Mucosal Immunology

Mucosal Immunol. 2025 Sep 24:S1933-0219(25)00097-2. doi: 10.1016/j.mucimm.2025.09.007. Online ahead of print. ABSTRACT Monogenic errors of immunity can present with inflammatory bowel disease (IBD)-like enteropathy. We describe an adolescent with IBD- and Behçet’s-like phenotype, resulting from an intronic, loss of function mutation (c.248-7G > A) in ELF4, an X-linked transcription factor executing multiple biological functions. The … Read more

Mucosal Immunol. 2025 Sep 18:S1933-0219(25)00094-7. doi: 10.1016/j.mucimm.2025.09.004. Online ahead of print. ABSTRACT Mucosal IgA antibodies are the first defence against mucosal infections. Besides targeting specific antigens by their Fab-region, IgA also mediates antiviral functions via their Fc-domain, allowing infected cells destruction by antibody-dependent cellular phagocytosis (ADCP). Passive immunisation with anti-HIV-1 IgG protected Non-Human Primates in … Read more

Mucosal Immunol. 2025 Sep 18:S1933-0219(25)00092-3. doi: 10.1016/j.mucimm.2025.09.002. Online ahead of print. ABSTRACT Despite recognition of rhinovirus-C (RV-C) as a cause of severe respiratory exacerbations, little is known about the pathogenesis of RV-C infections. We infected mucociliary-differentiated primary tracheobronchial epithelial cells with RV-C15 or RV-A16. Initial RNASeq data showed that, compared to RV-A16, RV-C15 decreased expression … Read more

Mucosal Immunol. 2025 Sep 15:S1933-0219(25)00095-9. doi: 10.1016/j.mucimm.2025.09.005. Online ahead of print. ABSTRACT Salmonella enterica serovar Typhimurium is a food-borne pathogen and a major cause of gastroenteritis in humans. The intestinal microbiota provides colonization resistance to enteric pathogens such as S. Typhimurium. Akkermansia muciniphila is an anaerobic bacterium commonly found in the intestinal tract of humans … Read more

Mucosal Immunol. 2025 Sep 12:S1933-0219(25)00093-5. doi: 10.1016/j.mucimm.2025.09.003. Online ahead of print. ABSTRACT Acute respiratory distress syndrome (ARDS) is characterized by excessive neutrophil recruitment, endothelial barrier dysfunction, and persistent inflammation. A Disintegrin and Metalloproteinase 10 (ADAM10) regulates leukocyte trafficking by cleaving adhesion molecules such as VE-cadherin and JAM-A, but its role in neutrophil-driven lung injury remains … Read more

Mucosal Immunol. 2025 Sep 2:S1933-0219(25)00091-1. doi: 10.1016/j.mucimm.2025.09.001. Online ahead of print. ABSTRACT Epithelial linings at mucosal sites act in concert with resident immune cells to direct host defense. The epithelial lining of the urethra is an understudied mucosal barrier with emerging roles in antimicrobial defense during urinary tract infections. Here, we present a comprehensive cellular … Read more

Mucosal Immunol. 2025 Aug 27:S1933-0219(25)00090-X. doi: 10.1016/j.mucimm.2025.08.007. Online ahead of print. ABSTRACT Bacterial membrane vesicles (MVs) are critical mediators of virulence factor delivery and intercellular communication, yet the mechanisms by which hosts detect and respond to these vesicles remain poorly characterized. Through transcriptional profiling, we found that MVs derived from the non-lethal pathogenic Erwinia carotovora … Read more

Mucosal Immunol. 2025 Aug 21:S1933-0219(25)00089-3. doi: 10.1016/j.mucimm.2025.08.006. Online ahead of print. ABSTRACT Genital inflammation is associated with increased HIV risk. We previously found that endocervical Tregs correlated with decreased genital inflammation and reduced HIV target cells. IL-2 induces Tregs, and efforts to potentiate its regulatory activities clinically are ongoing. In this study, intraperitoneal administration of … Read more

Mucosal Immunol. 2025 Aug 18:S1933-0219(25)00085-6. doi: 10.1016/j.mucimm.2025.08.002. Online ahead of print. ABSTRACT Lipid mediators play important, yet poorly understood roles in regulating immune responses. Cytomegalovirus (CMV) is a herpesvirus that persists in mucosal tissues. Prior work suggests that leukotrienes, a class of inflammatory lipid mediators, contribute to viral control. Infection with murine (M)CMV altered leukotriene … Read more

Mucosal Immunol. 2025 Aug 16:S1933-0219(25)00087-X. doi: 10.1016/j.mucimm.2025.08.004. Online ahead of print. ABSTRACT Clostridioides difficile colonizes the gastrointestinal tract and secretes two virulence factors: toxin A (TcdA) and toxin B (TcdB). Protective immunity against C. difficile infection is limited as patients are susceptible to multiple rounds of recurrent infections. The factors determining whether immunity to TcdA … Read more