Mucosal Immunology

Mucosal Immunol. 2025 Nov 28:S1933-0219(25)00129-1. doi: 10.1016/j.mucimm.2025.11.012. Online ahead of print. ABSTRACT Natural Killer (NK) cells are cytotoxic lymphocytes and key mediators of innate immunity, essential for combating viral infections and cancer. Notably, they exhibit immunological memory, generating a stronger response upon re-exposure to the same stimulus. While NK cell memory holds promise for infection … Read more

Mucosal Immunol. 2025 Nov 27:S1933-0219(25)00130-8. doi: 10.1016/j.mucimm.2025.11.013. Online ahead of print. ABSTRACT Inflammatory Bowel Disease (IBD) is a chronic inflammatory condition affecting the gastrointestinal tract. It is characterised by epithelial and immunological dysfunctions, including alterations in populations of Innate Lymphoid Cells (ILCs), including tissue-resident RORγt-expressing Group 3 ILCs (ILC3s). ILC3s contribute to the maintenance of … Read more

Mucosal Immunol. 2025 Nov 22:S1933-0219(25)00128-X. doi: 10.1016/j.mucimm.2025.11.011. Online ahead of print. ABSTRACT Germinal centres (GCs) in mucosal tissues such as the nasal associated lymphoid tissue (NALT) generate high-affinity antibodies critical for protective, and in some cases, sterilising immunity. Therefore, initiation of GCs at the respiratory mucosa is of tremendous clinical significance in the development of … Read more

Mucosal Immunol. 2025 Nov 20:S1933-0219(25)00127-8. doi: 10.1016/j.mucimm.2025.11.010. Online ahead of print. ABSTRACT We have previously demonstrated that the circadian clock regulates the host response to influenza A virus (IAV) infection. While IL-10 is well-known for its immunoregulatory function, its role in IAV remains unclear, with studies reporting both protective and detrimental effects. Given the diurnal … Read more

Mucosal Immunol. 2025 Nov 20:S1933-0219(25)00126-6. doi: 10.1016/j.mucimm.2025.11.009. Online ahead of print. ABSTRACT Seminal fluid elicits an immune response in the uterine mucosa after mating that impacts embryo implantation and pregnancy, but the underlying molecular and cellular events are unclear. In this study, we report RNA sequencing to analyse the uterine response to seminal fluid after … Read more

Mucosal Immunol. 2025 Nov 19:S1933-0219(25)00121-7. doi: 10.1016/j.mucimm.2025.11.004. Online ahead of print. ABSTRACT Airborne fungi are potent inducers of respiratory disease and cause the debilitating conditions severe asthma with fungal sensitisation (SAFS) and allergic bronchopulmonary aspergillosis (ABPA). However, the immune cell types and the inflammatory airway environment that defines SAFS and ABPA patients is not extensively … Read more

Mucosal Immunol. 2025 Nov 17:S1933-0219(25)00125-4. doi: 10.1016/j.mucimm.2025.11.008. Online ahead of print. ABSTRACT The mucosal immune system plays a fundamental role in maintaining microbial balance. Microbial imbalance in the female genital tract increases the risk for adverse health outcomes in women and may increase susceptibility to local infections. Myeloid-derived suppressor cells (MDSCs) remain understudied in the … Read more

Mucosal Immunol. 2025 Nov 15:S1933-0219(25)00124-2. doi: 10.1016/j.mucimm.2025.11.007. Online ahead of print. ABSTRACT Macrophages are crucial for the maintenance of intestinal homeostasis, are considered key proinflammatory effector cells during intestinal inflammation and are implicated in tissue repair following injury or inflammation. Whether these roles are attributed to distinct subsets of macrophages or if macrophages retain a … Read more

Mucosal Immunol. 2025 Nov 13:S1933-0219(25)00123-0. doi: 10.1016/j.mucimm.2025.11.006. Online ahead of print. ABSTRACT The major fungal allergen Alt a 1 from Alternaria alternata is linked to allergic asthma. We assessed its biological role in nutritional immunity to iron and its allergenic potential using in silico, in vitro, and in vivo approaches. Alternaria was cultured with or … Read more

Mucosal Immunol. 2025 Nov 14:S1933-0219(25)00119-9. doi: 10.1016/j.mucimm.2025.11.002. Online ahead of print. NO ABSTRACT PMID:41241599 | DOI:10.1016/j.mucimm.2025.11.002