuberculosis lung-lesions. Thomas Lindenstrøm

6 de February de 2026 by inmunoadmin

Mucosal Immunol. 2026 Feb 3:S1933-0219(26)00014-0. doi: 10.1016/j.mucimm.2026.02.001. Online ahead of print. ABSTRACT The spatial localization of CD4+ T cells within the Mycobacterium tuberculosis (Mtb)-infected lung is critical for optimal immunity. Here, we investigate the role of two E-cadherin binding receptors, CD103 and KLRG1. We demonstrate that KLRG1 restricts CD4+ T cells to the lung vasculature … Read more