Mucosal Immunology

Mucosal Immunol. 2025 Jul 26:S1933-0219(25)00077-7. doi: 10.1016/j.mucimm.2025.07.006. Online ahead of print. ABSTRACT The nasal, oropharyngeal, and bronchial mucosa are primary contact points for airborne pathogens like Mycobacterium tuberculosis (Mtb), SARS-CoV-2, and influenza virus. While mucosal surfaces can function as both entry points and barriers to infection, mucosa-associated lymphoid tissues (MALT) facilitate early immune responses to … Read more

Mucosal Immunol. 2025 Jul 22:S1933-0219(25)00078-9. doi: 10.1016/j.mucimm.2025.07.007. Online ahead of print. ABSTRACT The nasal cavity is the entry site for respiratory viruses. Understanding how the nasal cavity sustains memory CD8+ T cell is essential for improving respiratory virus management and vaccine development. Here, we sampled CD8+ T cells from the upper nasal turbinate and peripheral … Read more

Mucosal Immunol. 2025 Jul 20:S1933-0219(25)00073-X. doi: 10.1016/j.mucimm.2025.07.002. Online ahead of print. ABSTRACT Advancements in vaccination and sanitation have significantly reduced the prevalence and burden of infectious diseases; however, these benefits have coincided with a marked rise in autoimmune and allergic disorders. Recent studies have investigated these linked trends through the lens of host-microbiome alterations, proposing … Read more

Mucosal Immunol. 2025 Jul 19:S1933-0219(25)00075-3. doi: 10.1016/j.mucimm.2025.07.004. Online ahead of print. ABSTRACT Apolipoprotein E (APOE) expressed by macrophages modulates allergic inflammation and remodeling of the lower airway. However, its expression and functions in chronic rhinosinusitis with nasal polyps (CRSwNP) remain unclear. We sought to investigate the involvement of macrophage derived APOE in the pathogenesis of … Read more

Mucosal Immunol. 2025 Jul 17:S1933-0219(25)00076-5. doi: 10.1016/j.mucimm.2025.07.005. Online ahead of print. ABSTRACT Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mice harboring a microbiota-specific hyperproliferative γδ IEL (γδHYP) phenotype also upregulate the expression of the ectonucleotidase CD39, a marker of regulatory γδ T … Read more

Mucosal Immunol. 2025 Jul 16:S1933-0219(25)00074-1. doi: 10.1016/j.mucimm.2025.07.003. Online ahead of print. ABSTRACT Alveolar macrophages (AMs) and dendritic cells (DCs) are the two major types of primary innate immune cells in allergic asthma and their functions were elaborately regulated during the progression of asthma. Tripartite motif-containing protein 33 (TRIM33) is a multifunctional protein that regulates differentiation … Read more

Mucosal Immunol. 2025 Jul 10:S1933-0219(25)00072-8. doi: 10.1016/j.mucimm.2025.07.001. Online ahead of print. ABSTRACT Vulvovaginal candidiasis (VVC) is a mucosal infection predominantly caused by Candida albicans, affecting over three-quarters of immunocompetent women worldwide. While the female genital tract mucosa is the primary defense against the fungus, the specific immune mechanisms involved in this host-pathogen interaction remain largely … Read more

Mucosal Immunol. 2025 Jul 2:S1933-0219(25)00070-4. doi: 10.1016/j.mucimm.2025.06.010. Online ahead of print. ABSTRACT Patients with autoimmune diseases are more susceptible to foodborne infections, which can be exacerbated by immunosuppressive therapy. Tofacitinib, a JAK/STAT pathway inhibitor, was recently approved for the treatment of ulcerative colitis, yet its effects on the pathogenesis of intestinal infections remain unclear. Here, … Read more

Mucosal Immunol. 2025 Jul 1:S1933-0219(25)00071-6. doi: 10.1016/j.mucimm.2025.06.011. Online ahead of print. ABSTRACT Macrophages play essential roles in immune defense and tissue homeostasis, but the mechanisms underlying their colonization in the gut mucosa remain incompletely understood. Here, we identify CSF1, primarily derived from fibroblasts, as the dominant factor maintaining mucosal macrophage colonization, whereas IL-34 deficiency alone … Read more

Mucosal Immunol. 2025 Jun 27:S1933-0219(25)00068-6. doi: 10.1016/j.mucimm.2025.06.008. Online ahead of print. ABSTRACT Poorly controlled diabetes significantly transforms periodontal disease from manageable to advanced, affecting millions worldwide, yet the mechanisms driving this destructive synergy remain unclear. To investigate these pathological interactions, we generated single-cell RNA sequencing profiles of diabetic periodontal tissue, revealing γδ T-cells as previously … Read more