Mucosal Immunology

Mucosal Immunol. 2024 Aug 21:S1933-0219(24)00089-8. doi: 10.1016/j.mucimm.2024.08.008. Online ahead of print. ABSTRACT Acute respiratory distress syndrome (ARDS) is a life-threatening condition characterized by severe inflammation and pulmonary dysfunction. Despite advancements in critical care, effective pharmacological interventions for ARDS remain elusive. While Janus kinase 2 (JAK2) inhibitors have emerged as an innovative treatment for numerous autoinflammatory … Read more

Mucosal Immunol. 2024 Aug 20:S1933-0219(24)00088-6. doi: 10.1016/j.mucimm.2024.08.007. Online ahead of print. ABSTRACT PLX5622 is a small molecular inhibitor of the CSF1 receptor (CSF1R) and is widely used to deplete macrophages within the central nervous system (CNS). We investigated the impact of PLX5622 treatment in wild-type C57BL/6 mice and discovered that one-week treatment with PLX5622 was … Read more

Mucosal Immunol. 2024 Sep 25:S1933-0219(24)00097-7. doi: 10.1016/j.mucimm.2024.09.004. Online ahead of print. ABSTRACT Inflammatory bowel disease (IBD) chronicity results from memory T helper cell (Tmem) reactivation. Identifying patient-specific immunotypes is crucial for tailored treatment. We conducted a comprehensive study integrating circulating immune proteins and circulating Tmem, with intestinal tissue histology and mRNA analysis, in therapy-naïve pediatric … Read more

Mucosal Immunol. 2024 Sep 16:S1933-0219(24)00096-5. doi: 10.1016/j.mucimm.2024.09.003. Online ahead of print. ABSTRACT The host-microbiome axis has been implicated in promoting anti-inflammatory immune responses. Yet, the underlying molecular mechanisms of commensal-mediated IL-10 production by regulatory B cells (Bregs) are not fully elucidated. Here, we demonstrate that bacterial CpG motifs trigger the signaling downstream of TLR9 promoting … Read more

Mucosal Immunol. 2024 Sep 25:S1933-0219(24)00098-9. doi: 10.1016/j.mucimm.2024.09.005. Online ahead of print. ABSTRACT Inflammatory bowel disease (IBD) is characterized by very severe intestinal inflammation associated with extra-intestinal manifestations. One of the most critical ones is bone destruction, which remains a major cause of morbidity and a risk factor for osteopenia and osteoporosis in IBD patients. In … Read more

Mucosal Immunology, Published online: 21 November 2022; doi:10.1038/s41385-022-00578-9Mucosal immunization with a delta-inulin adjuvanted recombinant spike vaccine elicits lung-resident immune memory and protects mice against SARS-CoV-2

Mucosal Immunology, Published online: 15 November 2022; doi:10.1038/s41385-022-00579-8Intestinal epithelium in early life

Mucosal Immunology, Published online: 13 November 2022; doi:10.1038/s41385-022-00577-wEpithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with inflammatory bo…

Mucosal Immunology, Published online: 09 November 2022; doi:10.1038/s41385-022-00576-xSeverity of neonatal influenza infection is driven by type I interferon and oxidative stress

Mucosal Immunology, Published online: 03 November 2022; doi:10.1038/s41385-022-00574-zResistance is futile? Mucosal immune mechanisms in the context of microbial ecology and evolution