Mucosal Immunology

Memory T cell formation and phenotype varies across intestinal compartments. Sarah Sandford

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Mucosal Immunol. 2025 Jun 12:S1933-0219(25)00065-0. doi: 10.1016/j.mucimm.2025.06.005. Online ahead of print. ABSTRACT Numerous studies have shown that tissue-resident memory T (TRM) cells form in the intestine following pathogen clearance. However, most knowledge of intestinal TRM cells has derived from analyses restricted to the small intestine (SI). In contrast, less is known about TRM cell formation … Read more

Innate immunity of the gut epithelium: Blowing in the WNT?. Maaike H de Vries

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Mucosal Immunol. 2025 Jun 10:S1933-0219(25)00064-9. doi: 10.1016/j.mucimm.2025.06.004. Online ahead of print. ABSTRACT Intestinal epithelial cells need to be able to launch a quick and adequate immune response against pathogens, while tolerating commensals. This delicate balance requires a tight control over the activation of the NFκB and Interferon pathways to prevent chronic inflammation. Simultaneously, intestinal stem … Read more

Dysbiosis of the gut microbiome may contribute to the pathogenesis of oral lichen planus through Treg dysregulation. Shiho Yokomizo

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Mucosal Immunol. 2025 Jun 9:S1933-0219(25)00055-8. doi: 10.1016/j.mucimm.2025.05.009. Online ahead of print. ABSTRACT Oral lichen planus (OLP) is a chronic inflammatory disorder with autoimmune features and malignant transformation risk, lacking a definitive treatment, with CD4+ T cells being pivotal in its pathogenesis. Dysbiosis, an imbalance in the microbiome, is linked to various autoimmune and inflammatory diseases, … Read more

Repeated enema administration in rhesus macaques is not sufficient to promote bacterial dysbiosis or gastrointestinal dysfunction. Alexandra M Ortiz

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Mucosal Immunol. 2025 Jun 7:S1933-0219(25)00058-3. doi: 10.1016/j.mucimm.2025.06.002. Online ahead of print. ABSTRACT Chronic gastrointestinal diseases are a significant global health burden that can require the use of gastrointestinal-cleansing regimens for diagnostics or therapeutic treatment. These regimens are beneficial for facilitating surgical preparation, drug delivery, colorectal cancer screenings, and personal use is common among proponents of … Read more

Editing B cells at the IGHA2 gene position provides alternative route to therapeutic IgA production. Marine Cahen

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Mucosal Immunol. 2025 Jun 5:S1933-0219(25)00057-1. doi: 10.1016/j.mucimm.2025.06.001. Online ahead of print. ABSTRACT As professional and long-lived immunoglobulin (Ig) producers, B cells represent attractive candidates for adoptive immunotherapy and their highly expressed Ig heavy (IgH) chain locus is ideal for editing. Each of its constant genes, expressed after class switch recombination (CSR), affords an attractive platform … Read more

Inflammatory monocyte-derived amphiregulin mediates intestinal fibrosis in Crohn’s disease by activating PI3K/AKT. Shu Wang

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Mucosal Immunol. 2025 Jun 4:S1933-0219(25)00056-X. doi: 10.1016/j.mucimm.2025.05.008. Online ahead of print. ABSTRACT Intestinal fibrosis is one of the most threatening complications of Crohn’s disease (CD). Although our previous study identified the profibrotic role of amphiregulin (AREG) in intestinal fibrosis, the underlying molecular mechanisms remain poorly understood. This study aimed to elucidate the mechanisms by which … Read more

Distal airway epithelial progenitors mediate TGF-β release to drive lung CD8+ TRM induction following mucosal BCG vaccination. Judith A Blake

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Mucosal Immunol. 2025 May 30:S1933-0219(25)00054-6. doi: 10.1016/j.mucimm.2025.05.007. Online ahead of print. ABSTRACT A principal reason for the high global morbidity and mortality of tuberculosis (TB) is the lack of efficacy of the only licensed TB vaccine, Bacillus Calmette-Guérin (BCG), as intradermal BCG does not induce local pulmonary immune memory. Animal studies have shown that inhalation … Read more

MAIT cells exacerbate colonic inflammation in a genetically diverse murine model of spontaneous colitis. Liyen Loh

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Mucosal Immunol. 2025 May 25:S1933-0219(25)00053-4. doi: 10.1016/j.mucimm.2025.05.006. Online ahead of print. ABSTRACT IL-17-producing lymphocytes are involved in both tissue repair and the propagation of inflammation, with their effects highly context-dependent. Mucosal-Associated-Invariant-T-cells (MAIT), a subset of innate-like T cells with features of both Th1 and Th17 lineages, are increasingly recognized for their roles in mucosal immunity. … Read more

Inflammatory chemokine receptors CCR1, CCR2, CCR3 and CCR5 are essential for an optimal T cell response to influenza. Marieke Pingen

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Mucosal Immunol. 2025 May 23:S1933-0219(25)00052-2. doi: 10.1016/j.mucimm.2025.05.005. Online ahead of print. ABSTRACT Inflammatory chemokine receptors CCR1/2/3/5 (iCCRs) play an important role in the recruitment of immune cells involved in innate immune functions and orchestrating the adaptive immune response. Here we utilise an influenza A virus (IAV) challenge to investigate the combinatorial roles of the iCCRs … Read more

Inducible, but not constitutive, pancreatic REG/Reg isoforms are regulated by intestinal microbiota and pancreatic diseases. Yixuan Zhou

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Mucosal Immunol. 2025 May 19:S1933-0219(25)00050-9. doi: 10.1016/j.mucimm.2025.05.003. Online ahead of print. ABSTRACT The REG/Reg gene locus encodes a conserved family of potent antimicrobial but also pancreatitis-associated proteins. Here we investigated whether REG/Reg family members differ in their baseline expression levels and abilities to be regulated in the pancreas and gut upon perturbations. We found, in … Read more

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