Mucosal Immunology

Type-I interferons in Vulvovaginal Candidiasis: Mechanism of epithelial early defense and immune regulation against Candida albicans. Emilse Rodriguez

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Mucosal Immunol. 2025 Jul 10:S1933-0219(25)00072-8. doi: 10.1016/j.mucimm.2025.07.001. Online ahead of print. ABSTRACT Vulvovaginal candidiasis (VVC) is a mucosal infection predominantly caused by Candida albicans, affecting over three-quarters of immunocompetent women worldwide. While the female genital tract mucosa is the primary defense against the fungus, the specific immune mechanisms involved in this host-pathogen interaction remain largely … Read more

Tofacitinib ameliorates Campylobacter-induced intestinal pathology by suppressing IFNγ producing ILCs and T cells. Anna A Korchagina

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Mucosal Immunol. 2025 Jul 2:S1933-0219(25)00070-4. doi: 10.1016/j.mucimm.2025.06.010. Online ahead of print. ABSTRACT Patients with autoimmune diseases are more susceptible to foodborne infections, which can be exacerbated by immunosuppressive therapy. Tofacitinib, a JAK/STAT pathway inhibitor, was recently approved for the treatment of ulcerative colitis, yet its effects on the pathogenesis of intestinal infections remain unclear. Here, … Read more

Fibroblast-derived CSF1 maintains colonization of gut mucosal macrophage to resist bacterial infection. Daichi Nonaka

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Mucosal Immunol. 2025 Jul 1:S1933-0219(25)00071-6. doi: 10.1016/j.mucimm.2025.06.011. Online ahead of print. ABSTRACT Macrophages play essential roles in immune defense and tissue homeostasis, but the mechanisms underlying their colonization in the gut mucosa remain incompletely understood. Here, we identify CSF1, primarily derived from fibroblasts, as the dominant factor maintaining mucosal macrophage colonization, whereas IL-34 deficiency alone … Read more

Single-cell RNA profiling identifies immune cell population shifts in diabetes associated mucosal inflammation. Bushra Alghamdi

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Mucosal Immunol. 2025 Jun 27:S1933-0219(25)00068-6. doi: 10.1016/j.mucimm.2025.06.008. Online ahead of print. ABSTRACT Poorly controlled diabetes significantly transforms periodontal disease from manageable to advanced, affecting millions worldwide, yet the mechanisms driving this destructive synergy remain unclear. To investigate these pathological interactions, we generated single-cell RNA sequencing profiles of diabetic periodontal tissue, revealing γδ T-cells as previously … Read more

Exogenous ephrin-A3 reverses loss of vaginal epithelial barrier protection in progestin-treated mice. Mohan Liu

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Mucosal Immunol. 2025 Jun 24:S1933-0219(25)00067-4. doi: 10.1016/j.mucimm.2025.06.007. Online ahead of print. ABSTRACT Desmosomes are junctional complexes that confer mechanical strength and enhance barrier protection at mucosal epithelial surfaces by anchoring intermediate filaments to plasma membrane. These roles are best defined in cutaneous epithelium, but we previously identified lower levels of the desmosomal cadherins desmoglein-1 (DSG1) … Read more

Placental inflammation-driven T cell memory formation promotes allergic responses in offspring via endogenous glucocorticoids. Myoung Seung Kwon

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Mucosal Immunol. 2025 Jun 13:S1933-0219(25)00066-2. doi: 10.1016/j.mucimm.2025.06.006. Online ahead of print. ABSTRACT Maternal exposure to environmental change during pregnancy is a critical determinant of offspring health and disease. Previous epidemiological studies have reported that maternal inflammation is linked to an increased incidence of postnatal allergy in offspring, although the underlying mechanisms remain largely unexplored. In … Read more

Memory T cell formation and phenotype varies across intestinal compartments. Sarah Sandford

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Mucosal Immunol. 2025 Jun 12:S1933-0219(25)00065-0. doi: 10.1016/j.mucimm.2025.06.005. Online ahead of print. ABSTRACT Numerous studies have shown that tissue-resident memory T (TRM) cells form in the intestine following pathogen clearance. However, most knowledge of intestinal TRM cells has derived from analyses restricted to the small intestine (SI). In contrast, less is known about TRM cell formation … Read more

Innate immunity of the gut epithelium: Blowing in the WNT?. Maaike H de Vries

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Mucosal Immunol. 2025 Jun 10:S1933-0219(25)00064-9. doi: 10.1016/j.mucimm.2025.06.004. Online ahead of print. ABSTRACT Intestinal epithelial cells need to be able to launch a quick and adequate immune response against pathogens, while tolerating commensals. This delicate balance requires a tight control over the activation of the NFκB and Interferon pathways to prevent chronic inflammation. Simultaneously, intestinal stem … Read more

Dysbiosis of the gut microbiome may contribute to the pathogenesis of oral lichen planus through Treg dysregulation. Shiho Yokomizo

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Mucosal Immunol. 2025 Jun 9:S1933-0219(25)00055-8. doi: 10.1016/j.mucimm.2025.05.009. Online ahead of print. ABSTRACT Oral lichen planus (OLP) is a chronic inflammatory disorder with autoimmune features and malignant transformation risk, lacking a definitive treatment, with CD4+ T cells being pivotal in its pathogenesis. Dysbiosis, an imbalance in the microbiome, is linked to various autoimmune and inflammatory diseases, … Read more

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