Mucosal Immunology

Natural Killer T follicular helper cell function permits affinity maturation in nasal associated lymphoid tissue. Isabelle Montgomerie

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Mucosal Immunol. 2025 Nov 22:S1933-0219(25)00128-X. doi: 10.1016/j.mucimm.2025.11.011. Online ahead of print. ABSTRACT Germinal centres (GCs) in mucosal tissues such as the nasal associated lymphoid tissue (NALT) generate high-affinity antibodies critical for protective, and in some cases, sterilising immunity. Therefore, initiation of GCs at the respiratory mucosa is of tremendous clinical significance in the development of … Read more

Role of IL-10 signaling in the circadian control of host response to influenza infection. Kaitlyn M Forrest

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Mucosal Immunol. 2025 Nov 20:S1933-0219(25)00127-8. doi: 10.1016/j.mucimm.2025.11.010. Online ahead of print. ABSTRACT We have previously demonstrated that the circadian clock regulates the host response to influenza A virus (IAV) infection. While IL-10 is well-known for its immunoregulatory function, its role in IAV remains unclear, with studies reporting both protective and detrimental effects. Given the diurnal … Read more

Seminal fluid expands the uterine gamma/delta T cell pool during early pregnancy in mice. Kerrie L Foyle

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Mucosal Immunol. 2025 Nov 20:S1933-0219(25)00126-6. doi: 10.1016/j.mucimm.2025.11.009. Online ahead of print. ABSTRACT Seminal fluid elicits an immune response in the uterine mucosa after mating that impacts embryo implantation and pregnancy, but the underlying molecular and cellular events are unclear. In this study, we report RNA sequencing to analyse the uterine response to seminal fluid after … Read more

Activation status of airway immune cells is a defining feature of severe asthma, regardless of fungal sensitisation. Emily L Plumpton

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Mucosal Immunol. 2025 Nov 19:S1933-0219(25)00121-7. doi: 10.1016/j.mucimm.2025.11.004. Online ahead of print. ABSTRACT Airborne fungi are potent inducers of respiratory disease and cause the debilitating conditions severe asthma with fungal sensitisation (SAFS) and allergic bronchopulmonary aspergillosis (ABPA). However, the immune cell types and the inflammatory airway environment that defines SAFS and ABPA patients is not extensively … Read more

Cervical mucosal inflammation expands functional polymorphonuclear myeloid-derived suppressor cells. Daan K J Pieren

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Mucosal Immunol. 2025 Nov 17:S1933-0219(25)00125-4. doi: 10.1016/j.mucimm.2025.11.008. Online ahead of print. ABSTRACT The mucosal immune system plays a fundamental role in maintaining microbial balance. Microbial imbalance in the female genital tract increases the risk for adverse health outcomes in women and may increase susceptibility to local infections. Myeloid-derived suppressor cells (MDSCs) remain understudied in the … Read more

Tissue resident colonic macrophages persist through acute inflammation and adapt to aid tissue repair. Lizi M Hegarty

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Mucosal Immunol. 2025 Nov 15:S1933-0219(25)00124-2. doi: 10.1016/j.mucimm.2025.11.007. Online ahead of print. ABSTRACT Macrophages are crucial for the maintenance of intestinal homeostasis, are considered key proinflammatory effector cells during intestinal inflammation and are implicated in tissue repair following injury or inflammation. Whether these roles are attributed to distinct subsets of macrophages or if macrophages retain a … Read more

Iron-Dependent allergenicity of Alt a 1: A link between fungal nutritional immunity and allergic sensitization. Aila Fakhimahmadi

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Mucosal Immunol. 2025 Nov 13:S1933-0219(25)00123-0. doi: 10.1016/j.mucimm.2025.11.006. Online ahead of print. ABSTRACT The major fungal allergen Alt a 1 from Alternaria alternata is linked to allergic asthma. We assessed its biological role in nutritional immunity to iron and its allergenic potential using in silico, in vitro, and in vivo approaches. Alternaria was cultured with or … Read more

Lung basement membranes are compositionally and structurally altered following resolution of influenza infection. Oliver Brand

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Mucosal Immunol. 2025 Nov 11:S1933-0219(25)00122-9. doi: 10.1016/j.mucimm.2025.11.005. Online ahead of print. ABSTRACT Identification of pathways preventing timely recovery from acute respiratory viral infection is under-studied but essential for long-term health. Using unbiased proteomics, we reveal an unexpected, reduction in lung basement membrane proteins 21 days after influenza infection when mice had symptomatically recovered. Basement membrane … Read more

Pantothenic acid alleviates endometrial injury induced by vagotomy in mice. Chongshan Yuan

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Mucosal Immunol. 2025 Nov 10:S1933-0219(25)00120-5. doi: 10.1016/j.mucimm.2025.11.003. Online ahead of print. ABSTRACT Endometrial injury triggers inflammation responses, and persistent inflammation is a recognized cause of infertility. Emerging evidence underscores the critical role of the vagus nerve in modulating immunity. Although vagotomy is known to induce systemic inflammation, the specific mechanism by which the vagus nerve … Read more

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