Mucosal Immunol. 2025 Feb 18:S1933-0219(25)00019-4. doi: 10.1016/j.mucimm.2025.02.001. Online ahead of print. ABSTRACT Influenza virus infection is a leading cause of morbidity and mortality worldwide, posing a significant public health problem. The pro-inflammatory cytokine interleukin-6 (IL-6) has been shown to promote defense against respiratory viral infection, while excessive IL-6 responses have been associated with severe pneumonia. … Read more

Mucosal Immunol. 2025 Feb 5:S1933-0219(25)00010-8. doi: 10.1016/j.mucimm.2025.01.010. Online ahead of print. ABSTRACT The ocular surface microbiota plays a critical role in maintaining corneal homeostasis, but its disruption and subsequent effects on corneal functions remain poorly understood. This study investigates how antibiotic-induced microbial depletion affects the corneal circadian transcriptome in C57BL/6J mice. Dysbiosis was induced using … Read more

Mucosal Immunol. 2025 Feb 5:S1933-0219(25)00013-3. doi: 10.1016/j.mucimm.2025.01.013. Online ahead of print. ABSTRACT Mitochondria are key regulators of inflammatory responses and mitochondrial dysfunction is closely linked to various inflammatory diseases. Increasing genetic and experimental evidence suggests that mitochondria play a critical role in inflammatory bowel disease (IBD). In the complex environment of the intestinal tract, intestinal … Read more

Mucosal Immunol. 2025 Feb 1:S1933-0219(25)00012-1. doi: 10.1016/j.mucimm.2025.01.012. Online ahead of print. ABSTRACT Innate lymphoid cells (ILC) have emerged as critical immune effectors with key roles in orchestrating the wider immune response. While ILC are relatively rare cells they are found enriched within discrete microenvironments, predominantly within barrier tissues. An emerging body of evidence implicates complex … Read more

Mucosal Immunol. 2025 Feb 1:S1933-0219(25)00009-1. doi: 10.1016/j.mucimm.2025.01.009. Online ahead of print. ABSTRACT The ocular mucosal surface regularly encounters external materials in the air and tear fluids. Microfold (M) cells, specialized epithelial cells for antigen uptake, are present in tear duct-associated lymphoid tissue (TALT) within the nasolacrimal sac; however, their immunological significance is unclear. We generated … Read more

Mucosal Immunol. 2025 Jan 31:S1933-0219(25)00011-X. doi: 10.1016/j.mucimm.2025.01.011. Online ahead of print. ABSTRACT Gut inflammatory diseases cause microbial dysbiosis. Human immunodeficiency virus-1 (HIV) infection disrupts intestinal integrity, subverts repair/renewal pathways, impairs mucosal immunity and propels microbial dysbiosis. However, microbial metabolic mechanisms driving repair mechanisms in virally inflamed gut are not well understood. We investigated the capability … Read more

Mucosal Immunol. 2025 Jan 28:S1933-0219(25)00008-X. doi: 10.1016/j.mucimm.2025.01.008. Online ahead of print. ABSTRACT Host response aimed at eliminating the infecting pathogen, as well as the pathogen itself, can cause tissue injury. Tissue injury leads to the release of a myriad of cellular components including mitochondrial DNA, which the host senses through pattern recognition receptors. How the … Read more

Mucosal Immunol. 2025 Jan 25:S1933-0219(25)00007-8. doi: 10.1016/j.mucimm.2025.01.007. Online ahead of print. ABSTRACT Maternal obesity is a condition with increasing prevalence worldwide, that correlates with negative infant outcomes. Here we performed an observational cross-sectional study, where peripheral blood and colostrum samples from 37 mothers with BMI between 18.5-25 or > 30 kg/m2 (21 and 16 mothers, … Read more

Mucosal Immunol. 2025 Jan 23:S1933-0219(25)00006-6. doi: 10.1016/j.mucimm.2025.01.006. Online ahead of print. ABSTRACT Our immune system and gut microbiota are intricately coupled from birth, both going through maturation during early life and senescence during aging almost in a synchronized fashion. The symbiotic relationship between the human host and microbiota is critically dependent on a healthy immune … Read more

Mucosal Immunol. 2025 Jan 21:S1933-0219(25)00001-7. doi: 10.1016/j.mucimm.2025.01.001. Online ahead of print. NO ABSTRACT PMID:39843282 | DOI:10.1016/j.mucimm.2025.01.001