Mucosal Immunology

RelB and C/EBPα critically regulate the development of Peyer’s patch mononuclear phagocytes. Takashi Kanaya

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Mucosal Immunol. 2024 Oct 14:S1933-0219(24)00108-9. doi: 10.1016/j.mucimm.2024.10.005. Online ahead of print. ABSTRACT To establish protection against harmful foreign antigens, the small intestine harbors guardian sites called Peyer’s patches (PPs). PPs take up antigens through microfold (M) cells and transfer them to the sub-epithelial dome (SED), which contains a high density of mononuclear phagocytes (MPs), for … Read more

TRIM29 controls enteric RNA virus-induced intestinal inflammation by targeting NLRP6 and NLRP9b signaling pathways. Junying Wang

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Mucosal Immunol. 2024 Oct 11:S1933-0219(24)00107-7. doi: 10.1016/j.mucimm.2024.10.004. Online ahead of print. ABSTRACT Infections by enteric virus and intestinal inflammation are recognized as a leading cause of deadly gastroenteritis, and NLRP6 and NLRP9b signaling control these infection and inflammation. However, the regulatory mechanisms of the NLRP6 and NLRP9b signaling in enteric viral infection remain unexplored. In … Read more

A reappraisal of IL-9 in inflammation and cancer. Fabian Bick

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Mucosal Immunol. 2024 Oct 8:S1933-0219(24)00106-5. doi: 10.1016/j.mucimm.2024.10.003. Online ahead of print. ABSTRACT While much is known about the functional effects of type 2 cytokines interleukin (IL)-4, IL-5 and IL-13 in homeostasis and disease, we still poorly understand the functions of IL-9. Chronic inflammation seen in allergic diseases, autoimmunity and cancer is however frequently accompanied by … Read more

Sensory neuroimmune interactions at the barrier. Zhen Wang

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Mucosal Immunol. 2024 Oct 5:S1933-0219(24)00104-1. doi: 10.1016/j.mucimm.2024.10.001. Online ahead of print. ABSTRACT Epithelial barriers such as the skin, lung, and gut, in addition to having unique physiologic functions, are designed to preserve tissue homeostasis upon challenge with a variety of allergens, irritants, or pathogens. Both the innate and adaptive immune systems play a critical role … Read more

CSF1-dependent macrophage support matrisome and epithelial stress-induced keratin remodeling in Eosinophilic esophagitis. Taylor M Benson

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Mucosal Immunol. 2024 Sep 27:S1933-0219(24)00099-0. doi: 10.1016/j.mucimm.2024.09.006. Online ahead of print. ABSTRACT Atopic diseases such as Eosinophilic Esophagitis (EoE) often progress into fibrosis (FS-EoE), compromising organ function with limited targeted treatment options. Mechanistic understanding of FS-EoE progression is confounded by the lack of preclinical models and the heavy focus of research on eosinophils themselves. We … Read more

Dietary fiber promotes antigen presentation on intestinal epithelial cells and development of small intestinal CD4+CD8αα+ intraepithelial T cells. Naomi Rodriguez-Marino

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Mucosal Immunol. 2024 Sep 5:S1933-0219(24)00092-8. doi: 10.1016/j.mucimm.2024.08.010. Online ahead of print. ABSTRACT The impact of dietary fiber on intestinal T cell development is poorly understood. Here we show that a low fiber diet reduces MHC-II antigen presentation by small intestinal epithelial cells (IECs) and consequently impairs development of CD4+CD8αα+ intraepithelial lymphocytes (DP IELs) through changes … Read more

Deciphering the therapeutic potential of Myeloid-Specific JAK2 inhibition in acute respiratory distress syndrome. Shupei Gao

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Mucosal Immunol. 2024 Aug 21:S1933-0219(24)00089-8. doi: 10.1016/j.mucimm.2024.08.008. Online ahead of print. ABSTRACT Acute respiratory distress syndrome (ARDS) is a life-threatening condition characterized by severe inflammation and pulmonary dysfunction. Despite advancements in critical care, effective pharmacological interventions for ARDS remain elusive. While Janus kinase 2 (JAK2) inhibitors have emerged as an innovative treatment for numerous autoinflammatory … Read more

CSF1R inhibition by PLX5622 reduces pulmonary fungal infection by depleting MHCIIhi interstitial lung macrophages. Sally H Mohamed

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Mucosal Immunol. 2024 Aug 20:S1933-0219(24)00088-6. doi: 10.1016/j.mucimm.2024.08.007. Online ahead of print. ABSTRACT PLX5622 is a small molecular inhibitor of the CSF1 receptor (CSF1R) and is widely used to deplete macrophages within the central nervous system (CNS). We investigated the impact of PLX5622 treatment in wild-type C57BL/6 mice and discovered that one-week treatment with PLX5622 was … Read more

Combined plasma protein and Tmem profiling discern IBD-patient-immunotypes related to intestinal disease and treatment outcomes: Short title: Defining immunotypes in CD and UC. Maud Heredia

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Mucosal Immunol. 2024 Sep 25:S1933-0219(24)00097-7. doi: 10.1016/j.mucimm.2024.09.004. Online ahead of print. ABSTRACT Inflammatory bowel disease (IBD) chronicity results from memory T helper cell (Tmem) reactivation. Identifying patient-specific immunotypes is crucial for tailored treatment. We conducted a comprehensive study integrating circulating immune proteins and circulating Tmem, with intestinal tissue histology and mRNA analysis, in therapy-naïve pediatric … Read more

Dissecting the metabolic signaling pathways by which microbial molecules drive the differentiation of regulatory B cells. Maik Luu

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Mucosal Immunol. 2024 Sep 16:S1933-0219(24)00096-5. doi: 10.1016/j.mucimm.2024.09.003. Online ahead of print. ABSTRACT The host-microbiome axis has been implicated in promoting anti-inflammatory immune responses. Yet, the underlying molecular mechanisms of commensal-mediated IL-10 production by regulatory B cells (Bregs) are not fully elucidated. Here, we demonstrate that bacterial CpG motifs trigger the signaling downstream of TLR9 promoting … Read more

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