Mucosal Immunology

Activation status of airway immune cells is a defining feature of severe asthma, regardless of fungal sensitisation. Emily L Plumpton

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Mucosal Immunol. 2025 Nov 19:S1933-0219(25)00121-7. doi: 10.1016/j.mucimm.2025.11.004. Online ahead of print. ABSTRACT Airborne fungi are potent inducers of respiratory disease and cause the debilitating conditions severe asthma with fungal sensitisation (SAFS) and allergic bronchopulmonary aspergillosis (ABPA). However, the immune cell types and the inflammatory airway environment that defines SAFS and ABPA patients is not extensively … Read more

Cervical mucosal inflammation expands functional polymorphonuclear myeloid-derived suppressor cells. Daan K J Pieren

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Mucosal Immunol. 2025 Nov 17:S1933-0219(25)00125-4. doi: 10.1016/j.mucimm.2025.11.008. Online ahead of print. ABSTRACT The mucosal immune system plays a fundamental role in maintaining microbial balance. Microbial imbalance in the female genital tract increases the risk for adverse health outcomes in women and may increase susceptibility to local infections. Myeloid-derived suppressor cells (MDSCs) remain understudied in the … Read more

Tissue resident colonic macrophages persist through acute inflammation and adapt to aid tissue repair. Lizi M Hegarty

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Mucosal Immunol. 2025 Nov 15:S1933-0219(25)00124-2. doi: 10.1016/j.mucimm.2025.11.007. Online ahead of print. ABSTRACT Macrophages are crucial for the maintenance of intestinal homeostasis, are considered key proinflammatory effector cells during intestinal inflammation and are implicated in tissue repair following injury or inflammation. Whether these roles are attributed to distinct subsets of macrophages or if macrophages retain a … Read more

Iron-Dependent allergenicity of Alt a 1: A link between fungal nutritional immunity and allergic sensitization. Aila Fakhimahmadi

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Mucosal Immunol. 2025 Nov 13:S1933-0219(25)00123-0. doi: 10.1016/j.mucimm.2025.11.006. Online ahead of print. ABSTRACT The major fungal allergen Alt a 1 from Alternaria alternata is linked to allergic asthma. We assessed its biological role in nutritional immunity to iron and its allergenic potential using in silico, in vitro, and in vivo approaches. Alternaria was cultured with or … Read more

Lung basement membranes are compositionally and structurally altered following resolution of influenza infection. Oliver Brand

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Mucosal Immunol. 2025 Nov 11:S1933-0219(25)00122-9. doi: 10.1016/j.mucimm.2025.11.005. Online ahead of print. ABSTRACT Identification of pathways preventing timely recovery from acute respiratory viral infection is under-studied but essential for long-term health. Using unbiased proteomics, we reveal an unexpected, reduction in lung basement membrane proteins 21 days after influenza infection when mice had symptomatically recovered. Basement membrane … Read more

Pantothenic acid alleviates endometrial injury induced by vagotomy in mice. Chongshan Yuan

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Mucosal Immunol. 2025 Nov 10:S1933-0219(25)00120-5. doi: 10.1016/j.mucimm.2025.11.003. Online ahead of print. ABSTRACT Endometrial injury triggers inflammation responses, and persistent inflammation is a recognized cause of infertility. Emerging evidence underscores the critical role of the vagus nerve in modulating immunity. Although vagotomy is known to induce systemic inflammation, the specific mechanism by which the vagus nerve … Read more

Placental intervillous blood harbors NK cells with distinct tissue-resident characteristics. Sara Vikberg

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Mucosal Immunol. 2025 Nov 4:S1933-0219(25)00117-5. doi: 10.1016/j.mucimm.2025.11.001. Online ahead of print. ABSTRACT The placental intervillous space is a unique immunological niche where circulating maternal immune cells come into direct contact with the fetal syncytiotrophoblast. While adaptations in immune cell composition are known to occur in the maternal decidua throughout pregnancy, it remains unclear whether similar … Read more

Protection against reinfection with Mycobacterium tuberculosis extends across heterologous Mtb lineages. Andrew W Simonson

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Mucosal Immunol. 2025 Nov 2:S1933-0219(25)00115-1. doi: 10.1016/j.mucimm.2025.10.010. Online ahead of print. ABSTRACT Immunological memory elicited either through previous or ongoing M. tuberculosis (Mtb) infection provides a critical mechanism by which hosts protect against re-infection and disease progression upon Mtb re-exposure. Conversely, the uneven competition between distinct Mtb strains suggest certain bacterial clades have enhanced ability … Read more

IFN-γ- GranzymeB + Natural killer cells are induced by IV BCG vaccination and associated with protection against tuberculosis in rhesus macaques. Mohau S Makatsa

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Mucosal Immunol. 2025 Nov 1:S1933-0219(25)00116-3. doi: 10.1016/j.mucimm.2025.10.011. Online ahead of print. ABSTRACT Intravenous (IV) vaccination with Bacillus Calmette-Guerin (BCG) mediates sterilizing immunity against Mycobacterium tuberculosis (Mtb) in rhesus macaques but the cellular mechanisms underlying protection are undefined. We used mass cytometry (CyTOF) to broadly profile pulmonary immunity induced by IV BCG and observed an expansion … Read more

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