Mucosal Immunology

Epididymitis promotes formation of tertiary lymphoid organs in the cauda epididymidis. Hiba Hasan

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Mucosal Immunol. 2025 Oct 9:S1933-0219(25)00103-5. doi: 10.1016/j.mucimm.2025.10.001. Online ahead of print. ABSTRACT Uropathogenic Escherichia coli is a common pathogen that affects the cauda epididymidis, causing interstitial edema, epithelial damage, leukocyte infiltration, and fibrosis. Despite antibiotic treatment, up to 20 % of patients develop abscesses in the cauda epididymidis, and 40 % experience low sperm counts. … Read more

Group 3 innate lymphoid cell-derived CSF2 tunes homeostasis of tissue macrophages and neutrophils. S L Tai

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Mucosal Immunol. 2025 Oct 7:S1933-0219(25)00106-0. doi: 10.1016/j.mucimm.2025.10.004. Online ahead of print. ABSTRACT Group 3 innate lymphoid cells (ILC3) are tissue-resident lymphocytes that contribute to tissue and immune homeostasis. Alterations in ILC3 development or deficiency in their effector functions have beneficial and detrimental outcomes on chronic inflammation, host defense and barrier integrity. Although research has progressed … Read more

Novel loss-of-function intronic mutation in ELF4 is associated with intestinal autoinflammation. Chunyang Tian

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Mucosal Immunol. 2025 Sep 24:S1933-0219(25)00097-2. doi: 10.1016/j.mucimm.2025.09.007. Online ahead of print. ABSTRACT Monogenic errors of immunity can present with inflammatory bowel disease (IBD)-like enteropathy. We describe an adolescent with IBD- and Behçet’s-like phenotype, resulting from an intronic, loss of function mutation (c.248-7G > A) in ELF4, an X-linked transcription factor executing multiple biological functions. The … Read more

IgA-dependent cell phagocytosis of HIV-infected cells elicits cross-presentation to CD8+T cells and immune memory in effector monocytes. Andrea Cottignies-Calamarte

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Mucosal Immunol. 2025 Sep 18:S1933-0219(25)00094-7. doi: 10.1016/j.mucimm.2025.09.004. Online ahead of print. ABSTRACT Mucosal IgA antibodies are the first defence against mucosal infections. Besides targeting specific antigens by their Fab-region, IgA also mediates antiviral functions via their Fc-domain, allowing infected cells destruction by antibody-dependent cellular phagocytosis (ADCP). Passive immunisation with anti-HIV-1 IgG protected Non-Human Primates in … Read more

Rhinovirus C15 infection induces airway epithelial cell remodeling and robust inflammatory responses: Potential implications for airway obstruction in children. Yiran Li

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Mucosal Immunol. 2025 Sep 18:S1933-0219(25)00092-3. doi: 10.1016/j.mucimm.2025.09.002. Online ahead of print. ABSTRACT Despite recognition of rhinovirus-C (RV-C) as a cause of severe respiratory exacerbations, little is known about the pathogenesis of RV-C infections. We infected mucociliary-differentiated primary tracheobronchial epithelial cells with RV-C15 or RV-A16. Initial RNASeq data showed that, compared to RV-A16, RV-C15 decreased expression … Read more

Akkermansia muciniphila ameliorates salmonella-induced colitis and intestinal fibrosis. Abdulhadi Suwandi

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Mucosal Immunol. 2025 Sep 15:S1933-0219(25)00095-9. doi: 10.1016/j.mucimm.2025.09.005. Online ahead of print. ABSTRACT Salmonella enterica serovar Typhimurium is a food-borne pathogen and a major cause of gastroenteritis in humans. The intestinal microbiota provides colonization resistance to enteric pathogens such as S. Typhimurium. Akkermansia muciniphila is an anaerobic bacterium commonly found in the intestinal tract of humans … Read more

Neutrophil ADAM10 promotes migration and inflammation in ARDS by modulating adhesion and chemokine signaling. Anika Fuhr

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Mucosal Immunol. 2025 Sep 12:S1933-0219(25)00093-5. doi: 10.1016/j.mucimm.2025.09.003. Online ahead of print. ABSTRACT Acute respiratory distress syndrome (ARDS) is characterized by excessive neutrophil recruitment, endothelial barrier dysfunction, and persistent inflammation. A Disintegrin and Metalloproteinase 10 (ADAM10) regulates leukocyte trafficking by cleaving adhesion molecules such as VE-cadherin and JAM-A, but its role in neutrophil-driven lung injury remains … Read more

Single cell map of the adult female mouse urethra reveals epithelial and stromal macrophages with distinct functional identities. None Jasmine

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Mucosal Immunol. 2025 Sep 2:S1933-0219(25)00091-1. doi: 10.1016/j.mucimm.2025.09.001. Online ahead of print. ABSTRACT Epithelial linings at mucosal sites act in concert with resident immune cells to direct host defense. The epithelial lining of the urethra is an understudied mucosal barrier with emerging roles in antimicrobial defense during urinary tract infections. Here, we present a comprehensive cellular … Read more

CREB-mediated sensing of bacterial membrane vesicles unveils a conserved host defense pathway. Saifei Wang

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Mucosal Immunol. 2025 Aug 27:S1933-0219(25)00090-X. doi: 10.1016/j.mucimm.2025.08.007. Online ahead of print. ABSTRACT Bacterial membrane vesicles (MVs) are critical mediators of virulence factor delivery and intercellular communication, yet the mechanisms by which hosts detect and respond to these vesicles remain poorly characterized. Through transcriptional profiling, we found that MVs derived from the non-lethal pathogenic Erwinia carotovora … Read more

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