Mucosal Immunology

M2 macrophage-derived Apolipoprotein E promotes fibroblast MMPs expression via LRP1-ERK signaling in chronic rhinosinusitis with nasal polyps. Ying Zhu

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Mucosal Immunol. 2025 Jul 19:S1933-0219(25)00075-3. doi: 10.1016/j.mucimm.2025.07.004. Online ahead of print. ABSTRACT Apolipoprotein E (APOE) expressed by macrophages modulates allergic inflammation and remodeling of the lower airway. However, its expression and functions in chronic rhinosinusitis with nasal polyps (CRSwNP) remain unclear. We sought to investigate the involvement of macrophage derived APOE in the pathogenesis of … Read more

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling. Sara Alonso

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Mucosal Immunol. 2025 Jul 17:S1933-0219(25)00076-5. doi: 10.1016/j.mucimm.2025.07.005. Online ahead of print. ABSTRACT Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mice harboring a microbiota-specific hyperproliferative γδ IEL (γδHYP) phenotype also upregulate the expression of the ectonucleotidase CD39, a marker of regulatory γδ T … Read more

TRIM33 prevents the exacerbation of allergic asthma by restricting the overactivation of alveolar macrophages. Jiaoyan Lv

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Mucosal Immunol. 2025 Jul 16:S1933-0219(25)00074-1. doi: 10.1016/j.mucimm.2025.07.003. Online ahead of print. ABSTRACT Alveolar macrophages (AMs) and dendritic cells (DCs) are the two major types of primary innate immune cells in allergic asthma and their functions were elaborately regulated during the progression of asthma. Tripartite motif-containing protein 33 (TRIM33) is a multifunctional protein that regulates differentiation … Read more

Type-I interferons in Vulvovaginal Candidiasis: Mechanism of epithelial early defense and immune regulation against Candida albicans. Emilse Rodriguez

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Mucosal Immunol. 2025 Jul 10:S1933-0219(25)00072-8. doi: 10.1016/j.mucimm.2025.07.001. Online ahead of print. ABSTRACT Vulvovaginal candidiasis (VVC) is a mucosal infection predominantly caused by Candida albicans, affecting over three-quarters of immunocompetent women worldwide. While the female genital tract mucosa is the primary defense against the fungus, the specific immune mechanisms involved in this host-pathogen interaction remain largely … Read more

Tofacitinib ameliorates Campylobacter-induced intestinal pathology by suppressing IFNγ producing ILCs and T cells. Anna A Korchagina

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Mucosal Immunol. 2025 Jul 2:S1933-0219(25)00070-4. doi: 10.1016/j.mucimm.2025.06.010. Online ahead of print. ABSTRACT Patients with autoimmune diseases are more susceptible to foodborne infections, which can be exacerbated by immunosuppressive therapy. Tofacitinib, a JAK/STAT pathway inhibitor, was recently approved for the treatment of ulcerative colitis, yet its effects on the pathogenesis of intestinal infections remain unclear. Here, … Read more

Fibroblast-derived CSF1 maintains colonization of gut mucosal macrophage to resist bacterial infection. Daichi Nonaka

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Mucosal Immunol. 2025 Jul 1:S1933-0219(25)00071-6. doi: 10.1016/j.mucimm.2025.06.011. Online ahead of print. ABSTRACT Macrophages play essential roles in immune defense and tissue homeostasis, but the mechanisms underlying their colonization in the gut mucosa remain incompletely understood. Here, we identify CSF1, primarily derived from fibroblasts, as the dominant factor maintaining mucosal macrophage colonization, whereas IL-34 deficiency alone … Read more

Single-cell RNA profiling identifies immune cell population shifts in diabetes associated mucosal inflammation. Bushra Alghamdi

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Mucosal Immunol. 2025 Jun 27:S1933-0219(25)00068-6. doi: 10.1016/j.mucimm.2025.06.008. Online ahead of print. ABSTRACT Poorly controlled diabetes significantly transforms periodontal disease from manageable to advanced, affecting millions worldwide, yet the mechanisms driving this destructive synergy remain unclear. To investigate these pathological interactions, we generated single-cell RNA sequencing profiles of diabetic periodontal tissue, revealing γδ T-cells as previously … Read more

Exogenous ephrin-A3 reverses loss of vaginal epithelial barrier protection in progestin-treated mice. Mohan Liu

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Mucosal Immunol. 2025 Jun 24:S1933-0219(25)00067-4. doi: 10.1016/j.mucimm.2025.06.007. Online ahead of print. ABSTRACT Desmosomes are junctional complexes that confer mechanical strength and enhance barrier protection at mucosal epithelial surfaces by anchoring intermediate filaments to plasma membrane. These roles are best defined in cutaneous epithelium, but we previously identified lower levels of the desmosomal cadherins desmoglein-1 (DSG1) … Read more

Placental inflammation-driven T cell memory formation promotes allergic responses in offspring via endogenous glucocorticoids. Myoung Seung Kwon

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Mucosal Immunol. 2025 Jun 13:S1933-0219(25)00066-2. doi: 10.1016/j.mucimm.2025.06.006. Online ahead of print. ABSTRACT Maternal exposure to environmental change during pregnancy is a critical determinant of offspring health and disease. Previous epidemiological studies have reported that maternal inflammation is linked to an increased incidence of postnatal allergy in offspring, although the underlying mechanisms remain largely unexplored. In … Read more

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