Mucosal Immunology

Single cell atlas of lung-resident innate lymphoid cells shows impact of age and dysbiosis on epigenetic and transcriptomic programming. Madeline Bonfield

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Mucosal Immunol. 2026 Jan 17:S1933-0219(26)00004-8. doi: 10.1016/j.mucimm.2026.01.004. Online ahead of print. ABSTRACT The mechanisms underlying innate lymphoid cell (ILC) development and function in the neonatal lung remain incompletely defined. ILCs are critical mediators of early-life innate immune responses in the lung. Dysregulation of ILC homeostasis has both immediate and long-lasting effects on lung health. We … Read more

IL-11 acts as an alarmin-like pro-inflammatory mediator regulating mucosal responses during helminth infection. Pedro H Gazzinelli-Guimaraes

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Mucosal Immunol. 2026 Jan 16:S1933-0219(26)00005-X. doi: 10.1016/j.mucimm.2026.01.005. Online ahead of print. ABSTRACT Lung-trafficking helminth larvae drive an early pulmonary neutrophilic inflammation prior to the establishment of the hallmark Type 2 immune response. While IL-11 is known to play crucial roles in chronic inflammatory responses, its role in the mucosal immunity to helminth parasites has not … Read more

Integrated human and mouse single-cell profiling reveals immune-stromal niche driving silicosis. Christina Begka

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Mucosal Immunol. 2026 Jan 9:S1933-0219(26)00003-6. doi: 10.1016/j.mucimm.2026.01.003. Online ahead of print. ABSTRACT Silicosis is an inflammation-driven pulmonary fibrosis caused by occupational inhalation of silica particles. Macrophages are crucial in silicosis pathology, yet their interaction with stromal cells in orchestrating fibrosis progression remains poorly understood. Single-cell RNA sequencing (scRNAseq) of whole-lung lavages from silicosis patients identified … Read more

Distinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthma. Rod A Rahimi

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Mucosal Immunol. 2026 Jan 8:S1933-0219(26)00001-2. doi: 10.1016/j.mucimm.2026.01.001. Online ahead of print. ABSTRACT T cells play a central role in host protection against respiratory pathogens, but a maladaptive T cell response can lead to pulmonary diseases. Previous studies have examined T cells from the lungs captured via bronchoalveolar lavage (BAL), endobronchial brushings, or biopsies. However, whether … Read more

Trained ILC2 prevent IL-17-associated lung injury during helminth infection through a serotonin-dependent mechanism. Ulrich Membe Femoe

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Mucosal Immunol. 2026 Jan 7:S1933-0219(26)00002-4. doi: 10.1016/j.mucimm.2026.01.002. Online ahead of print. ABSTRACT Type 2 cytokinerelease promotes wound healing and helminth clearance, but it remains unclearwhethergroup 2 innate lymphocytes (ILC2s) and T-helper2 cells (TH2) cells have functionally distinctroles during anamnestic immunity. This study demonstrates that ILC2 can prevent re-infection andlimit tissue injury caused by the helminthNippostrongylus … Read more

Single-cell transcriptome analysis reveals the association between ketone body synthesis and morphogenic profile of intestinal epithelia in neonatal mice. Kyoko Matsuki

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Mucosal Immunol. 2025 Dec 30:S1933-0219(25)00141-2. doi: 10.1016/j.mucimm.2025.12.005. Online ahead of print. ABSTRACT The intestinal epithelium undergoes robust maturation postnatally, yet its early-life characteristics remain poorly understood. Using single-cell RNA sequencing, we analyzed intestinal epithelial cells from neonatal (10-day-old) and juvenile (21-day-old) mice reared under both specific pathogen-free and germ-free conditions. Among the various cell types … Read more

Regulatory T cells protect against aberrant remodeling in a mouse model of pulmonary fibrosis. Aditi Murthy

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Mucosal Immunol. 2025 Dec 27:S1933-0219(25)00140-0. doi: 10.1016/j.mucimm.2025.12.004. Online ahead of print. ABSTRACT Regulatory T (Treg) cells are well recognized for their role in immune regulation; however, their role in tissue regeneration is not fully understood. This study demonstrates such a role of Tregs in a published preclinical murine model of spontaneous pulmonary fibrosis (PF) expressing … Read more

Wheat fiber-induced peripheral regulatory T-cells suppress development of colitis. Seong-Eun G Kim

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Mucosal Immunol. 2025 Dec 22:S1933-0219(25)00139-4. doi: 10.1016/j.mucimm.2025.12.003. Online ahead of print. ABSTRACT Reduced dietary fiber intake is associated with, and may have contributed to, the post-mid-20th century increase in immune-mediated chronic inflammatory diseases, including inflammatory bowel disease (IBD). Reduced fiber intake has resulted, in part, from increased consumption of highly refined foods including those made … Read more

The gut-liver axis modulates intestinal immune homeostasis. Yang Gu

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Mucosal Immunol. 2025 Dec 21:S1933-0219(25)00137-0. doi: 10.1016/j.mucimm.2025.12.001. Online ahead of print. ABSTRACT The intestine and liver are physically interconnected through the biliary system, portal circulation, lymphatic network, and neural pathways, collectively forming the gut-liver axis. The gut-liver axis and the immune system are engaged in a complex regulatory relationship. Over the past few decades, significant … Read more

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