Mucosal Immunology

Expansion of genital Tregs reduces neutrophil influx and maintains mucosal barrier integrity during inflammatory bacteria challenge. Faisal Nuhu

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Mucosal Immunol. 2025 Aug 21:S1933-0219(25)00089-3. doi: 10.1016/j.mucimm.2025.08.006. Online ahead of print. ABSTRACT Genital inflammation is associated with increased HIV risk. We previously found that endocervical Tregs correlated with decreased genital inflammation and reduced HIV target cells. IL-2 induces Tregs, and efforts to potentiate its regulatory activities clinically are ongoing. In this study, intraperitoneal administration of … Read more

Leukotriene B4 regulates T cell recognition and control of MCMV in mucosal tissues. Lauren E Springer

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Mucosal Immunol. 2025 Aug 18:S1933-0219(25)00085-6. doi: 10.1016/j.mucimm.2025.08.002. Online ahead of print. ABSTRACT Lipid mediators play important, yet poorly understood roles in regulating immune responses. Cytomegalovirus (CMV) is a herpesvirus that persists in mucosal tissues. Prior work suggests that leukotrienes, a class of inflammatory lipid mediators, contribute to viral control. Infection with murine (M)CMV altered leukotriene … Read more

Clostridioides difficile toxin A and toxin B inhibit toxin-specific adaptive immune responses through glucosyltransferase-dependent activity. Jeffrey R Maslanka

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Mucosal Immunol. 2025 Aug 16:S1933-0219(25)00087-X. doi: 10.1016/j.mucimm.2025.08.004. Online ahead of print. ABSTRACT Clostridioides difficile colonizes the gastrointestinal tract and secretes two virulence factors: toxin A (TcdA) and toxin B (TcdB). Protective immunity against C. difficile infection is limited as patients are susceptible to multiple rounds of recurrent infections. The factors determining whether immunity to TcdA … Read more

T-cell immunity against influenza virus does not require Th1 or Th17 master regulator transcription factors. Kunal Dhume

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Mucosal Immunol. 2025 Aug 15:S1933-0219(25)00088-1. doi: 10.1016/j.mucimm.2025.08.005. Online ahead of print. ABSTRACT Transcriptional programming needed for CD4 T cell immunity against influenza A virus (IAV) is unclear. Most antiviral CD4 T cells fit Th1 criteria, but cells unable to develop Th1 identity, through deletion of the transcription factors T-bet and Eomesodermin, remain protective. These double … Read more

C10ORF99 (GPR15L) increases susceptibility to colitis and colitis-induced colorectal cancer via GPR15-independent mechanisms, while mediating GPR15-dependent T cell migration to the large intestine. Gerald J O’Connor

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Mucosal Immunol. 2025 Aug 13:S1933-0219(25)00084-4. doi: 10.1016/j.mucimm.2025.08.001. Online ahead of print. ABSTRACT GPR15 is a homing receptor important for T cell migration to the large intestine, the primary site of inflammation in ulcerative colitis. Both GPR15 and its ligand, C10ORF99, represent potential therapeutic targets for the treatment of IBD; however, the roles of C10ORF99 in … Read more

Junctional epithelial Plakoglobin facilitates intestinal inflammation by p38MAPK-dependent activation of the inflammasome. Matthias Kelm

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Mucosal Immunol. 2025 Aug 13:S1933-0219(25)00086-8. doi: 10.1016/j.mucimm.2025.08.003. Online ahead of print. ABSTRACT Desmosomes play an underexplored role in intestinal homeostasis and are linked to the pathogenesis of inflammatory bowel diseases. We found a novel function of the desmosomal plaque protein Plakoglobin (JUP) in initiating the innate immune response to facilitate intestinal inflammation. Tissue samples from … Read more

Single cell transcriptional analysis of human adenoids identifies molecular features of airway microfold cells. Samuel Alvarez-Arguedas

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Mucosal Immunol. 2025 Jul 26:S1933-0219(25)00077-7. doi: 10.1016/j.mucimm.2025.07.006. Online ahead of print. ABSTRACT The nasal, oropharyngeal, and bronchial mucosa are primary contact points for airborne pathogens like Mycobacterium tuberculosis (Mtb), SARS-CoV-2, and influenza virus. While mucosal surfaces can function as both entry points and barriers to infection, mucosa-associated lymphoid tissues (MALT) facilitate early immune responses to … Read more

Dynamics of virus-specific CD8+ T cells in the human nasal cavity. Joey Ming Er Lim

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Mucosal Immunol. 2025 Jul 22:S1933-0219(25)00078-9. doi: 10.1016/j.mucimm.2025.07.007. Online ahead of print. ABSTRACT The nasal cavity is the entry site for respiratory viruses. Understanding how the nasal cavity sustains memory CD8+ T cell is essential for improving respiratory virus management and vaccine development. Here, we sampled CD8+ T cells from the upper nasal turbinate and peripheral … Read more

Microbial dysbiosis sculpts a systemic ILC3/IL-17 axis governing lung inflammatory responses. Ahmed Kabil

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Mucosal Immunol. 2025 Jul 20:S1933-0219(25)00073-X. doi: 10.1016/j.mucimm.2025.07.002. Online ahead of print. ABSTRACT Advancements in vaccination and sanitation have significantly reduced the prevalence and burden of infectious diseases; however, these benefits have coincided with a marked rise in autoimmune and allergic disorders. Recent studies have investigated these linked trends through the lens of host-microbiome alterations, proposing … Read more

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