Mucosal Immunol. 2024 Nov 24:S1933-0219(24)00117-X. doi: 10.1016/j.mucimm.2024.11.009. Online ahead of print. ABSTRACT Host-directed therapy, using nasal administration of the Toll-like receptor 5 agonist flagellin in combination with antibiotics, has proven effective against pneumococcal pneumonia. In this study, we investigated the immune mechanisms underlying the therapy-induced protective effects. Transcriptomic analysis of lung tissue during infection revealed … Read more

Mucosal Immunol. 2024 Nov 23:S1933-0219(24)00116-8. doi: 10.1016/j.mucimm.2024.11.008. Online ahead of print. ABSTRACT CD4+ memory T cell (TM) reactivation drives chronicity in inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis. Defects driving loss of TM regulation likely differ between patients but remain undefined. In health, approximately 40 % of circulating gut-homing CD38+TM, express … Read more

Mucosal Immunol. 2024 Nov 22:S1933-0219(24)00113-2. doi: 10.1016/j.mucimm.2024.11.006. Online ahead of print. ABSTRACT IgA antibodies have an important role in clearing mucosal pathogens. In this study, we have examined the contribution of IgA to the immune control of the gastrointestinal bacterial pathogens Helicobacter pylori and Citrobacter rodentium. Both bacteria trigger a strong local IgA response that … Read more

Mucosal Immunol. 2024 Nov 22:S1933-0219(24)00111-9. doi: 10.1016/j.mucimm.2024.11.003. Online ahead of print. ABSTRACT The recurrent herpes simplex virus-1 (HSV-1) infection of the cornea can cause the development of herpes stromal keratitis (HSK). This chronic immunoinflammatory condition is a major cause of infection-induced vision loss. The previous episodes of HSK increase the risk of future recurrences in … Read more

Mucosal Immunol. 2024 Nov 22:S1933-0219(24)00114-4. doi: 10.1016/j.mucimm.2024.11.005. Online ahead of print. ABSTRACT Strongyloides ratti is a helminth parasite that displays tissue-migrating and intestinal life stages. Myeloid C-type lectin receptors (CLRs) are pattern recognition receptors that recognize pathogen-derived ligands and initiate immune responses. To date, the role of CLRs in S. ratti infection has not been … Read more

Mucosal Immunol. 2024 Nov 21:S1933-0219(24)00112-0. doi: 10.1016/j.mucimm.2024.11.004. Online ahead of print. ABSTRACT The fungal community of the skin microbiome is dominated by a single genus, Malassezia. Besides its symbiotic lifestyle at the host interface, this commensal yeast has also been associated with diverse inflammatory skin diseases in humans and pet animals. Stable colonization is maintained … Read more

Mucosal Immunol. 2024 Nov 8:S1933-0219(24)00110-7. doi: 10.1016/j.mucimm.2024.11.002. Online ahead of print. ABSTRACT There is an unmet need for effectively treating dry eye disease (DED), a T cell-mediated chronic, inflammatory ocular surface disorder. Given the potential of nonneuronal adrenergic system in modulating T cell response, we herein investigated the therapeutic efficacy and the underlying mechanisms of … Read more

Mucosal Immunol. 2024 Nov 7:S1933-0219(24)00109-0. doi: 10.1016/j.mucimm.2024.11.001. Online ahead of print. ABSTRACT Altered intestinal immune homeostasis leads to chronic inflammation in Crohn’s disease (CD). To address disease- and tissue-specific alterations, we performed a T cell-centric mass cytometry analysis of peripheral and intestinal lymphocytes from patients with CD and healthy donors’ PBMCs. Chronic intestinal inflammation enforced … Read more

Mucosal Immunol. 2023 Oct 27:S1933-0219(23)00081-8. doi: 10.1016/j.mucimm.2023.10.003. Online ahead of print. NO ABSTRACT PMID:39491094 | DOI:10.1016/j.mucimm.2023.10.003

Mucosal Immunol. 2023 Oct 27:S1933-0219(23)00082-X. doi: 10.1016/j.mucimm.2023.10.004. Online ahead of print. ABSTRACT Endogenous retroelements play vital roles in sustaining immune homeostasis. Activation of endogenous retroelements can trigger cGAS/STING pathway and downstream pro-inflammatory cytokine production. M1 macrophages, which can be induced by pro-inflammatory cytokines, are involved in the development of colitis. Here we aimed to determine … Read more