Mucosal Immunology

Mucosal Immunol. 2025 Oct 24:S1933-0219(25)00113-8. doi: 10.1016/j.mucimm.2025.10.008. Online ahead of print. ABSTRACT Radiotherapy (RT) is essential in treating abdominal and pelvic cancers but often damages the healthy tissues, particularly the intestines, leading to radiation-induced toxicities with limited treatment options. While the immune system is known to help regulate tissue damage, immune mechanisms involved in RT-induced … Read more

Mucosal Immunol. 2025 Oct 26:S1933-0219(25)00114-X. doi: 10.1016/j.mucimm.2025.10.009. Online ahead of print. ABSTRACT The immune balance in mucosal tissues depends on a delicate interplay between inflammatory T helper 17 (Th17) cells and immunosuppressive regulatory T cells (Tregs). But what happens when this balance is disturbed? In this study, we uncovered a critical role for acyl-CoA synthetase … Read more

Mucosal Immunol. 2025 Oct 20:S1933-0219(25)00111-4. doi: 10.1016/j.mucimm.2025.10.006. Online ahead of print. NO ABSTRACT PMID:41120231 | DOI:10.1016/j.mucimm.2025.10.006

Mucosal Immunol. 2025 Oct 19:S1933-0219(25)00112-6. doi: 10.1016/j.mucimm.2025.10.007. Online ahead of print. ABSTRACT Xenobiotics and environmental factors implicated in inflammatory bowel disease (IBD) are metabolized by cytochrome P450 enzymes. Cyp2s1, an orphan member of this family, is highly expressed in the intestine, yet its role remains unclear. Here, we investigated the function of Cyp2s1 in intestinal … Read more

Mucosal Immunol. 2025 Oct 15:S1933-0219(25)00107-2. doi: 10.1016/j.mucimm.2025.10.005. Online ahead of print. ABSTRACT T follicular helper cells (TFH) play a central role in orchestrating antibody mediated immunity. Despite the importance of antibody responses, especially allergen-specific IgE, in allergic airway diseases (AAD) such as asthma, the precise role TFH play in AADs has remained elusive. Using a … Read more

Mucosal Immunol. 2025 Oct 9:S1933-0219(25)00105-9. doi: 10.1016/j.mucimm.2025.10.003. Online ahead of print. ABSTRACT Acute lung injury is a common complication of pneumonia, with disease severity linked to inflammatory cell recruitment and lung barrier dysfunction. In this study, we investigate the role of neutrophil-chemoattractant CXCL5 in lung barrier function and inflammation. We examined CXCL5 in patients with … Read more

Mucosal Immunol. 2025 Oct 9:S1933-0219(25)00104-7. doi: 10.1016/j.mucimm.2025.10.002. Online ahead of print. ABSTRACT The upper airway is comprised of two distinct mucosal surface tissues, the respiratory mucosa (RM) and the olfactory mucosa (OM), both of which are constantly being exposed to airborne pathogens. The olfactory mucosa is responsible for detecting and conveying odorant information into the … Read more

Mucosal Immunol. 2025 Oct 9:S1933-0219(25)00103-5. doi: 10.1016/j.mucimm.2025.10.001. Online ahead of print. ABSTRACT Uropathogenic Escherichia coli is a common pathogen that affects the cauda epididymidis, causing interstitial edema, epithelial damage, leukocyte infiltration, and fibrosis. Despite antibiotic treatment, up to 20 % of patients develop abscesses in the cauda epididymidis, and 40 % experience low sperm counts. … Read more

Mucosal Immunol. 2025 Oct 7:S1933-0219(25)00106-0. doi: 10.1016/j.mucimm.2025.10.004. Online ahead of print. ABSTRACT Group 3 innate lymphoid cells (ILC3) are tissue-resident lymphocytes that contribute to tissue and immune homeostasis. Alterations in ILC3 development or deficiency in their effector functions have beneficial and detrimental outcomes on chronic inflammation, host defense and barrier integrity. Although research has progressed … Read more

Mucosal Immunol. 2025 Sep 30:S1933-0219(25)00096-0. doi: 10.1016/j.mucimm.2025.09.006. Online ahead of print. NO ABSTRACT PMID:41033874 | DOI:10.1016/j.mucimm.2025.09.006