Mucosal Immunology

Gut-homing and intestinal TIGITnegCD38+ memory T cells acquire an IL-12-induced, ex-Th17 pathogenic phenotype in a subgroup of Crohn’s disease patients with a severe disease course. Maud Heredia

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Mucosal Immunol. 2024 Nov 23:S1933-0219(24)00116-8. doi: 10.1016/j.mucimm.2024.11.008. Online ahead of print. ABSTRACT CD4+ memory T cell (TM) reactivation drives chronicity in inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis. Defects driving loss of TM regulation likely differ between patients but remain undefined. In health, approximately 40 % of circulating gut-homing CD38+TM, express … Read more

IgA facilitates the persistence of the mucosal pathogen Helicobacter pylori. Mariela Artola-Borán

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Mucosal Immunol. 2024 Nov 22:S1933-0219(24)00113-2. doi: 10.1016/j.mucimm.2024.11.006. Online ahead of print. ABSTRACT IgA antibodies have an important role in clearing mucosal pathogens. In this study, we have examined the contribution of IgA to the immune control of the gastrointestinal bacterial pathogens Helicobacter pylori and Citrobacter rodentium. Both bacteria trigger a strong local IgA response that … Read more

Herpes stromal keratitis erodes the establishment of tissue-resident memory T cell pool in HSV-1 infected corneas. Mizumi Setia

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Mucosal Immunol. 2024 Nov 22:S1933-0219(24)00111-9. doi: 10.1016/j.mucimm.2024.11.003. Online ahead of print. ABSTRACT The recurrent herpes simplex virus-1 (HSV-1) infection of the cornea can cause the development of herpes stromal keratitis (HSK). This chronic immunoinflammatory condition is a major cause of infection-induced vision loss. The previous episodes of HSK increase the risk of future recurrences in … Read more

The C-type lectin receptor MINCLE interferes with eosinophil function and protective intestinal immunity in Strongyloides ratti-infected mice. Lara Linnemann

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Mucosal Immunol. 2024 Nov 22:S1933-0219(24)00114-4. doi: 10.1016/j.mucimm.2024.11.005. Online ahead of print. ABSTRACT Strongyloides ratti is a helminth parasite that displays tissue-migrating and intestinal life stages. Myeloid C-type lectin receptors (CLRs) are pattern recognition receptors that recognize pathogen-derived ligands and initiate immune responses. To date, the role of CLRs in S. ratti infection has not been … Read more

Card9 and MyD88 differentially regulate Th17 immunity to the commensal yeast Malassezia in the murine skin. Meret Tuor

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Mucosal Immunol. 2024 Nov 21:S1933-0219(24)00112-0. doi: 10.1016/j.mucimm.2024.11.004. Online ahead of print. ABSTRACT The fungal community of the skin microbiome is dominated by a single genus, Malassezia. Besides its symbiotic lifestyle at the host interface, this commensal yeast has also been associated with diverse inflammatory skin diseases in humans and pet animals. Stable colonization is maintained … Read more

Activation of α2B/2C adrenergic receptor ameliorates ocular surface inflammation through enhancing regulatory T cell function. Nai-Wen Fan

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Mucosal Immunol. 2024 Nov 8:S1933-0219(24)00110-7. doi: 10.1016/j.mucimm.2024.11.002. Online ahead of print. ABSTRACT There is an unmet need for effectively treating dry eye disease (DED), a T cell-mediated chronic, inflammatory ocular surface disorder. Given the potential of nonneuronal adrenergic system in modulating T cell response, we herein investigated the therapeutic efficacy and the underlying mechanisms of … Read more

Pro-inflammatory NK-like T cells are expanded in the blood and inflamed intestine in Crohńs disease. Cristina M Chiarolla

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Mucosal Immunol. 2024 Nov 7:S1933-0219(24)00109-0. doi: 10.1016/j.mucimm.2024.11.001. Online ahead of print. ABSTRACT Altered intestinal immune homeostasis leads to chronic inflammation in Crohn’s disease (CD). To address disease- and tissue-specific alterations, we performed a T cell-centric mass cytometry analysis of peripheral and intestinal lymphocytes from patients with CD and healthy donors’ PBMCs. Chronic intestinal inflammation enforced … Read more

Disrupting endogenous retroelements with a reverse transcriptase inhibitor alleviates DSS-induced colitis in mice. Yifan Niu

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Mucosal Immunol. 2023 Oct 27:S1933-0219(23)00082-X. doi: 10.1016/j.mucimm.2023.10.004. Online ahead of print. ABSTRACT Endogenous retroelements play vital roles in sustaining immune homeostasis. Activation of endogenous retroelements can trigger cGAS/STING pathway and downstream pro-inflammatory cytokine production. M1 macrophages, which can be induced by pro-inflammatory cytokines, are involved in the development of colitis. Here we aimed to determine … Read more

Airway macrophage glycolysis controls lung homeostasis and responses to aeroallergen. Gesa J Albers

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Mucosal Immunol. 2024 Oct 17:S1933-0219(24)00105-3. doi: 10.1016/j.mucimm.2024.10.002. Online ahead of print. ABSTRACT The lungs represent a dynamic microenvironment where airway macrophages (AMs) are the major lung-resident macrophages. AMs dictate the balance between tissue homeostasis and immune activation and thus have contradictory functions by maintaining tolerance and tissue homeostasis, as well as initiating strong inflammatory responses. … Read more

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