Mucosal Immunology

Mucosal Immunol. 2025 May 16:S1933-0219(25)00051-0. doi: 10.1016/j.mucimm.2025.05.004. Online ahead of print. ABSTRACT Helminth infections affect billions of people worldwide and cause substantial morbidity. Intestinal helminth infection provokes Type 2 inflammation orchestrated by CD4+ T helper type 2 (Th2) cells. Th2 cells cooperate with group 2 innate lymphoid cells (ILC2s) to produce interleukin (IL)-4 and IL-13 … Read more

Mucosal Immunol. 2025 May 14:S1933-0219(25)00049-2. doi: 10.1016/j.mucimm.2025.05.002. Online ahead of print. ABSTRACT The parasite Cryptosporidium is a leading cause of diarrhea and death in malnourished children and immunocompromised individuals and an important enteric pathogen of livestock. A mucosal vaccine to mitigate clinical disease and decrease transmission would address the public health impact of this organism, … Read more

Mucosal Immunol. 2025 May 10:S1933-0219(25)00048-0. doi: 10.1016/j.mucimm.2025.05.001. Online ahead of print. ABSTRACT Staphylococcus aureus is a significant cause of pulmonary infections, but existing mouse models fail to recapitulate human-specific responses. In this study, we developed a novel mouse model of S. aureus infection using humanized mice implanted with autologous fetal lung tissue. We show that … Read more

Mucosal Immunol. 2025 May 3:S1933-0219(25)00047-9. doi: 10.1016/j.mucimm.2025.04.009. Online ahead of print. ABSTRACT Dyslipidemia, characterized by altered lipid profiles, influences host immune responses against infections, including Mycobacterium tuberculosis (Mtb). While the effects of dyslipidemia on conventional T cell responses are well documented, its impact on group 1-CD1 restricted T cells, a distinct subset of lipid antigen-specific … Read more

Mucosal Immunol. 2025 May 2:S1933-0219(25)00046-7. doi: 10.1016/j.mucimm.2025.04.008. Online ahead of print. ABSTRACT Influenza A virus (IAV) infections trigger asthma attacks and cause airway hyperresponsiveness (AHR) in murine models. However, the mechanism by which AHR is induced remains to be fully elucidated. Here, we show that targeting the interleukin (IL)-33 suppression of tumorigenicity 2 (ST2) receptor … Read more

Mucosal Immunol. 2025 Apr 25:S1933-0219(25)00043-1. doi: 10.1016/j.mucimm.2025.04.005. Online ahead of print. ABSTRACT Pregnancies rely upon the balance between fetal and maternal immune systems. Employing imaging mass cytometry, this study creates a spatial map landscape to unravel the cellular dynamics within the placental villi (PV). Consistent with previous data we report structural remodeling in PV, highlighted … Read more

Mucosal Immunol. 2025 Apr 23:S1933-0219(25)00045-5. doi: 10.1016/j.mucimm.2025.04.007. Online ahead of print. ABSTRACT Severe respiratory syncytial virus (RSV) infection during infancy is associated with a 2 to 4-fold increased risk for the development of wheezing and asthma. Recent studies have implicated microbiome changes, either within the lung or gut, during early life can also affect the … Read more

Mucosal Immunol. 2025 Apr 19:S1933-0219(25)00044-3. doi: 10.1016/j.mucimm.2025.04.006. Online ahead of print. ABSTRACT Protein arginine deiminase 4 (PAD4) has emerged as a potential therapeutic target for various diseases due to its role in promoting neutrophil extracellular trap (NET) formation. NETs, composed of DNA and antimicrobial proteins, serve as a defense mechanism against pathogens but can also … Read more

Mucosal Immunol. 2025 Apr 17:S1933-0219(25)00042-X. doi: 10.1016/j.mucimm.2025.04.004. Online ahead of print. ABSTRACT Promoting intestinal regeneration and enhancing mucosal healing have emerged as promising therapeutic alternatives for treating intestinal disorders that compromise epithelial barrier integrity and function. However, the cellular and molecular mechanisms underlying these processes remain poorly understood. This knowledge gap is partly due to … Read more

Mucosal Immunol. 2025 Apr 13:S1933-0219(25)00041-8. doi: 10.1016/j.mucimm.2025.04.003. Online ahead of print. ABSTRACT The colonic mucus layer acts as a physicochemical barrier to pathogen invasion and as a habitat for mucus-associated microbes. This mucosal microbiome plays a crucial role in moderating mucus production, maintaining barrier integrity, and shaping the host immune response. However, unchecked mucin foraging … Read more